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Reconstructing Genetic History of Siberian and Northeastern European Populations

Emily HM Wong, Andrey Khrunin, Larissa Nichols, Dmitry Pushkarev, Denis Khokhrin, Dmitry Verbenko, Oleg Evgrafov, James Knowles, John Novembre, Svetlana Limborska, Anton Valouev
doi: https://doi.org/10.1101/029421
Emily HM Wong
1Division of Bioinformatics, Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA.
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Andrey Khrunin
2Department of Molecular Bases of Human Genetics, Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russian Federation.
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Larissa Nichols
2Department of Molecular Bases of Human Genetics, Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russian Federation.
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Dmitry Pushkarev
3Illumina, Inc., Advanced Research Group, San Diego, CA, USA.
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Denis Khokhrin
2Department of Molecular Bases of Human Genetics, Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russian Federation.
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Dmitry Verbenko
2Department of Molecular Bases of Human Genetics, Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russian Federation.
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Oleg Evgrafov
4Department of Psychiatry and Behavioral Sciences, Keck School of Medicine, Zilkha Neurogenetic Institute, University of Southern California, CA, USA.
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James Knowles
4Department of Psychiatry and Behavioral Sciences, Keck School of Medicine, Zilkha Neurogenetic Institute, University of Southern California, CA, USA.
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John Novembre
5Department of Human Genetics, University of Chicago, Chicago, IL, USA.
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Svetlana Limborska
2Department of Molecular Bases of Human Genetics, Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russian Federation.
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  • For correspondence: valouev@usc.edu limbor@img.ras.ru
Anton Valouev
1Division of Bioinformatics, Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA.
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  • For correspondence: valouev@usc.edu limbor@img.ras.ru
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ABSTRACT

Siberia and Western Russia are home to over 40 culturally and linguistically diverse indigenous ethnic groups. Yet, genetic variation of peoples from this region is largely uncharacterized. We present whole-genome sequencing data from 28 individuals belonging to 14 distinct indigenous populations from that region. We combine these datasets with additional 32 modern-day and 15 ancient human genomes to build and compare autosomal, Y-DNA and mtDNA trees. Our results provide new links between modern and ancient inhabitants of Eurasia. Siberians share 38% of ancestry with descendants of the 45,000-year-old Ust’-Ishim people, who were previously believed to have no modern-day descendants. Western Siberians trace 57% of their ancestry to the Ancient North Eurasians, represented by the 24,000-year-old Siberian Mal’ta boy. In addition, Siberians admixtures are present in lineages represented by Eastern European hunter-gatherers from Samara, Karelia, Hungary and Sweden (from 8,000-6,600 years ago), as well as Yamnaya culture people (5,300-4,700 years ago) and modern-day northeastern Europeans. These results provide new evidence of ancient gene flow from Siberia into Europe.

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Posted October 20, 2015.
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Reconstructing Genetic History of Siberian and Northeastern European Populations
Emily HM Wong, Andrey Khrunin, Larissa Nichols, Dmitry Pushkarev, Denis Khokhrin, Dmitry Verbenko, Oleg Evgrafov, James Knowles, John Novembre, Svetlana Limborska, Anton Valouev
bioRxiv 029421; doi: https://doi.org/10.1101/029421
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Reconstructing Genetic History of Siberian and Northeastern European Populations
Emily HM Wong, Andrey Khrunin, Larissa Nichols, Dmitry Pushkarev, Denis Khokhrin, Dmitry Verbenko, Oleg Evgrafov, James Knowles, John Novembre, Svetlana Limborska, Anton Valouev
bioRxiv 029421; doi: https://doi.org/10.1101/029421

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