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Imperfect drug penetration leads to spatial monotherapy and rapid evolution of multi-drug resistance
Stefany Moreno-Gamez, Alison L. Hill, Daniel I. S. Rosenbloom, Dmitri A. Petrov, Martin A. Nowak, Pleuni Pennings
doi: https://doi.org/10.1101/013003
Stefany Moreno-Gamez
1Program for Evolutionary Dynamics, Department of Mathematics, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
2Centre for Ecological and Evolutionary Studies, University of Groningen, Groningen, 9747 AG, Netherlands
Alison L. Hill
1Program for Evolutionary Dynamics, Department of Mathematics, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
Daniel I. S. Rosenbloom
1Program for Evolutionary Dynamics, Department of Mathematics, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
3Department of Biomedical Informatics, Columbia University Medical Center, New York, NY 10032, USA
Dmitri A. Petrov
4Department of Biology, Stanford University, Stanford, CA 94305, USA
Martin A. Nowak
1Program for Evolutionary Dynamics, Department of Mathematics, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
Pleuni Pennings
4Department of Biology, Stanford University, Stanford, CA 94305, USA
5Department of Biology, San Francisco State University, San Francisco, CA 94132, USA
6Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
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Posted December 19, 2014.
Imperfect drug penetration leads to spatial monotherapy and rapid evolution of multi-drug resistance
Stefany Moreno-Gamez, Alison L. Hill, Daniel I. S. Rosenbloom, Dmitri A. Petrov, Martin A. Nowak, Pleuni Pennings
bioRxiv 013003; doi: https://doi.org/10.1101/013003
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