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Genetic interactions contribute less than additive effects to quantitative trait variation in yeast

Joshua S. Bloom, Iulia Kotenko, Meru J. Sadhu, Sebastian Treusch, Frank W. Albert, Leonid Kruglyak
doi: https://doi.org/10.1101/019513
Joshua S. Bloom
1Department of Human Genetics, University of California, Los Angeles, Los Angeles, California 90095, USA
2Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, California 90095, USA
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Iulia Kotenko
3Department of Molecular Biology, Princeton University, Princeton, New Jersey 08540, USA
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Meru J. Sadhu
1Department of Human Genetics, University of California, Los Angeles, Los Angeles, California 90095, USA
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Sebastian Treusch
4Twist Bioscience, San Francisco, California 94158, USA
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Frank W. Albert
1Department of Human Genetics, University of California, Los Angeles, Los Angeles, California 90095, USA
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Leonid Kruglyak
1Department of Human Genetics, University of California, Los Angeles, Los Angeles, California 90095, USA
2Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, California 90095, USA
5Department of Biological Chemistry, University of California, Los Angeles, California 90095, USA
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  • For correspondence: lkruglyak@mednet.ucla.edu
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Abstract

Genetic mapping studies of quantitative traits typically focus on detecting loci that contribute additively to trait variation. Genetic interactions are often proposed as a contributing factor to trait variation, but the relative contribution of interactions to trait variation is a subject of debate. Here, we use a very large cross between two yeast strains to accurately estimate the fraction of phenotypic variance due to pairwise QTL-QTL interactions for 20 quantitative traits. We find that this fraction is 9% on average, substantially less than the contribution of additive QTL (43%). Statistically significant QTL-QTL pairs typically have small individual effect sizes, but collectively explain 40% of the pairwise interaction variance. We show that pairwise interaction variance is largely explained by pairs of loci at least one of which has a significant additive effect. These results refine our understanding of the genetic architecture of quantitative traits and help guide future mapping studies.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted October 08, 2015.
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Genetic interactions contribute less than additive effects to quantitative trait variation in yeast
Joshua S. Bloom, Iulia Kotenko, Meru J. Sadhu, Sebastian Treusch, Frank W. Albert, Leonid Kruglyak
bioRxiv 019513; doi: https://doi.org/10.1101/019513
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Genetic interactions contribute less than additive effects to quantitative trait variation in yeast
Joshua S. Bloom, Iulia Kotenko, Meru J. Sadhu, Sebastian Treusch, Frank W. Albert, Leonid Kruglyak
bioRxiv 019513; doi: https://doi.org/10.1101/019513

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