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Haplotypes of common SNPs can explain missing heritability of complex diseases
Gaurav Bhatia, Alexander Gusev, Po-Ru Loh, Bjarni J. Vilhjálmsson, Stephan Ripke, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Shaun Purcell, Eli Stahl, Mark Daly, Teresa R de Candia, Kenneth S. Kendler, Michael C O’Donovan, Sang Hong Lee, Naomi R. Wray, Benjamin M Neale, Matthew C. Keller, Noah A. Zaitlen, Bogdan Pasaniuc, Jian Yang, Alkes L. Price
doi: https://doi.org/10.1101/022418
Gaurav Bhatia
1Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA
2Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA
Alexander Gusev
1Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA
2Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA
Po-Ru Loh
1Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA
2Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA
Bjarni J. Vilhjálmsson
1Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA
2Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA
3Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark
Stephan Ripke
4Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Shaun Purcell
2Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA
5Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
6Department of Psychiatry, Mt. Sinai Hospital, NY, USA
7Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, NY, USA
Eli Stahl
2Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA
8Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
9Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
Mark Daly
2Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA
4Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Teresa R de Candia
10Department of Psychology and Neuroscience, University of Colorado, Boulder, Boulder, CO, USA
Kenneth S. Kendler
11Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA
Michael C O’Donovan
12MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK
Sang Hong Lee
13Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia
Naomi R. Wray
13Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia
Benjamin M Neale
2Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA
4Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Matthew C. Keller
14Institute for Behavioral Genetics, University of Colorado, Boulder, Boulder, CO, USA
Noah A. Zaitlen
15Lung Biology Center, School of Medicine, University of California, San Francisco, San Francisco, CA, USA
Bogdan Pasaniuc
16Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA, USA
Jian Yang
12MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK
17The University of Queensland Diamantina Institute, The Translation Research Institute, Brisbane, Queensland, Australia
Alkes L. Price
1Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA
2Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA
18Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA
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Posted July 12, 2015.
Haplotypes of common SNPs can explain missing heritability of complex diseases
Gaurav Bhatia, Alexander Gusev, Po-Ru Loh, Bjarni J. Vilhjálmsson, Stephan Ripke, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Shaun Purcell, Eli Stahl, Mark Daly, Teresa R de Candia, Kenneth S. Kendler, Michael C O’Donovan, Sang Hong Lee, Naomi R. Wray, Benjamin M Neale, Matthew C. Keller, Noah A. Zaitlen, Bogdan Pasaniuc, Jian Yang, Alkes L. Price
bioRxiv 022418; doi: https://doi.org/10.1101/022418
Haplotypes of common SNPs can explain missing heritability of complex diseases
Gaurav Bhatia, Alexander Gusev, Po-Ru Loh, Bjarni J. Vilhjálmsson, Stephan Ripke, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Shaun Purcell, Eli Stahl, Mark Daly, Teresa R de Candia, Kenneth S. Kendler, Michael C O’Donovan, Sang Hong Lee, Naomi R. Wray, Benjamin M Neale, Matthew C. Keller, Noah A. Zaitlen, Bogdan Pasaniuc, Jian Yang, Alkes L. Price
bioRxiv 022418; doi: https://doi.org/10.1101/022418
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