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Polymorphisms in oxidative pathway related genes and susceptibility to inflammatory bowel disease

Nezha Senhaji, Sellama Nadifi, Aurora Serrano, Daniel León Rodríguez, Nadia Serbati, Mehdi Karkouri, Wafaa Badre, Javier Martin
doi: https://doi.org/10.1101/022681
Nezha Senhaji
1Laboratory of Genetics and Molecular pathologies, Faculty of Medecine and Pharmacy of Casablanca, Morocco
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Sellama Nadifi
1Laboratory of Genetics and Molecular pathologies, Faculty of Medecine and Pharmacy of Casablanca, Morocco
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Aurora Serrano
2Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, P.T.S. Granada, Granada, Spain
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Daniel León Rodríguez
2Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, P.T.S. Granada, Granada, Spain
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Nadia Serbati
1Laboratory of Genetics and Molecular pathologies, Faculty of Medecine and Pharmacy of Casablanca, Morocco
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Mehdi Karkouri
3Pathology Department, CHU Ibn Rochd, Casablanca, Morocco
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Wafaa Badre
4Gastroenterology Department, CHU Ibn Rochd, Casablanca, Morocco
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Javier Martin
2Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, P.T.S. Granada, Granada, Spain
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ABSTRACT

Objective To better characterize the genetic factors, implicated in oxidative pathway, determining susceptibility to inflammatory bowel disease (IBD), we assessed for the first time the potential role of NOS2A, HIF1A and NFKB1 polymorphisms on the risk of developing IBD in Moroccan population.

Methods The distribution of (TAAA)n_rs12720460 and (CCTTT)n_rs3833912 NOS2A microsatellite repeats, HIF-1A_rs11549467 and NFKB1–94ins/delATTG_rs28362491 was analyzed in 507 subjects grouped in 199 IBD and 308 healthy controls. Genotyping was performed with polymerase chain reaction-fluorescent method and the TaqMan® allelic discrimination technology.

Results The allele and genotype frequencies of HIF1A_rs11549467, NFKB1_rs28362491 and NOS2A_(TAAA)n did not differ significantly between patients and controls. Analysis of NOS2A_(CCTTT)n markers evidenced differences between patients and healthy controls. A preferential presence of the (CCTTT)8 (P=0.02; OR=1.71, 95%CI=1.07–2.74), (CCTTT)14 (P=0.02; OR=1.71, 95%CI=1.06–2.76) alleles in IBD, (CCTTT)8 (P=0.008; OR=1.95, 95%CI=1.17–3.23) in CD and (CCTTT)7 (P=0.009; OR = 7.61, 95%CI=1.25-46.08), (CCTTT)11 (P=0.05 ; OR= 0.51, 95%CI=0.25-1.01), (CCTTT)14 (P=0.02 ; OR= 2.05, 95%CI=1.07-3.94), (CCTTT)15 (P=0.01 ; OR= 2.25, 95%CI=1.16-4.35) repeats in UC patients indicated its possible association with higher disease risk which need to be confirmed in a larger sample size.

Conclusion Our results suggest that the NOS2A_(CCTTT)n gene variations may influence IBD susceptibility in the Moroccan population.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted July 17, 2015.
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Polymorphisms in oxidative pathway related genes and susceptibility to inflammatory bowel disease
Nezha Senhaji, Sellama Nadifi, Aurora Serrano, Daniel León Rodríguez, Nadia Serbati, Mehdi Karkouri, Wafaa Badre, Javier Martin
bioRxiv 022681; doi: https://doi.org/10.1101/022681
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Polymorphisms in oxidative pathway related genes and susceptibility to inflammatory bowel disease
Nezha Senhaji, Sellama Nadifi, Aurora Serrano, Daniel León Rodríguez, Nadia Serbati, Mehdi Karkouri, Wafaa Badre, Javier Martin
bioRxiv 022681; doi: https://doi.org/10.1101/022681

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