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Rethinking inheritance, yet again: inheritomes, contextomes and dynamic phenotypes

N. G. Prasad, Sutirth Dey, Amitabh Joshi, T. N. C. Vidya
doi: https://doi.org/10.1101/013367
N. G. Prasad
1Department of Biological Sciences, Indian Institute of Science Education and Research Mohali, Knowledge City, Sector 81, SAS Nagar, P.O. Manauli, Mohali, Punjab 140 306, India.
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Sutirth Dey
2Population Biology Laboratory, Biology Division, Indian Institute of Science Education and Research Pune, Dr. Homi Bhabha Road, Pune 411 008, India.
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Amitabh Joshi
3Evolutionary Biology Laboratory, Evolutionary and Organismal Biology Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur P.O., Bengaluru 560 064, India.
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T. N. C. Vidya
4Animal Behaviour and Sociogenetics Laboratory, Evolutionary and Organismal Biology Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur P.O., Bengaluru 560 064, India.
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  • For correspondence: tncvidya@jncasr.ac.in tncvidya@gmail.com
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Abstract

In recent years, there have been many calls for an extended evolutionary synthesis, based in part upon growing evidence for non-genetic mechanisms of inheritance, i.e., similarities in phenotype between parents and offspring that are not due to shared genes. While there has been an impressive marshalling of evidence for diverse forms of non-genetic inheritance (epigenetic, ecological, behavioural, symbolic), there have been relatively few studies trying to integrate the different forms of inheritance into a common conceptual structure, a development that would be important to formalizing elements of the extended evolutionary synthesis. Here, we propose a framework for an extended view of inheritance and introduce some conceptual distinctions that we believe are important to this issue. In this framework, the phenotype is conceived of as a dynamic entity, its state at any point in time resulting from intertwined effects of previous phenotypic state, and of hereditary materials (DNA and otherwise) and environment. We contrast our framework with the standard gene-based view of inheritance, and also discuss our framework in the specific context of recent attempts to accommodate non-genetic inheritance within the framework of classical quantitative genetics and the Price equation. In particular, we believe that the extended view of inheritance and effects on the phenotype developed here is particularly well-suited to individual-based simulation studies of evolutionary dynamics. The results of such simulations, in turn, could be useful for assessing how well extended models based on quantitative genetics or the Price equation perform at capturing complex evolutionary dynamics.

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Posted April 08, 2015.
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Rethinking inheritance, yet again: inheritomes, contextomes and dynamic phenotypes
N. G. Prasad, Sutirth Dey, Amitabh Joshi, T. N. C. Vidya
bioRxiv 013367; doi: https://doi.org/10.1101/013367
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Rethinking inheritance, yet again: inheritomes, contextomes and dynamic phenotypes
N. G. Prasad, Sutirth Dey, Amitabh Joshi, T. N. C. Vidya
bioRxiv 013367; doi: https://doi.org/10.1101/013367

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