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A Unified Architecture of Transcriptional Regulatory Elements

View ORCID ProfileRobin Andersson, View ORCID ProfileAlbin Sandelin, View ORCID ProfileCharles G. Danko
doi: https://doi.org/10.1101/019844
Robin Andersson
1The Bioinformatics Centre, Department of Biology, University of Copenhagen, Copenhagen, Denmark
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  • For correspondence: robin@binf.ku.dk dankoc@gmail.com
Albin Sandelin
1The Bioinformatics Centre, Department of Biology, University of Copenhagen, Copenhagen, Denmark
2Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark
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Charles G. Danko
3Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
4Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
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  • For correspondence: robin@binf.ku.dk dankoc@gmail.com
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Abstract

Gene expression is precisely controlled in time and space through the integration of signals that act at gene promoters and gene-distal enhancers. Classically, promoters and enhancers are considered separate classes of regulatory elements, often distinguished by histone modifications. However, recent studies have revealed broad similarities between enhancers and promoters, blurring the distinction: active enhancers often initiate transcription, and some gene promoters have the potential of enhancing transcriptional output of other promoters. Here, we propose a model in which promoters and enhancers are considered a single class of functional element, with a unified architecture for transcription initiation. The context of interacting regulatory elements, and surrounding sequences, determine local transcriptional output as well as the enhancer and promoter activities of individual elements.

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Posted May 26, 2015.
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A Unified Architecture of Transcriptional Regulatory Elements
Robin Andersson, Albin Sandelin, Charles G. Danko
bioRxiv 019844; doi: https://doi.org/10.1101/019844
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A Unified Architecture of Transcriptional Regulatory Elements
Robin Andersson, Albin Sandelin, Charles G. Danko
bioRxiv 019844; doi: https://doi.org/10.1101/019844

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