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MicroRNAs provide the first evidence of genetic link between diapause and aging in vertebrates

Luca Dolfi, Mario Baumgart, Marco Groth, Roberto Ripa, Matthias Platzer, Alessandro Cellerino
doi: https://doi.org/10.1101/017848
Luca Dolfi
1Scuola Normale Superiore, Pisa, Italy
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Mario Baumgart
2Fritz Lipmann Institute for Age Research, Leibniz Institute, Jena
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Marco Groth
2Fritz Lipmann Institute for Age Research, Leibniz Institute, Jena
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Roberto Ripa
1Scuola Normale Superiore, Pisa, Italy
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Matthias Platzer
2Fritz Lipmann Institute for Age Research, Leibniz Institute, Jena
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Alessandro Cellerino
1Scuola Normale Superiore, Pisa, Italy
2Fritz Lipmann Institute for Age Research, Leibniz Institute, Jena
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Summary

Diapause and aging are controlled by overlapping genetic mechanisms in C.elegans and these include microRNAs (miRNAs). Here, we investigated miRNA regulation in embryos of annual killifish that naturally undergo diapause to overcome desiccation of their habitats. We compared miRNA expression in diapausing and non-diapausing embryos in three independent lineages of killifish. We identified 13 miRNAs with similar regulation in all three lineages. One of these is miR-430, which is known as key regulator of early embryonic development in fish. We further tested whether this regulation overlaps with the aging-dependent regulation of miRNAs in one annual species: Nothobranchius furzeri. We found that miR-101a and miR-18a are regulated in the same direction during diapause and aging. These results provide the first evidence that overlapping genetic networks control diapause and aging in vertebrates and suggest that diapause mimics aging to some extent.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted April 10, 2015.
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MicroRNAs provide the first evidence of genetic link between diapause and aging in vertebrates
Luca Dolfi, Mario Baumgart, Marco Groth, Roberto Ripa, Matthias Platzer, Alessandro Cellerino
bioRxiv 017848; doi: https://doi.org/10.1101/017848
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MicroRNAs provide the first evidence of genetic link between diapause and aging in vertebrates
Luca Dolfi, Mario Baumgart, Marco Groth, Roberto Ripa, Matthias Platzer, Alessandro Cellerino
bioRxiv 017848; doi: https://doi.org/10.1101/017848

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