Imperfect drug penetration leads to spatial monotherapy and rapid evolution of multi-drug resistance

Stefany Moreno-Gamez; Alison L. Hill; Daniel I. S. Rosenbloom; Dmitri A. Petrov; Martin A. Nowak; Pleuni Pennings

doi:10.1101/013003

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Imperfect drug penetration leads to spatial monotherapy and rapid evolution of multi-drug resistance

Stefany Moreno-Gamez, Alison L. Hill, Daniel I. S. Rosenbloom, Dmitri A. Petrov, Martin A. Nowak, Pleuni Pennings

doi: https://doi.org/10.1101/013003

Stefany Moreno-Gamez

1Program for Evolutionary Dynamics, Department of Mathematics, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA

2Centre for Ecological and Evolutionary Studies, University of Groningen, Groningen, 9747 AG, Netherlands

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Alison L. Hill

1Program for Evolutionary Dynamics, Department of Mathematics, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA

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Daniel I. S. Rosenbloom

1Program for Evolutionary Dynamics, Department of Mathematics, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA

3Department of Biomedical Informatics, Columbia University Medical Center, New York, NY 10032, USA

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Dmitri A. Petrov

4Department of Biology, Stanford University, Stanford, CA 94305, USA

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Martin A. Nowak

1Program for Evolutionary Dynamics, Department of Mathematics, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA

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Pleuni Pennings

4Department of Biology, Stanford University, Stanford, CA 94305, USA

5Department of Biology, San Francisco State University, San Francisco, CA 94132, USA

6Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA

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Imperfect drug penetration leads to spatial monotherapy and rapid evolution of multi-drug resistance

Stefany Moreno-Gamez, Alison L. Hill, Daniel I. S. Rosenbloom, Dmitri A. Petrov, Martin A. Nowak, Pleuni Pennings

bioRxiv 013003; doi: https://doi.org/10.1101/013003

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Imperfect drug penetration leads to spatial monotherapy and rapid evolution of multi-drug resistance

Stefany Moreno-Gamez, Alison L. Hill, Daniel I. S. Rosenbloom, Dmitri A. Petrov, Martin A. Nowak, Pleuni Pennings

bioRxiv 013003; doi: https://doi.org/10.1101/013003

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