Evolution of Conditional Cooperativity Between HOXA11 and FOXO1 Through Allosteric Regulation

Mauris C. Nnamani; Soumya Ganguly; Vincent J. Lynch; Laura S. Mizoue; Yingchun Tong; Heather L. Darling; Monika Fuxreiter; Jens Meiler; Günter P. Wagner

doi:10.1101/014381

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Evolution of Conditional Cooperativity Between HOXA11 and FOXO1 Through Allosteric Regulation

Mauris C. Nnamani, Soumya Ganguly, Vincent J. Lynch, Laura S. Mizoue, Yingchun Tong, Heather L. Darling, Monika Fuxreiter, Jens Meiler, Günter P. Wagner

doi: https://doi.org/10.1101/014381

Mauris C. Nnamani

1Yale Systems Biology Institute and Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, 06511 USA

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Soumya Ganguly

2Departments of Chemistry, Pharmacology and Biomedical Informatics; Center for Structural Biology and Institute of Chemical Biology, Vanderbilt University, TN 37232, USA

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Vincent J. Lynch

3Department of Human Genetics, The University of Chicago, 920 E. 58th Street, CLSC 319C, Chicago, IL 60637 USA

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Laura S. Mizoue

4Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80303

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Yingchun Tong

1Yale Systems Biology Institute and Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, 06511 USA

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Heather L. Darling

2Departments of Chemistry, Pharmacology and Biomedical Informatics; Center for Structural Biology and Institute of Chemical Biology, Vanderbilt University, TN 37232, USA

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Monika Fuxreiter

5MTA-DE Momentum Laboratory of Protein Dynamics, University of Debrecen, H-4032 Debrecen, Nagyerdei krt 98, Hungary

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Jens Meiler

2Departments of Chemistry, Pharmacology and Biomedical Informatics; Center for Structural Biology and Institute of Chemical Biology, Vanderbilt University, TN 37232, USA

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For correspondence: gunter.wagner@yale.edu jens.meiler@vanderbilt.edu

Günter P. Wagner

1Yale Systems Biology Institute and Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, 06511 USA

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For correspondence: gunter.wagner@yale.edu jens.meiler@vanderbilt.edu

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Posted January 26, 2015.

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Evolution of Conditional Cooperativity Between HOXA11 and FOXO1 Through Allosteric Regulation

Mauris C. Nnamani, Soumya Ganguly, Vincent J. Lynch, Laura S. Mizoue, Yingchun Tong, Heather L. Darling, Monika Fuxreiter, Jens Meiler, Günter P. Wagner

bioRxiv 014381; doi: https://doi.org/10.1101/014381

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Evolution of Conditional Cooperativity Between HOXA11 and FOXO1 Through Allosteric Regulation

Mauris C. Nnamani, Soumya Ganguly, Vincent J. Lynch, Laura S. Mizoue, Yingchun Tong, Heather L. Darling, Monika Fuxreiter, Jens Meiler, Günter P. Wagner

bioRxiv 014381; doi: https://doi.org/10.1101/014381

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