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Gene flow mediates the role of sex chromosome meiotic drive during complex speciation

Colin D. Meiklejohn, Emily L. Landeen, Kathleen E. Gordon, Thomas Rzatkiewicz, Sarah B. Kingan, Anthony J. Geneva, Jeffrey P. Vedanayagam, Christina A. Muirhead, Daniel Garrigan, David L. Stern, Daven C. Presgraves
doi: https://doi.org/10.1101/024711
Colin D. Meiklejohn
1School of Biological Sciences, University of Nebraska, Lincoln, Nebraska, 68588 USA
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  • For correspondence: cmeiklejohn2@unl.edu daven.presgraves@rochester.edu
Emily L. Landeen
2Department of Biology, University of Rochester, Rochester, New York, 14627, USA
4Department of Integrative Biology, University of California, Berkeley, California, 94720, USA
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Kathleen E. Gordon
1School of Biological Sciences, University of Nebraska, Lincoln, Nebraska, 68588 USA
5Department of Molecular Biology and Genetics, Field of Genetics, Genomics, and Development, Cornell University, Ithaca, New York, 14853, USA
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Thomas Rzatkiewicz
2Department of Biology, University of Rochester, Rochester, New York, 14627, USA
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Sarah B. Kingan
2Department of Biology, University of Rochester, Rochester, New York, 14627, USA
6Pacific Biosciences of California, Menlo Park, CA USA
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Anthony J. Geneva
2Department of Biology, University of Rochester, Rochester, New York, 14627, USA
7Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, 02138, USA
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Jeffrey P. Vedanayagam
2Department of Biology, University of Rochester, Rochester, New York, 14627, USA
8Department of Developmental Biology, Sloan-Kettering Institute, New York, NY 10065, USA
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Christina A. Muirhead
2Department of Biology, University of Rochester, Rochester, New York, 14627, USA
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Daniel Garrigan
2Department of Biology, University of Rochester, Rochester, New York, 14627, USA
9AncestryDNA, 153 Townsend Street, San Francisco, CA 94107 USA
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David L. Stern
3Janelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, Virginia, 20147, USA
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Daven C. Presgraves
2Department of Biology, University of Rochester, Rochester, New York, 14627, USA
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  • For correspondence: cmeiklejohn2@unl.edu daven.presgraves@rochester.edu
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ABSTRACT

During speciation, sex chromosomes often accumulate interspecific genetic incompatibilities faster than the rest of the genome. The drive theory posits that sex chromosomes are susceptible to recurrent bouts of meiotic drive and suppression, causing the evolutionary build-up of divergent cryptic sex-linked drive systems and, incidentally, genetic incompatibilities. To assess the role of drive during speciation, we combine high-resolution genetic mapping of X-linked hybrid male sterility with population genomics analyses of divergence and recent gene flow between the fruitfly species, Drosophila mauritiana and D. simulans. Our findings reveal a high density of genetic incompatibilities and a corresponding dearth of gene flow on the X chromosome. Surprisingly, we find that, rather than contributing to interspecific divergence, a known drive element has recently migrated between species, caused a strong reduction in local divergence, and undermined the evolution of hybrid sterility. Gene flow can therefore mediate the effects of selfish genetic elements during speciation.

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Posted January 31, 2018.
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Gene flow mediates the role of sex chromosome meiotic drive during complex speciation
Colin D. Meiklejohn, Emily L. Landeen, Kathleen E. Gordon, Thomas Rzatkiewicz, Sarah B. Kingan, Anthony J. Geneva, Jeffrey P. Vedanayagam, Christina A. Muirhead, Daniel Garrigan, David L. Stern, Daven C. Presgraves
bioRxiv 024711; doi: https://doi.org/10.1101/024711
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Gene flow mediates the role of sex chromosome meiotic drive during complex speciation
Colin D. Meiklejohn, Emily L. Landeen, Kathleen E. Gordon, Thomas Rzatkiewicz, Sarah B. Kingan, Anthony J. Geneva, Jeffrey P. Vedanayagam, Christina A. Muirhead, Daniel Garrigan, David L. Stern, Daven C. Presgraves
bioRxiv 024711; doi: https://doi.org/10.1101/024711

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