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Structural constraints to information flow within cortical circuits: a TMS/EEG-dMRI study

Enrico Amico, Olivier Bodart, Olivia Gosseries, Lizette Heine, Mario Rosanova, Pieter Van Mierlo, Charlotte Martial, Marcello Massimini, Daniele Marinazzo, Steven Laureys
doi: https://doi.org/10.1101/026419
Enrico Amico
University of Liege and University of Ghent;
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Olivier Bodart
University of Liege;
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Olivia Gosseries
University of Wisconsin and University of Liege;
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Lizette Heine
University of Liege;
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Mario Rosanova
University of Milan;
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Pieter Van Mierlo
University of Ghent
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Charlotte Martial
University of Liege;
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Marcello Massimini
University of Milan;
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Daniele Marinazzo
University of Ghent
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  • For correspondence: daniele.marinazzo@gmail.com
Steven Laureys
University of Liege;
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Abstract

Transcranial magnetic stimulation (TMS) has been used for more than 20 years to investigate brain function by perturbing and observing the consequent behavioral, pathophysiological and electrophysiological modulations. These latter, mainly measured by high-density electroencephalography (hd-EEG), revealed signatures of the functional organization in a brain network. In order to unveil the nature and the underlying mechanism of these signatures, we here mapped TMS-induced hd-EEG changes onto changes in information flow and brain structural architecture, using multimodal modeling of source reconstructed TMS/hd-EEG recordings and diffusion magnetic resonance imaging (dMRI) tractography in a cohort of awake healthy volunteers. We observed that the relationship between information flow and structural connections depend on the stimulation site and on the frequency of the TMS-induced brain rhythms. These findings highlight the importance of taking into account the dynamics of different local oscillations when investigating the mechanisms for integration and segregation of information in the human brain. Our whole-brain analysis sheds light on the function-structure organization of the brain network after TMS, and on the huge variety of information contained in it.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted September 09, 2015.
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Structural constraints to information flow within cortical circuits: a TMS/EEG-dMRI study
Enrico Amico, Olivier Bodart, Olivia Gosseries, Lizette Heine, Mario Rosanova, Pieter Van Mierlo, Charlotte Martial, Marcello Massimini, Daniele Marinazzo, Steven Laureys
bioRxiv 026419; doi: https://doi.org/10.1101/026419
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Structural constraints to information flow within cortical circuits: a TMS/EEG-dMRI study
Enrico Amico, Olivier Bodart, Olivia Gosseries, Lizette Heine, Mario Rosanova, Pieter Van Mierlo, Charlotte Martial, Marcello Massimini, Daniele Marinazzo, Steven Laureys
bioRxiv 026419; doi: https://doi.org/10.1101/026419

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