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A glance at recombination hotspots in the domestic cat

Hasan Alhaddad, Chi Zhang, Bruce Rannala, Leslie A. Lyons
doi: https://doi.org/10.1101/028043
Hasan Alhaddad
1College of Science, Department of Biological Sciences, Kuwait University, Safat, Kuwait, 13060
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Chi Zhang
2Department of Bioinformatics and Genetics, Swedish Museum of Natural History, Box 50007, SE-104 05 Stockholm, Sweden
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Bruce Rannala
3Genome Center and Department of Evolution and Ecology, University of California - Davis, Davis, CA 95616, USA
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Leslie A. Lyons
4Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri-Columbia, Columbia, MO, 65211
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Abstract

Recombination has essential roles in increasing genetic variability within a population and in ensuring successful meiotic events. The objective of this study is to (i) infer the population scaled recombination rate (ρ), and (ii) identify and characterize localities of increased recombination rate for the domestic cat, Felis silvestris catus. SNPs (n = 701) were genotyped in twenty-two cats of Eastern random bred origin. The SNPs covered ten different chromosomal regions (A1, A2, B3, C2, D1, D2, D4, E2, F2, X) with an average region size of 850 Kb and an average SNP density of 70 SNPs/region. The Bayesian method in the program inferRho was used to infer regional population recombination rates and hotspots localities. The regions exhibited variable population recombination rates and four decisive recombination hotspots were identified on cat chromosome A2, D1, and E2 regions. No correlation was detected between the GC content and the locality of recombination spots. The hotspots enclosed L2 LINE elements and MIR and tRNA-Lys SINE elements in agreement with hotspots found in other mammals.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted October 01, 2015.
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A glance at recombination hotspots in the domestic cat
Hasan Alhaddad, Chi Zhang, Bruce Rannala, Leslie A. Lyons
bioRxiv 028043; doi: https://doi.org/10.1101/028043
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A glance at recombination hotspots in the domestic cat
Hasan Alhaddad, Chi Zhang, Bruce Rannala, Leslie A. Lyons
bioRxiv 028043; doi: https://doi.org/10.1101/028043

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