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Limits to adaptation in partially selfing species

Matthew Hartfield, Sylvain Glémin
doi: https://doi.org/10.1101/026146
Matthew Hartfield
1Laboratoire MIVEGEC (UMR CNRS 5290, IRD 224, UM1, UM2), 911 avenue Agropolis, B.P. 64501, 34394 Montpellier cedex 5, France
2Department of Ecology and Evolutionary Biology, University of Toronto, Ontario, Canada
3Bioinformatics Research Centre, University of Aarhus, 8000C Aarhus, Denmark
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  • For correspondence: matthew.hartfield@utoronto.ca
Sylvain Glémin
4Institut des Sciences de l’Evolution de Montpellier, UMR 5554 CNRS, Place Eugéne Bataillon, 34095 Montpellier cedex 5, France
5Department of Ecology and Genetics, Evolutionary Biology Centre, Uppsala University, SE-752 36 Uppsala, Sweden
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Abstract

Single locus theory indicates that selfing species are more able than outcrossing ones to fix emerging recessive beneficial mutations, as they are not masked as heterozygotes. However, partially selfing organisms suffer from relaxed recombination, which reduces overall selection efficiency. Although the effect of linked deleterious alleles on adaptation has previously been studied, the extent to which multiple adaptations interfere in partially selfing organisms is currently unknown. We derive branching-process models to quantify the extent that emergence of a second beneficial allele is obstructed by an existing selective sweep. We consider both the potential loss of the second beneficial mutation if it has a weaker advantage than the first sweep (the ‘stochastic interference effect’), and also the potential replacement of the first sweep if the second mutant is fitter (‘replacement effect’). Overall, the stochastic interference effect has a larger impact on preventing fixation of both adaptive alleles in highly selfing organisms, but the replacement effect can be stronger with multiple mutations. Interference has two opposing effects on Haldane’s Sieve. First, recessive mutants are disproportionally likely to be lost, so it is more likely that only dominant mutations will emerge in outcrossers. Second, with frequent rates of adaptive evolution, outcrossing organisms are more able to fix weak beneficial mutations of any dominance value, contrary to the predictions of Haldane’s Sieve. Our analysis shows that even under low rates of adaptive mutation, interference can be sufficiently strong to greatly limit adaptation in selfing organisms.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted September 06, 2015.
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Limits to adaptation in partially selfing species
Matthew Hartfield, Sylvain Glémin
bioRxiv 026146; doi: https://doi.org/10.1101/026146
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Limits to adaptation in partially selfing species
Matthew Hartfield, Sylvain Glémin
bioRxiv 026146; doi: https://doi.org/10.1101/026146

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