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Human Cytomegalovirus Intrahost Evolution–A New Avenue for Understanding and Controlling Herpesvirus Infections

Nicholas Renzette, Laura Gibson, Jeffrey D. Jensen, Timothy F. Kowalik
doi: https://doi.org/10.1101/009571
Nicholas Renzette
1Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester MA 01655, USA
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Laura Gibson
2Departments of Pediatrics and Medicine, Divisions of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester MA 01655, USA
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Jeffrey D. Jensen
3Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester MA 01655, USA
4School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne 1015, Switzerland
5Swiss Institute of Bioinformatics (SIB), Lausanne 1015, Switzerland
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Timothy F. Kowalik
1Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester MA 01655, USA
6Immunology and Microbiology Program, University of Massachusetts Medical School, Worcester MA 01655, USA
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  • For correspondence: timothy.kowalik@umassmed.edu
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Abstract

Human cytomegalovirus (HCMV) is exquisitely adapted to the human host, and much research has focused on its evolution over long timescales spanning millennia. Here, we review recent data exploring the evolution of the virus on much shorter timescales, on the order of days or months. We describe the intrahost genetic diversity of the virus isolated from humans, and how this diversity contributes to HCMV spatiotemporal evolution. We propose mechanisms to explain the high levels of intrahost diversity and discuss how this new information may shed light on HCMV infection and pathogenesis.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted September 30, 2014.
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Human Cytomegalovirus Intrahost Evolution–A New Avenue for Understanding and Controlling Herpesvirus Infections
Nicholas Renzette, Laura Gibson, Jeffrey D. Jensen, Timothy F. Kowalik
bioRxiv 009571; doi: https://doi.org/10.1101/009571
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Human Cytomegalovirus Intrahost Evolution–A New Avenue for Understanding and Controlling Herpesvirus Infections
Nicholas Renzette, Laura Gibson, Jeffrey D. Jensen, Timothy F. Kowalik
bioRxiv 009571; doi: https://doi.org/10.1101/009571

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