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Worldwide population structure, long term demography, and local adaptation of Helicobacter pylori

Valeria Montano, View ORCID ProfileXavier Didelot, View ORCID ProfileMatthieu Foll, View ORCID ProfileBodo Linz, View ORCID ProfileRichard Reinhardt, View ORCID ProfileSebastian Suerbaum, View ORCID ProfileYoshan Moodley, View ORCID ProfileJeffrey D. Jensen
doi: https://doi.org/10.1101/019430
Valeria Montano
§Konrad Lorenz Institute for Ethology, Department of Integrative Biology and Evolution, University of Veterinary Medicine Vienna, Austria
1Department of Ecology and Evolution, University of Lausanne, Lausanne, Switzerland
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Xavier Didelot
¥Department of Infectious Disease Epidemiology, Imperial College London, London W2 1PG, United Kingdom
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Matthieu Foll
*School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
¥¥Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland
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Bodo Linz
¤Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America
**Max Planck Institute for Infection Biology, Department of Molecular Biology, Berlin, Germany
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Richard Reinhardt
§§Max Planck Genome centre Cologne, D-50829 Cologne, Germany
¤¤Max Planck Institute for Molecular Genetics, D-14195 Berlin, Germany
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Sebastian Suerbaum
§§§Hannover Medical School, Institute of Medical Microbiology and Hospital Epidemiology, Hannover, Germany.
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Yoshan Moodley
§Konrad Lorenz Institute for Ethology, Department of Integrative Biology and Evolution, University of Veterinary Medicine Vienna, Austria
**Max Planck Institute for Infection Biology, Department of Molecular Biology, Berlin, Germany
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  • For correspondence: jeffrey.jensen@epfl.ch yoshan.moodley@vetmeduni.ac.at
Jeffrey D. Jensen
*School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
¥¥Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland
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  • For correspondence: jeffrey.jensen@epfl.ch yoshan.moodley@vetmeduni.ac.at
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Abstract

Helicobacter pylori is an important human pathogen associated with serious gastric diseases. Owing to its medical importance and close relationship with its human host, understanding genomic patterns of global and local adaptation in H. pylori may be of particular significance for both clinical and evolutionary studies. Here we present the first such whole-genome analysis of 60 globally distributed strains, from which we inferred worldwide population structure and demographic history and shed light on interesting global and local events of positive selection, with particular emphasis on the evolution of San-associated lineages. Our results indicate a more ancient origin for the association of humans and H. pylori than previously thought. We identify several important perspectives for future clinical research on candidate selected regions that include both previously characterized genes (e.g. transcription elongation factor NusA and tumor Necrosis Factor Alpha-Inducing Protein Tipα) and hitherto unknown functional genes.

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Posted May 18, 2015.
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Worldwide population structure, long term demography, and local adaptation of Helicobacter pylori
Valeria Montano, Xavier Didelot, Matthieu Foll, Bodo Linz, Richard Reinhardt, Sebastian Suerbaum, Yoshan Moodley, Jeffrey D. Jensen
bioRxiv 019430; doi: https://doi.org/10.1101/019430
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Worldwide population structure, long term demography, and local adaptation of Helicobacter pylori
Valeria Montano, Xavier Didelot, Matthieu Foll, Bodo Linz, Richard Reinhardt, Sebastian Suerbaum, Yoshan Moodley, Jeffrey D. Jensen
bioRxiv 019430; doi: https://doi.org/10.1101/019430

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