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Prediction of Primary Somatosensory Neuron Activity During Active Tactile Exploration

Dario Campagner, Mathew Evans, Michael R. Bale, Andrew Erskine, Rasmus S. Petersen
doi: https://doi.org/10.1101/024364
Dario Campagner
Faculty of Life Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
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Mathew Evans
Faculty of Life Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
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Michael R. Bale
Faculty of Life Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UKSchool of Life Sciences, University of Sussex, Brighton, BN1 9QG, UK
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Andrew Erskine
Faculty of Life Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UKThe Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London, NW7 1AA
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Rasmus S. Petersen
Faculty of Life Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
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ABSTRACT

Primary sensory neurons form the interface between world and brain. Their function is well-understood during passive stimulation but, under natural behaving conditions, sense organs are under active, motor control. In an attempt to predict primary neuron firing under natural conditions of sensorimotor integration, we recorded from primary mechanosensory neuronsof awake, head-fixed mice as they explored a pole with their whiskers, and simultaneously measured both whisker motion and forces with high-speed videography. Using Generalised Linear Models, we found that primary neuron responses were poorly predicted by kinematics but well-predicted by rotational forces acting on the whisker: both during touch and free-air whisker motion. These results are discrepant with previous studies of passive stimulation, but could be reconciled by differences in the kinematics-force relationship between active and passive conditions. Thus, simple statistical models can predict rich neural activity elicited by natural, exploratory behaviour involving active movement of the sense organs.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted February 02, 2016.
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Prediction of Primary Somatosensory Neuron Activity During Active Tactile Exploration
Dario Campagner, Mathew Evans, Michael R. Bale, Andrew Erskine, Rasmus S. Petersen
bioRxiv 024364; doi: https://doi.org/10.1101/024364
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Prediction of Primary Somatosensory Neuron Activity During Active Tactile Exploration
Dario Campagner, Mathew Evans, Michael R. Bale, Andrew Erskine, Rasmus S. Petersen
bioRxiv 024364; doi: https://doi.org/10.1101/024364

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