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Network analysis of genome-wide selective constraint reveals a gene network active in early fetal brain intolerant of mutation

Jinmyung Choi, Parisa Shooshtari, Kaitlin E Samocha, Mark J Daly, Chris Cotsapas
doi: https://doi.org/10.1101/017277
Jinmyung Choi
1Department of Neurology, Yale School of Medicine, New Haven CT, USA
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Parisa Shooshtari
1Department of Neurology, Yale School of Medicine, New Haven CT, USA
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Kaitlin E Samocha
2Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
3Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
4Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
5Program in Genetics and Genomics, Biological and Biomedical Sciences, Harvard Medical School, Boston, Massachusetts, USA
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Mark J Daly
2Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
3Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
4Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
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Chris Cotsapas
1Department of Neurology, Yale School of Medicine, New Haven CT, USA
2Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
3Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
4Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
6Department of Genetics, Yale School of Medicine, New Haven CT, USA
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Article Information

doi 
https://doi.org/10.1101/017277
History 
  • March 29, 2015.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Jinmyung Choi1,
  2. Parisa Shooshtari1,
  3. Kaitlin E Samocha2,3,4,5,
  4. Mark J Daly2,3,4 and
  5. Chris Cotsapas1,2,3,4,6
  1. 1Department of Neurology, Yale School of Medicine, New Haven CT, USA
  2. 2Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
  3. 3Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
  4. 4Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
  5. 5Program in Genetics and Genomics, Biological and Biomedical Sciences, Harvard Medical School, Boston, Massachusetts, USA
  6. 6Department of Genetics, Yale School of Medicine, New Haven CT, USA
  1. Correspondence to CC, cotsapas{at}broadinstitute.org
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Posted March 29, 2015.
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Network analysis of genome-wide selective constraint reveals a gene network active in early fetal brain intolerant of mutation
Jinmyung Choi, Parisa Shooshtari, Kaitlin E Samocha, Mark J Daly, Chris Cotsapas
bioRxiv 017277; doi: https://doi.org/10.1101/017277
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Network analysis of genome-wide selective constraint reveals a gene network active in early fetal brain intolerant of mutation
Jinmyung Choi, Parisa Shooshtari, Kaitlin E Samocha, Mark J Daly, Chris Cotsapas
bioRxiv 017277; doi: https://doi.org/10.1101/017277

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