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Coalescent times and patterns of genetic diversity in species with facultative sex: effects of gene conversion, population structure and heterogeneity

Matthew Hartfield, Stephen I. Wright, Aneil F. Agrawal
doi: https://doi.org/10.1101/019158
Matthew Hartfield
*Department of Ecology and Evolutionary Biology, University of Toronto, Ontario, Canada
†Bioinformatics Research Centre, University of Aarhus, 8000C Aarhus, Denmark
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  • For correspondence: matthew.hartfield@utoronto.ca
Stephen I. Wright
*Department of Ecology and Evolutionary Biology, University of Toronto, Ontario, Canada
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Aneil F. Agrawal
*Department of Ecology and Evolutionary Biology, University of Toronto, Ontario, Canada
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Abstract

Many diploid organisms undergo facultative sexual reproduction. However, little is currently known concerning the distribution of neutral genetic variation amongst facultative sexuals except in very simple cases. Under-standing this distribution is important when making inferences about rates of sexual reproduction, effective population size and demographic history. Here, we extend coalescent theory in diploids with facultative sex to consider gene conversion, selfing, population subdivision, and temporal and spatial heterogeneity in rates of sex. In addition to analytical results for two-sample coalescent times, we outline a coalescent algorithm that accommodates the complexities arising from partial sex; this algorithm can be used to generate multi-sample coalescent distributions. A key result is that when sex is rare, gene conversion becomes a significant force in reducing diversity within individuals, which can remove genomic signatures of infrequent sex (the ‘Meselson Effect’) or entirely reverse the predictions. Our models offer improved methods for assessing the null model (I.e. neutrality) of patterns of molecular variation in facultative sexuals.

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  • Website for simulation code: To Be Confirmed

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted May 10, 2015.
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Coalescent times and patterns of genetic diversity in species with facultative sex: effects of gene conversion, population structure and heterogeneity
Matthew Hartfield, Stephen I. Wright, Aneil F. Agrawal
bioRxiv 019158; doi: https://doi.org/10.1101/019158
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Coalescent times and patterns of genetic diversity in species with facultative sex: effects of gene conversion, population structure and heterogeneity
Matthew Hartfield, Stephen I. Wright, Aneil F. Agrawal
bioRxiv 019158; doi: https://doi.org/10.1101/019158

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