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Umbilical cord occlusions in near-term ovine fetus induce increased beat-to-beat heart rate variability correlating to decreases in neuroinflammation: a case for the afferent cholinergic anti-inflammatory pathway?

M. G. Frasch, M. Szynkaruk, A.P. Prout, K. Nygard, R. Veldhuizen, R. Hammond, B.S Richardson
doi: https://doi.org/10.1101/013169
M. G. Frasch
1Dept. of Obstetrics and Gynaecology, Dept. of Neurosciences, CHU Ste-Justine Research Centre, Faculty of Medicine
2Animal Reproduction Research Centre (CRRA), Faculty of Veterinary Medicine, Université de Montréal, Montréal, QC, Canada
3 Dept. of Obstetrics and Gynaecology, Lawson Health Research Institute
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M. Szynkaruk
3 Dept. of Obstetrics and Gynaecology, Lawson Health Research Institute
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A.P. Prout
3 Dept. of Obstetrics and Gynaecology, Lawson Health Research Institute
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K. Nygard
4Microscopy
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  • For correspondence: Imaging@Biotron
R. Veldhuizen
5 Dept. of Physiology and Pharmacology
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R. Hammond
6 Dept. Of Pathology, University of Western Ontario, London, ON, Canada
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B.S Richardson
3 Dept. of Obstetrics and Gynaecology, Lawson Health Research Institute
5 Dept. of Physiology and Pharmacology
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Abstract

Supported by grants from the Canadian Institute of Health Research (CIHR) and Lawson Health Research Institute (LHRI) Internal Research Fund (MGF and BSR); CIHR, Fonds de la recherche en santé du Québec (FRSQ) (MGF). BSR is the recipient of the Canada Research Chair in Fetal and Neonatal Health and Development.

Neuroinflammation in utero may contribute to brain injury resulting in life long neurological disabilities. The pivotal role of the efferent cholinergic anti-inflammatory pathway (CAP) in controlling inflammation has been described in adults, but its importance in the fetus is unknown. Moreover, it is unknown whether CAP may also exert anti-inflammatory effects on the brain via CAP’s afferent component of the vagus nerve. Based on multiple clinical studies in adults and our own work in fetal autonomic nervous system, we gauged the degree of CAP activity in vivo using heart rate variability measures reflecting fluctuations in vagus nerve activity. Measuring microglial activation in the ovine fetal brain near-term, we show in vivo that afferent fetal CAP may translate increased vagal cholinergic signaling into suppression of cerebral inflammation in response to near-term hypoxic acidemia as might occur during labour. Our findings suggest a new control mechanism of fetal neuroinflammation via the vagus nerve, providing novel possibilities for its non-invasive monitoring in utero and for targeted treatment.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted January 26, 2015.
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Umbilical cord occlusions in near-term ovine fetus induce increased beat-to-beat heart rate variability correlating to decreases in neuroinflammation: a case for the afferent cholinergic anti-inflammatory pathway?
M. G. Frasch, M. Szynkaruk, A.P. Prout, K. Nygard, R. Veldhuizen, R. Hammond, B.S Richardson
bioRxiv 013169; doi: https://doi.org/10.1101/013169
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Umbilical cord occlusions in near-term ovine fetus induce increased beat-to-beat heart rate variability correlating to decreases in neuroinflammation: a case for the afferent cholinergic anti-inflammatory pathway?
M. G. Frasch, M. Szynkaruk, A.P. Prout, K. Nygard, R. Veldhuizen, R. Hammond, B.S Richardson
bioRxiv 013169; doi: https://doi.org/10.1101/013169

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