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Ancient trans-acting siRNAs Confer Robustness and Sensitivity onto the Auxin Response

View ORCID ProfileYevgeniy Plavskin, Akitomo Nagashima, Pierre-François Perroud, Mitsuyasu Hasebe, Ralph S. Quatrano, Gurinder S. Atwal, Marja C.P. Timmermans
doi: https://doi.org/10.1101/024307
Yevgeniy Plavskin
Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA
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  • ORCID record for Yevgeniy Plavskin
Akitomo Nagashima
National Institute for Basic Biology, Okazaki, JapanExploratory Research for Advanced Technology, Japan Science and Technology Agency, Okazaki, Japan
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Pierre-François Perroud
Department of Biology, Washington University, St. Louis, MO, USA
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Mitsuyasu Hasebe
National Institute for Basic Biology, Okazaki, JapanExploratory Research for Advanced Technology, Japan Science and Technology Agency, Okazaki, Japan
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Ralph S. Quatrano
Department of Biology, Washington University, St. Louis, MO, USA
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Gurinder S. Atwal
Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA
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Marja C.P. Timmermans
Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USACenter for Plant Molecular Biology, University of Tübingen, Tübingen, Germany
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ABSTRACT

Novel developmental programs often evolve via cooption of existing genetic networks. To understand this process, we explored cooption of the TAS3 tasiRNA pathway in the moss Physcomitrella patens. We find an ancestral function for this repeatedly redeployed pathway in the spatial regulation of a conserved set of Auxin Response Factors. In moss, this results in stochastic patterning of the filamentous protonemal tissue. Through modeling and experimentation, we demonstrate that tasiRNA regulation confers sensitivity and robustness onto the auxin response. Increased auxin sensitivity parallels increased developmental sensitivity to nitrogen, a key environmental signal. We propose that the properties lent to the auxin response network, along with the ability to stochastically modulate development in response to environmental cues, have contributed to the tasiRNA-ARF module’s repeated cooption during evolution. The signaling properties of a genetic network, and not just its developmental output, are thus critical to understanding the evolution of multicellular forms.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted February 01, 2016.
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Ancient trans-acting siRNAs Confer Robustness and Sensitivity onto the Auxin Response
Yevgeniy Plavskin, Akitomo Nagashima, Pierre-François Perroud, Mitsuyasu Hasebe, Ralph S. Quatrano, Gurinder S. Atwal, Marja C.P. Timmermans
bioRxiv 024307; doi: https://doi.org/10.1101/024307
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Ancient trans-acting siRNAs Confer Robustness and Sensitivity onto the Auxin Response
Yevgeniy Plavskin, Akitomo Nagashima, Pierre-François Perroud, Mitsuyasu Hasebe, Ralph S. Quatrano, Gurinder S. Atwal, Marja C.P. Timmermans
bioRxiv 024307; doi: https://doi.org/10.1101/024307

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