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The weighting is the hardest part: on the behavior of the likelihood ratio test and score test under weight misspecification in rare variant association studies
Camelia C. Minică, Giulio Genovese, Dorret I. Boomsma, Christina M. Hultman, René Pool, Jacqueline M. Vink, Conor V. Dolan, Benjamin M. Neale
doi: https://doi.org/10.1101/020198
Camelia C. Minică
1Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
Giulio Genovese
2The Stanley Center for Psychiatric Research, Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, MA
3The Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, MA
4Department of Genetics, Harvard Medical School, Cambridge, MA
Dorret I. Boomsma
1Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
Christina M. Hultman
5Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm
René Pool
1Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
Jacqueline M. Vink
1Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
Conor V. Dolan
1Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
Benjamin M. Neale
2The Stanley Center for Psychiatric Research, Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, MA
3The Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, MA
6The Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
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Posted June 02, 2015.
The weighting is the hardest part: on the behavior of the likelihood ratio test and score test under weight misspecification in rare variant association studies
Camelia C. Minică, Giulio Genovese, Dorret I. Boomsma, Christina M. Hultman, René Pool, Jacqueline M. Vink, Conor V. Dolan, Benjamin M. Neale
bioRxiv 020198; doi: https://doi.org/10.1101/020198
The weighting is the hardest part: on the behavior of the likelihood ratio test and score test under weight misspecification in rare variant association studies
Camelia C. Minică, Giulio Genovese, Dorret I. Boomsma, Christina M. Hultman, René Pool, Jacqueline M. Vink, Conor V. Dolan, Benjamin M. Neale
bioRxiv 020198; doi: https://doi.org/10.1101/020198
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