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An introduction to LifeLines DEEP: study design and baseline characteristics

Ettje F. Tigchelaar, Alexandra Zhernakova, Jackie A.M. Dekens, Gerben Hermes, Agnieszka Baranska, Zlatan Mujagic, Morris A. Swertz, Angélica M. Muñoz, Patrick Deelen, Maria C. Cénit, Lude Franke, Salome Scholtens, Ronald P. Stolk, Cisca Wijmenga, Edith J.M. Feskens
doi: https://doi.org/10.1101/009217
Ettje F. Tigchelaar
1University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands
2Top Institute Food and Nutrition, Wageningen, the Netherlands
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Alexandra Zhernakova
1University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands
2Top Institute Food and Nutrition, Wageningen, the Netherlands
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Jackie A.M. Dekens
1University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands
2Top Institute Food and Nutrition, Wageningen, the Netherlands
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Gerben Hermes
2Top Institute Food and Nutrition, Wageningen, the Netherlands
3Laboratory of Microbiology, Wageningen University, Wageningen, the Netherlands
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Agnieszka Baranska
2Top Institute Food and Nutrition, Wageningen, the Netherlands
4Department of Toxicology, Nutrition and Toxicology Research (NUTRIM), Maastricht University Medical Center+, Maastricht, the Netherlands
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Zlatan Mujagic
2Top Institute Food and Nutrition, Wageningen, the Netherlands
5Division of Gastroenterology-Hepatology, Maastricht University Medical Center+, Maastricht, the Netherlands
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Morris A. Swertz
1University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands
2Top Institute Food and Nutrition, Wageningen, the Netherlands
6University of Groningen, University Medical Center Groningen, Genomics Coordination Center, Groningen, the Netherlands
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Angélica M. Muñoz
1University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands
7University of Antioquia, Research Group in Food and Human Nutrition, Medellín, Colombia
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Patrick Deelen
1University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands
6University of Groningen, University Medical Center Groningen, Genomics Coordination Center, Groningen, the Netherlands
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Maria C. Cénit
1University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands
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Lude Franke
1University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands
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Salome Scholtens
8LifeLines Cohort Study, Groningen, the Netherlands
9University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, the Netherlands
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Ronald P. Stolk
8LifeLines Cohort Study, Groningen, the Netherlands
9University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, the Netherlands
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Cisca Wijmenga
1University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands
2Top Institute Food and Nutrition, Wageningen, the Netherlands
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Edith J.M. Feskens
2Top Institute Food and Nutrition, Wageningen, the Netherlands
10Division of Human Nutrition, Section Nutrition and Epidemiology, Wageningen University, Wageningen, the Netherlands
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ABSTRACT

There is a critical need for population-based prospective cohort studies because they follow individuals before the onset of disease, allowing for studies that can identify biomarkers and disease-modifying effects and thereby contributing to systems epidemiology. This paper describes the design and baseline characteristics of an intensively examined subpopulation of the LifeLines cohort in the Netherlands. For this unique sub-cohort, LifeLines DEEP, additional blood (n=1387), exhaled air (n=1425), fecal samples (n=1248) and gastrointestinal health questionnaires (n=1176) were collected for analysis of the genome, epigenome, transcriptome, microbiome, metabolome and other biological levels. Here, we provide an overview of the different data layers in LifeLines DEEP and present baseline characteristics of the study population including food intake and quality of life. We also describe how the LifeLines DEEP cohort allows for the detailed investigation of genetic, genomic and metabolic variation on a wealth of phenotypic outcomes. Finally, we examine the determinants of gastrointestinal health, an area of particular interest to us that can be addressed by LifeLines DEEP.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted September 16, 2014.
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An introduction to LifeLines DEEP: study design and baseline characteristics
Ettje F. Tigchelaar, Alexandra Zhernakova, Jackie A.M. Dekens, Gerben Hermes, Agnieszka Baranska, Zlatan Mujagic, Morris A. Swertz, Angélica M. Muñoz, Patrick Deelen, Maria C. Cénit, Lude Franke, Salome Scholtens, Ronald P. Stolk, Cisca Wijmenga, Edith J.M. Feskens
bioRxiv 009217; doi: https://doi.org/10.1101/009217
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An introduction to LifeLines DEEP: study design and baseline characteristics
Ettje F. Tigchelaar, Alexandra Zhernakova, Jackie A.M. Dekens, Gerben Hermes, Agnieszka Baranska, Zlatan Mujagic, Morris A. Swertz, Angélica M. Muñoz, Patrick Deelen, Maria C. Cénit, Lude Franke, Salome Scholtens, Ronald P. Stolk, Cisca Wijmenga, Edith J.M. Feskens
bioRxiv 009217; doi: https://doi.org/10.1101/009217

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