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Long-delay Learning in Intraoral Conditioned Taste Aversion

View ORCID ProfileThomas A. Houpt, View ORCID ProfileJennifer A. Cassell, View ORCID ProfileStefanie McCormack, View ORCID ProfileBumsup Kwon, View ORCID ProfileGary Tiffany, View ORCID ProfileJeffrey Lorch
doi: https://doi.org/10.1101/026500
Thomas A. Houpt
Department of Biological Science, Program in Neuroscience, Florida State University, Tallahasse, FL, USA
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Jennifer A. Cassell
Department of Biological Science, Program in Neuroscience, Florida State University, Tallahasse, FL, USA
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Stefanie McCormack
Department of Biological Science, Program in Neuroscience, Florida State University, Tallahasse, FL, USA
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Bumsup Kwon
Department of Biological Science, Program in Neuroscience, Florida State University, Tallahasse, FL, USA
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Gary Tiffany
Department of Biological Science, Program in Neuroscience, Florida State University, Tallahasse, FL, USA
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Jeffrey Lorch
Department of Biological Science, Program in Neuroscience, Florida State University, Tallahasse, FL, USA
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Abstract

The cardinal feature of conditioned taste aversion (CTA) learning is the ability of animals to associate the taste or flavor of a food (the conditioned stimulus; CS) with a subsequent toxic effect (unconditioned stimulus; US), even if the toxicity occurs hours later, i.e. after a long delay. Two experiments were conducted which took advantage of the stimulus control afforded by intraoral catheterization to establish the parameters of long-delay learning in intraoral CTA. First, to determine the range of CS-US intervals which supports intraoral conditioning, rats received infusions of 5% sucrose paired with LiCl (76 mg/kg, ip) across a range of delays (0-6 h). Second, to determine the interaction of US dose and delay, rats were conditioned with sucrose paired with different doses of LiCl (19, 38 or 76 mg/kg) at several CS-US intervals (0, 10, or 60 min). Con-ditioning, assessed during a second infusion of sucrose at 48 h post-conditioning, was optimal at 10 min (although not significantly different at intervals between 0 and 60 min). Effectiveness declined at longer delays, such that CTA was not supported at intervals of 3h or greater. The dose-interval function suggested that an increased US can compensate for a longer CS-US interval. Low doses of LiCl induced a long-term CTA at 0-min (19 and 38 mg/kg) or 10-min delays (38 mg/kg), but were not sufficient to induce CTA at longer delays, which required the highest dose (76 mg/kg).

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Posted September 09, 2015.
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Long-delay Learning in Intraoral Conditioned Taste Aversion
Thomas A. Houpt, Jennifer A. Cassell, Stefanie McCormack, Bumsup Kwon, Gary Tiffany, Jeffrey Lorch
bioRxiv 026500; doi: https://doi.org/10.1101/026500
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Long-delay Learning in Intraoral Conditioned Taste Aversion
Thomas A. Houpt, Jennifer A. Cassell, Stefanie McCormack, Bumsup Kwon, Gary Tiffany, Jeffrey Lorch
bioRxiv 026500; doi: https://doi.org/10.1101/026500

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