New Results
Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism
View ORCID ProfileAysu Okbay, View ORCID ProfileBart M.L. Baselmans, View ORCID ProfileJan-Emmanuel De Neve, View ORCID ProfilePatrick Turley, View ORCID ProfileMichel G. Nivard, View ORCID ProfileMark A. Fontana, View ORCID ProfileS. Fleur W. Meddens, View ORCID ProfileRichard Karlsson Linnér, View ORCID ProfileCornelius A. Rietveld, View ORCID ProfileJaime Derringer, View ORCID ProfileJacob Gratten, View ORCID ProfileJames J. Lee, View ORCID ProfileJimmy Z. Liu, View ORCID ProfileRonald de Vlaming, Tarunveer S. Ahluwalia, Jadwiga Buchwald, Alana Cavadino, Alexis C. Frazier-Wood, Nicholas A. Furlotte, Victoria Garfield, Marie Henrike Geisel, Juan R. Gonzalez, Saskia Haitjema, Robert Karlsson, Sander W. van der Laan, Karl-Heinz Ladwig, Jari Lahti, Sven J. van der Lee, Penelope A. Lind, Tian Liu, Lindsay Matteson, Evelin Mihailov, Michael B. Miller, Camelia C. Minica, Ilja M. Nolte, Dennis Mook-Kanamori, Peter J. van der Most, Christopher Oldmeadow, Yong Qian, Olli Raitakari, Rajesh Rawal, Anu Realo, Rico Rueedi, Börge Schmidt, View ORCID ProfileAlbert V. Smith, Evie Stergiakouli, Toshiko Tanaka, Kent Taylor, Juho Wedenoja, Juergen Wellmann, Harm-Jan Westra, Sara M. Willems, Wei Zhao, Behrooz Z. Alizadeh, View ORCID ProfileNajaf Amin, Andrew Bakshi, Patricia A. Boyle, Simon Cox, Gail Davies, Oliver S.P. Davis, Jun Ding, Nese Direk, Peter Eibich, Rebecca T. Emeny, Ghazaleh Fatemifar, Jessica D. Faul, Luigi Ferrucci, Andreas J. Forstner, Christian Gieger, Tamara B. Harris, Juliette M. Harris, Elizabeth G. Holliday, Jouke-Jan Hottenga, Philip L. De Jager, Marika A. Kaakinen, Eero Kajantie, Ville Karhunen, Ivana Kolcic, Meena Kumari, Lenore J. Launer, LifeLines Cohort Study, Ruifang Li-Gao, Marisa Loitfelder, Anu Loukola, Pedro Marques-Vidal, Grant W. Montgomery, Lavinia Paternoster, Alison Pattie, Katja E. Petrovic, Laura Pulkki-Råback, Lydia Quaye, Katri Räikkönen, Igor Rudan, Rodney J. Scott, Jennifer A. Smith, Angelina R. Sutin, Maciej Trzaskowski, Anna E. Vinkhuyzen, Lei Yu, Delilah Zabaneh, John R. Attia, David A. Bennett, Klaus Berger, Lars Bertram, Dorret I. Boomsma, Ute Bultmann, Shun-Chiao Chang, Francesco Cucca, Ian J. Deary, Cornelia M. van Duijn, Johan G. Eriksson, Lude Franke, Eco J.C. de Geus, Patrick J.F. Groenen, Vilmundur Gudnason, Torben Hansen, Catharine A. Hartman, Claire M.A. Haworth, Caroline Hayward, Andrew C. Heath, David A. Hinds, Elina Hyppönen, William G. Iacono, Marjo-Riitta Järvelin, Karl-Heinz Jöckel, Jaakko Kaprio, Sharon L.R. Kardia, Liisa Keltikangas-Järvinen, Peter Kraft, Laura Kubzansky, Terho Lehtimäki, Patrik K.E. Magnusson, Nicholas G. Martin, Matt McGue, Andres Metspalu, Melinda Mills, Renée de Mutsert, Albertine J. Oldehinkel, Gerard Pasterkamp, Nancy L. Pedersen, Robert Plomin, Ozren Polasek, Christine Power, Stephen S. Rich, Frits R. Rosendaal, Hester M. den Ruijter, David Schlessinger, Helena Schmidt, Rauli Svento, Reinhold Schmidt, Harold Snieder, Thorkild I.A. Sørensen, Tim D. Spector, Andrew Steptoe, Antonio Terracciano, A. Roy Thurik, Nicholas J. Timpson, Henning Tiemeier, André G. Uitterlinden, Peter Vollenweider, Gert Wagner, David R. Weir, Jian Yang, View ORCID ProfileDalton C. Conley, George Davey Smith, View ORCID ProfileAlbert Hofman, View ORCID ProfileMagnus Johannesson, View ORCID ProfileDavid I. Laibson, View ORCID ProfileSarah E. Medland, View ORCID ProfileMichelle N. Meyer, View ORCID ProfileJoseph K. Pickrell, View ORCID ProfileTõnu Esko, View ORCID ProfileRobert F. Krueger, View ORCID ProfileJonathan P. Beauchamp, View ORCID ProfilePhilipp D. Koellinger, Daniel J. Benjamin, View ORCID ProfileMeike Bartels, View ORCID ProfileDavid Cesarini
doi: https://doi.org/10.1101/032789
Aysu Okbay
1Department of Applied Economics, Erasmus School of Economics, Erasmus University Rotterdam, 3062 PA, Rotterdam, The Netherlands
2Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
3Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, 3062 PA, The Netherlands
Bart M.L. Baselmans
4Department of Biological Psychology, Vrije Universiteit, Amsterdam, 1081 BT, The Netherlands
5EMGO+ Institute for Health and Care Research, Amsterdam, 1081 BT, The Netherlands
Jan-Emmanuel De Neve
6Saïd Business School, University of Oxford, Oxford, OX1 1HP, UK
Patrick Turley
7Department of Economics, Harvard University, Cambridge, MA 02138, USA
Michel G. Nivard
4Department of Biological Psychology, Vrije Universiteit, Amsterdam, 1081 BT, The Netherlands
Mark A. Fontana
8Department of Economics, University of Michigan, Ann Arbor, MI 48109–1220, USA
S. Fleur W. Meddens
9Department of Complex Trait Genetics, VU University, Center for Neurogenomics and Cognitive Research, Amsterdam, 1081 HV, The Netherlands
3Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, 3062 PA, The Netherlands
10Amsterdam Business School, University of Amsterdam, Amsterdam, 1018 TV, The Netherlands
Richard Karlsson Linnér
9Department of Complex Trait Genetics, VU University, Center for Neurogenomics and Cognitive Research, Amsterdam, 1081 HV, The Netherlands
3Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, 3062 PA, The Netherlands
10Amsterdam Business School, University of Amsterdam, Amsterdam, 1018 TV, The Netherlands
Cornelius A. Rietveld
1Department of Applied Economics, Erasmus School of Economics, Erasmus University Rotterdam, 3062 PA, Rotterdam, The Netherlands
2Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
3Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, 3062 PA, The Netherlands
Jaime Derringer
11Psychology, University of Illinois, IL 61820, Champaign, USA
Jacob Gratten
127Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072 Australia
James J. Lee
12Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN 55455, USA
Jimmy Z. Liu
133New York Genome Center, New York, NY 10013, USA
Ronald de Vlaming
1Department of Applied Economics, Erasmus School of Economics, Erasmus University Rotterdam, 3062 PA, Rotterdam, The Netherlands
2Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
3Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, 3062 PA, The Netherlands
Tarunveer S. Ahluwalia
13COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, 2820 Denmark
14The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, 2100 Denmark
15Steno Diabetes Center, Gentofte, 2820 Denmark
Jadwiga Buchwald
16Department of Public Health, University of Helsinki, Helsinki, FI-00014 Finland
Alana Cavadino
17Centre for Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London EC1M 6BQ, UK
97Population, Policy and Practice, UCL Institute of Child Health, London, WC1N 1EH, UK
Alexis C. Frazier-Wood
18USDA/ARS Children’s Nutrition Research Center, Baylor College of Medicine, Houston, TX 77030, USA
Nicholas A. Furlotte
1923andMe, Inc., Mountain View, CA 94041, USA
Victoria Garfield
120Department of Epidemiology & Public Health, University College London, London WC1E 7HB, UK
Marie Henrike Geisel
44Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Essen, 45147 Germany
Juan R. Gonzalez
20Centre for Research in Environmental Epidemiology, Institute for Global Health, Barcelona Spain
21Universitat Pompeu Fabra, Barcelona Spain
22CIBER Epidemiología y Salud Pública, Barcelona Spain
Saskia Haitjema
111Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands
Robert Karlsson
23Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, 171 77 Sweden
Sander W. van der Laan
111Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands
Karl-Heinz Ladwig
24Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764 Germany
Jari Lahti
25IBS, Unit of Personality, Work and Health, Institute of Behavioural Sciences, P.O. Box 9, 00014 University of Helsinki Finland
26Folkhälsan Research Centre, Helsingfors, FI-00014 Finland
77Helsinki Collegium for Advanced Studies, University of Helsinki, Helsinki 00014 Finland
Sven J. van der Lee
2Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
Penelope A. Lind
27Quantitative Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029 Australia
Tian Liu
28Lifespan Psychology, Max Planck Institute for Human Development, Berlin, 14195 Germany
29Max Planck Institute for Molecular Genetics, Department of Vertebrate Genomics, Berlin, 14195 Germany
Lindsay Matteson
12Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN 55455, USA
Evelin Mihailov
30Estonian Genome Center, University of Tartu, Tartu, 51010 Estonia
Michael B. Miller
12Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN 55455, USA
Camelia C. Minica
4Department of Biological Psychology, Vrije Universiteit, Amsterdam, 1081 BT, The Netherlands
Ilja M. Nolte
34Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands
Dennis Mook-Kanamori
31Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands
32Public Health and Primary Care, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands
33BESC, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia
Peter J. van der Most
34Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands
Christopher Oldmeadow
35Public Health Stream, Hunter Medical Research Institute, New Lambton, NSW 2305 Australia
36Faculty of Health and Medicine, University of Newcastle, Newcastle, NSW 2300 Australia
Yong Qian
37Laboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA
Olli Raitakari
38Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, 20521 Finland
39Department of Clinical Physiology, Turku University Hospital, Turku 20520 Finland
Rajesh Rawal
40Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764 Germany
Anu Realo
41Department of Psychology, University of Tartu, Tartu 50409 Estonia
Rico Rueedi
42Department of Medical Genetics, University of Lausanne, Lausanne, 1005 Switzerland
43Swiss Institute of Bioinformatics, Lausanne, 1015 Switzerland
Börge Schmidt
44Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Essen, 45147 Germany
Albert V. Smith
45Icelandic Heart Association, Kopavogur, 201 Iceland
46Faculty of Medicine, University of Iceland, Reykjavik, 101 Iceland
Evie Stergiakouli
47MRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK
Toshiko Tanaka
60National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Kent Taylor
48Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA, Torrence, 90505 CA, USA
Juho Wedenoja
16Department of Public Health, University of Helsinki, Helsinki, FI-00014 Finland
Juergen Wellmann
49Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, 48149 Germany
Harm-Jan Westra
50Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
Sara M. Willems
2Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
Wei Zhao
51Department of Epidemiology, University of Michigan, Ann Arbor, MI 48104, USA
Behrooz Z. Alizadeh
34Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands
52Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, The Netherlands
Najaf Amin
2Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
Andrew Bakshi
127Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072 Australia
Patricia A. Boyle
53Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Simon Cox
54Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK
55Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK
Gail Davies
54Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK
55Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK
Oliver S.P. Davis
47MRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK
Jun Ding
37Laboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA
Nese Direk
2Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
Peter Eibich
56German Socio-Economic Panel Study, DIW Berlin, Berlin, 10117 Germany
57Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK
Rebecca T. Emeny
24Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764 Germany
Ghazaleh Fatemifar
58The Farr Institute of Health Informatics, University College London, London NW1 2DA, UK
Jessica D. Faul
59Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI 48104, USA
Luigi Ferrucci
60National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Andreas J. Forstner
61Institute of Human Genetics, University of Bonn, Bonn, 53127 Germany
62Department of Genomics, Life and Brain Center, University of Bonn, Bonn, 53127 Germany
Christian Gieger
40Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764 Germany
Tamara B. Harris
63Laboratory of Epidemiology, Demography, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892–9205, United States
Juliette M. Harris
78Department of Twin Research and Genetic Epidemiology, King’s College London, London, SE1 7EH, UK
Elizabeth G. Holliday
35Public Health Stream, Hunter Medical Research Institute, New Lambton, NSW 2305 Australia
36Faculty of Health and Medicine, University of Newcastle, Newcastle, NSW 2300 Australia
Jouke-Jan Hottenga
4Department of Biological Psychology, Vrije Universiteit, Amsterdam, 1081 BT, The Netherlands
5EMGO+ Institute for Health and Care Research, Amsterdam, 1081 BT, The Netherlands
Philip L. De Jager
64Program in Translational NeuroPsychiatric Genomics, Departments of Neurology & Psychiatry, Brigham and Women’s Hospital, Boston, MA 02115, USA
65Harvard Medical School, Boston, MA 02115, USA
66Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, 02142, USA
Marika A. Kaakinen
67Department of Genomics of Common Disease, Imperial College London, London, W12 0NN, UK
70Center for Life Course Health Research, University of Oulu; Oulu University Hospital, Oulu Finland
Eero Kajantie
68Department of Pediatrics, University of Helsinki, Helsinki Finland
69National Institute for Health and Welfare, Helsinki Finland
Ville Karhunen
70Center for Life Course Health Research, University of Oulu; Oulu University Hospital, Oulu Finland
Ivana Kolcic
114Department of Public Health, Faculty of Medicine, University of Split, Croatia, Split 21000 Croatia
Meena Kumari
71Institute for Social & Economic Research, University of Essex, Wivenhoe Park CO4 3SQ, UK
Lenore J. Launer
72Neuroepidemiology Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892-9205, USA
LifeLines Cohort Study
73LifeLines Cohort Study, University of Groningen, University Medical Center Groningen, Groningen, 9713 BZ, The Netherlands
Ruifang Li-Gao
31Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands
Marisa Loitfelder
117Department of Neurology, General Hospital and Medical University Graz, Graz, 8036 Austria
Anu Loukola
16Department of Public Health, University of Helsinki, Helsinki, FI-00014 Finland
Pedro Marques-Vidal
74Department of Internal Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, 1011 Switzerland
Grant W. Montgomery
75Molecular Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029 Australia
Lavinia Paternoster
47MRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK
Alison Pattie
55Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK
Katja E. Petrovic
76Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK
Laura Pulkki-Råback
25IBS, Unit of Personality, Work and Health, Institute of Behavioural Sciences, P.O. Box 9, 00014 University of Helsinki Finland
77Helsinki Collegium for Advanced Studies, University of Helsinki, Helsinki 00014 Finland
Lydia Quaye
78Department of Twin Research and Genetic Epidemiology, King’s College London, London, SE1 7EH, UK
Katri Räikkönen
25IBS, Unit of Personality, Work and Health, Institute of Behavioural Sciences, P.O. Box 9, 00014 University of Helsinki Finland
Igor Rudan
79Centre for Global Health Research, The Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK
Rodney J. Scott
80Information Based Medicine Stream, Hunter Medical Research Institute, New Lambton, NSW 2305 Australia
36Faculty of Health and Medicine, University of Newcastle, Newcastle, NSW 2300 Australia
Jennifer A. Smith
51Department of Epidemiology, University of Michigan, Ann Arbor, MI 48104, USA
Angelina R. Sutin
121Department of Geriatrics, Florida State University College of Medicine, Tallahassee, FL 32306, USA
60National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Maciej Trzaskowski
113Social, Genetic and Developmental Psychiatry Centre, King’s College London, De Crespigny Park SE5 8AF, UK
127Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072 Australia
Anna E. Vinkhuyzen
127Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072 Australia
Lei Yu
81Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Delilah Zabaneh
113Social, Genetic and Developmental Psychiatry Centre, King’s College London, De Crespigny Park SE5 8AF, UK
John R. Attia
35Public Health Stream, Hunter Medical Research Institute, New Lambton, NSW 2305 Australia
36Faculty of Health and Medicine, University of Newcastle, Newcastle, NSW 2300 Australia
David A. Bennett
81Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Klaus Berger
49Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, 48149 Germany
Lars Bertram
82Lübeck Interdisciplinary platform for Genome Analytics (LIGA), Institutes of Neurogenetics and Integrative & Experimental Genomics, University of Lübeck, Lübeck, 23562 Germany
83Neuroepidemiology and Ageing Research Unit, School of Public Health, Faculty of Medicine, Imperial College, London SW7 2AZ, UK
Dorret I. Boomsma
4Department of Biological Psychology, Vrije Universiteit, Amsterdam, 1081 BT, The Netherlands
5EMGO+ Institute for Health and Care Research, Amsterdam, 1081 BT, The Netherlands
136Neuroscience Campus Amsterdam, Amsterdam, The Netherlands
Ute Bultmann
84Department of Health Sciences, Community & Occupational Medicine, University of Groningen, University Medical Center Groningen, Groningen, 9713 AV, The Netherlands
Shun-Chiao Chang
85Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA
Francesco Cucca
86Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari, 9042 Italy
Ian J. Deary
54Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK
55Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK
Cornelia M. van Duijn
2Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
Johan G. Eriksson
87Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, 00014 Finland
88Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki Finland
89Unit of General Practice, University Central Hospital, Helsinki Finland
Lude Franke
90Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen. 9700 RB, The Netherlands
Eco J.C. de Geus
4Department of Biological Psychology, Vrije Universiteit, Amsterdam, 1081 BT, The Netherlands
5EMGO+ Institute for Health and Care Research, Amsterdam, 1081 BT, The Netherlands
136Neuroscience Campus Amsterdam, Amsterdam, The Netherlands
Patrick J.F. Groenen
3Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, 3062 PA, The Netherlands
91Econometric Institute, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, 3062 PA, The Netherlands
Vilmundur Gudnason
45Icelandic Heart Association, Kopavogur, 201 Iceland
46Faculty of Medicine, University of Iceland, Reykjavik, 101 Iceland
Torben Hansen
14The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, 2100 Denmark
Catharine A. Hartman
110Department of Psychiatry, University of Groningen, University Medical Center Groningen, 9700 RB, Groningen, The Netherlands
Claire M.A. Haworth
47MRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK
Caroline Hayward
92MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK
93Generation Scotland, Centre for Genomics and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK
Andrew C. Heath
94Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA
David A. Hinds
1923andMe, Inc., Mountain View, CA 94041, USA
Elina Hyppönen
95Centre for Population Health Research, School of Health Sciences and Sansom Institute, University of South Australia, SA5000, Adelaide Australia
96South Australian Health and Medical Research Institute, Adelaide, SA5000 Australia
97Population, Policy and Practice, UCL Institute of Child Health, London, WC1N 1EH, UK
William G. Iacono
12Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN 55455, USA
Marjo-Riitta Järvelin
98Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPE) Centre for Environment and Health, School of Public Health, Imperial College London, UK
99Biocenter Oulu, University of Oulu, Oulu Finland
70Center for Life Course Health Research, University of Oulu; Oulu University Hospital, Oulu Finland
100Unit of Primary Care, Oulu University Hospital, Oulu Finland
Karl-Heinz Jöckel
44Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Essen, 45147 Germany
Jaakko Kaprio
16Department of Public Health, University of Helsinki, Helsinki, FI-00014 Finland
101Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, 00014 Finland
102Department for Health, THL-National Institute for Health and Welfare, Helsinki, FI-00271 Finland
Sharon L.R. Kardia
51Department of Epidemiology, University of Michigan, Ann Arbor, MI 48104, USA
Liisa Keltikangas-Järvinen
25IBS, Unit of Personality, Work and Health, Institute of Behavioural Sciences, P.O. Box 9, 00014 University of Helsinki Finland
Peter Kraft
103Department of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA
Laura Kubzansky
104Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA
Terho Lehtimäki
105Fimlab Laboratories, Tampere, 33520 Finland
106Department of Clinical Chemistry, University of Tampere, School of Medicine, Tampere, 33014 Finland
Patrik K.E. Magnusson
23Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, 171 77 Sweden
Nicholas G. Martin
107Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029 Australia
Matt McGue
12Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN 55455, USA
Andres Metspalu
30Estonian Genome Center, University of Tartu, Tartu, 51010 Estonia
108Institute of Molecular and Cell Biology, University of Tartu, Tartu, 51010 Estonia
Melinda Mills
109Department of Sociology, University of Oxford, Oxford OX1 3UQ, UK
Renée de Mutsert
31Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands
Albertine J. Oldehinkel
110Department of Psychiatry, University of Groningen, University Medical Center Groningen, 9700 RB, Groningen, The Netherlands
Gerard Pasterkamp
111Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands
112Laboratory of Clinical Chemistry and Hematology, Division Laboratories and Pharmacy, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands
Nancy L. Pedersen
23Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, 171 77 Sweden
Robert Plomin
113Social, Genetic and Developmental Psychiatry Centre, King’s College London, De Crespigny Park SE5 8AF, UK
Ozren Polasek
114Department of Public Health, Faculty of Medicine, University of Split, Croatia, Split 21000 Croatia
Christine Power
97Population, Policy and Practice, UCL Institute of Child Health, London, WC1N 1EH, UK
Stephen S. Rich
115Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22904, USA
Frits R. Rosendaal
31Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands
Hester M. den Ruijter
111Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands
David Schlessinger
37Laboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA
Helena Schmidt
116Research Unit for Genetic Epidemiology, Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, General Hospital and Medical University, Graz, Graz, 8010 Austria
117Department of Neurology, General Hospital and Medical University Graz, Graz, 8036 Austria
Rauli Svento
118Department of Economics, Oulu Business School, Oulu Finland
Reinhold Schmidt
117Department of Neurology, General Hospital and Medical University Graz, Graz, 8036 Austria
Harold Snieder
34Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands
Thorkild I.A. Sørensen
14The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, 2100 Denmark
47MRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK
119Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, The Capital Region, Frederiksberg, 2000 Denmark
Tim D. Spector
78Department of Twin Research and Genetic Epidemiology, King’s College London, London, SE1 7EH, UK
Andrew Steptoe
120Department of Epidemiology & Public Health, University College London, London WC1E 7HB, UK
Antonio Terracciano
121Department of Geriatrics, Florida State University College of Medicine, Tallahassee, FL 32306, USA
60National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
A. Roy Thurik
1Department of Applied Economics, Erasmus School of Economics, Erasmus University Rotterdam, 3062 PA, Rotterdam, The Netherlands
3Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, 3062 PA, The Netherlands
122Montpellier Business School, Montpellier, 34080 France
123Panteia, Zoetermeer, 2715 CA, The Netherlands
Nicholas J. Timpson
47MRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK
Henning Tiemeier
2Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
124Department of Psychiatry, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
125Department of Child and Adolescent Psychiatry, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
André G. Uitterlinden
2Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
3Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, 3062 PA, The Netherlands
126Department of Internal Medicine, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
Peter Vollenweider
74Department of Internal Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, 1011 Switzerland
Gert Wagner
56German Socio-Economic Panel Study, DIW Berlin, Berlin, 10117 Germany
David R. Weir
59Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI 48104, USA
Jian Yang
127Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072 Australia
128The University of Queensland Diamantina Institute, The Translation Research Institute, Brisbane, QLD 4102 Australia
Dalton C. Conley
129Department of Sociology, New York University, New York, NY 10012, USA
130School of Medicine, New York University, NY 10016, New York, USA
George Davey Smith
47MRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK
Albert Hofman
2Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
Magnus Johannesson
131Department of Economics, Stockholm School of Economics, Stockholm, 113 83 Sweden
David I. Laibson
7Department of Economics, Harvard University, Cambridge, MA 02138, USA
Sarah E. Medland
27Quantitative Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029 Australia
Michelle N. Meyer
132Bioethics Program, Union Graduate College - Icahn School of Medicine at Mount Sinai, Schenectady, NY 12308, USA
Joseph K. Pickrell
133New York Genome Center, New York, NY 10013, USA
134Department of Biological Sciences, Columbia University, 600 Fairchild Center, New York, NY 10027, USA
Tõnu Esko
30Estonian Genome Center, University of Tartu, Tartu, 51010 Estonia
Robert F. Krueger
12Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN 55455, USA
Jonathan P. Beauchamp
7Department of Economics, Harvard University, Cambridge, MA 02138, USA
Philipp D. Koellinger
9Department of Complex Trait Genetics, VU University, Center for Neurogenomics and Cognitive Research, Amsterdam, 1081 HV, The Netherlands
3Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, 3062 PA, The Netherlands
10Amsterdam Business School, University of Amsterdam, Amsterdam, 1018 TV, The Netherlands
Daniel J. Benjamin
135Center for Economic and Social Research, University of Southern California, Los Angeles, CA 90089-3332, USA
Meike Bartels
4Department of Biological Psychology, Vrije Universiteit, Amsterdam, 1081 BT, The Netherlands
5EMGO+ Institute for Health and Care Research, Amsterdam, 1081 BT, The Netherlands
136Neuroscience Campus Amsterdam, Amsterdam, The Netherlands
David Cesarini
137Department of Economics, New York University, New York, NY 10012, USA
138Research Institute for Industrial Economics, Stockholm, 10215 Sweden
Summary
We conducted a genome-wide association study of subjective well-being (SWB) in 298,420 individuals. We also performed auxiliary analyses of depressive symptoms (“DS”; N = 161,460) and neuroticism (N = 170,910), both of which have a substantial genetic correlation with SWB 
. We identify three SNPs associated with SWB at genome-wide significance. Two of them are significantly associated with DS in an independent sample. In our auxiliary analyses, we identify 13 additional genome-wide-significant associations: two with DS and eleven with neuroticism, including two inversion polymorphisms. Across our phenotypes, loci regulating expression in central nervous system and adrenal/pancreas tissues are enriched. The discovery of genetic loci associated with the three phenotypes we study has proven elusive; our findings illustrate the payoffs from studying them jointly.
One Sentence Summary: Using both genome-wide association studies and proxy-phenotype studies, we identify genetic variants associated with subjective well-being, depressive symptoms, and neuroticism.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Posted November 24, 2015.
Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism
Aysu Okbay, Bart M.L. Baselmans, Jan-Emmanuel De Neve, Patrick Turley, Michel G. Nivard, Mark A. Fontana, S. Fleur W. Meddens, Richard Karlsson Linnér, Cornelius A. Rietveld, Jaime Derringer, Jacob Gratten, James J. Lee, Jimmy Z. Liu, Ronald de Vlaming, Tarunveer S. Ahluwalia, Jadwiga Buchwald, Alana Cavadino, Alexis C. Frazier-Wood, Nicholas A. Furlotte, Victoria Garfield, Marie Henrike Geisel, Juan R. Gonzalez, Saskia Haitjema, Robert Karlsson, Sander W. van der Laan, Karl-Heinz Ladwig, Jari Lahti, Sven J. van der Lee, Penelope A. Lind, Tian Liu, Lindsay Matteson, Evelin Mihailov, Michael B. Miller, Camelia C. Minica, Ilja M. Nolte, Dennis Mook-Kanamori, Peter J. van der Most, Christopher Oldmeadow, Yong Qian, Olli Raitakari, Rajesh Rawal, Anu Realo, Rico Rueedi, Börge Schmidt, Albert V. Smith, Evie Stergiakouli, Toshiko Tanaka, Kent Taylor, Juho Wedenoja, Juergen Wellmann, Harm-Jan Westra, Sara M. Willems, Wei Zhao, Behrooz Z. Alizadeh, Najaf Amin, Andrew Bakshi, Patricia A. Boyle, Simon Cox, Gail Davies, Oliver S.P. Davis, Jun Ding, Nese Direk, Peter Eibich, Rebecca T. Emeny, Ghazaleh Fatemifar, Jessica D. Faul, Luigi Ferrucci, Andreas J. Forstner, Christian Gieger, Tamara B. Harris, Juliette M. Harris, Elizabeth G. Holliday, Jouke-Jan Hottenga, Philip L. De Jager, Marika A. Kaakinen, Eero Kajantie, Ville Karhunen, Ivana Kolcic, Meena Kumari, Lenore J. Launer, LifeLines Cohort Study, Ruifang Li-Gao, Marisa Loitfelder, Anu Loukola, Pedro Marques-Vidal, Grant W. Montgomery, Lavinia Paternoster, Alison Pattie, Katja E. Petrovic, Laura Pulkki-Råback, Lydia Quaye, Katri Räikkönen, Igor Rudan, Rodney J. Scott, Jennifer A. Smith, Angelina R. Sutin, Maciej Trzaskowski, Anna E. Vinkhuyzen, Lei Yu, Delilah Zabaneh, John R. Attia, David A. Bennett, Klaus Berger, Lars Bertram, Dorret I. Boomsma, Ute Bultmann, Shun-Chiao Chang, Francesco Cucca, Ian J. Deary, Cornelia M. van Duijn, Johan G. Eriksson, Lude Franke, Eco J.C. de Geus, Patrick J.F. Groenen, Vilmundur Gudnason, Torben Hansen, Catharine A. Hartman, Claire M.A. Haworth, Caroline Hayward, Andrew C. Heath, David A. Hinds, Elina Hyppönen, William G. Iacono, Marjo-Riitta Järvelin, Karl-Heinz Jöckel, Jaakko Kaprio, Sharon L.R. Kardia, Liisa Keltikangas-Järvinen, Peter Kraft, Laura Kubzansky, Terho Lehtimäki, Patrik K.E. Magnusson, Nicholas G. Martin, Matt McGue, Andres Metspalu, Melinda Mills, Renée de Mutsert, Albertine J. Oldehinkel, Gerard Pasterkamp, Nancy L. Pedersen, Robert Plomin, Ozren Polasek, Christine Power, Stephen S. Rich, Frits R. Rosendaal, Hester M. den Ruijter, David Schlessinger, Helena Schmidt, Rauli Svento, Reinhold Schmidt, Harold Snieder, Thorkild I.A. Sørensen, Tim D. Spector, Andrew Steptoe, Antonio Terracciano, A. Roy Thurik, Nicholas J. Timpson, Henning Tiemeier, André G. Uitterlinden, Peter Vollenweider, Gert Wagner, David R. Weir, Jian Yang, Dalton C. Conley, George Davey Smith, Albert Hofman, Magnus Johannesson, David I. Laibson, Sarah E. Medland, Michelle N. Meyer, Joseph K. Pickrell, Tõnu Esko, Robert F. Krueger, Jonathan P. Beauchamp, Philipp D. Koellinger, Daniel J. Benjamin, Meike Bartels, David Cesarini
bioRxiv 032789; doi: https://doi.org/10.1101/032789
Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism
Aysu Okbay, Bart M.L. Baselmans, Jan-Emmanuel De Neve, Patrick Turley, Michel G. Nivard, Mark A. Fontana, S. Fleur W. Meddens, Richard Karlsson Linnér, Cornelius A. Rietveld, Jaime Derringer, Jacob Gratten, James J. Lee, Jimmy Z. Liu, Ronald de Vlaming, Tarunveer S. Ahluwalia, Jadwiga Buchwald, Alana Cavadino, Alexis C. Frazier-Wood, Nicholas A. Furlotte, Victoria Garfield, Marie Henrike Geisel, Juan R. Gonzalez, Saskia Haitjema, Robert Karlsson, Sander W. van der Laan, Karl-Heinz Ladwig, Jari Lahti, Sven J. van der Lee, Penelope A. Lind, Tian Liu, Lindsay Matteson, Evelin Mihailov, Michael B. Miller, Camelia C. Minica, Ilja M. Nolte, Dennis Mook-Kanamori, Peter J. van der Most, Christopher Oldmeadow, Yong Qian, Olli Raitakari, Rajesh Rawal, Anu Realo, Rico Rueedi, Börge Schmidt, Albert V. Smith, Evie Stergiakouli, Toshiko Tanaka, Kent Taylor, Juho Wedenoja, Juergen Wellmann, Harm-Jan Westra, Sara M. Willems, Wei Zhao, Behrooz Z. Alizadeh, Najaf Amin, Andrew Bakshi, Patricia A. Boyle, Simon Cox, Gail Davies, Oliver S.P. Davis, Jun Ding, Nese Direk, Peter Eibich, Rebecca T. Emeny, Ghazaleh Fatemifar, Jessica D. Faul, Luigi Ferrucci, Andreas J. Forstner, Christian Gieger, Tamara B. Harris, Juliette M. Harris, Elizabeth G. Holliday, Jouke-Jan Hottenga, Philip L. De Jager, Marika A. Kaakinen, Eero Kajantie, Ville Karhunen, Ivana Kolcic, Meena Kumari, Lenore J. Launer, LifeLines Cohort Study, Ruifang Li-Gao, Marisa Loitfelder, Anu Loukola, Pedro Marques-Vidal, Grant W. Montgomery, Lavinia Paternoster, Alison Pattie, Katja E. Petrovic, Laura Pulkki-Råback, Lydia Quaye, Katri Räikkönen, Igor Rudan, Rodney J. Scott, Jennifer A. Smith, Angelina R. Sutin, Maciej Trzaskowski, Anna E. Vinkhuyzen, Lei Yu, Delilah Zabaneh, John R. Attia, David A. Bennett, Klaus Berger, Lars Bertram, Dorret I. Boomsma, Ute Bultmann, Shun-Chiao Chang, Francesco Cucca, Ian J. Deary, Cornelia M. van Duijn, Johan G. Eriksson, Lude Franke, Eco J.C. de Geus, Patrick J.F. Groenen, Vilmundur Gudnason, Torben Hansen, Catharine A. Hartman, Claire M.A. Haworth, Caroline Hayward, Andrew C. Heath, David A. Hinds, Elina Hyppönen, William G. Iacono, Marjo-Riitta Järvelin, Karl-Heinz Jöckel, Jaakko Kaprio, Sharon L.R. Kardia, Liisa Keltikangas-Järvinen, Peter Kraft, Laura Kubzansky, Terho Lehtimäki, Patrik K.E. Magnusson, Nicholas G. Martin, Matt McGue, Andres Metspalu, Melinda Mills, Renée de Mutsert, Albertine J. Oldehinkel, Gerard Pasterkamp, Nancy L. Pedersen, Robert Plomin, Ozren Polasek, Christine Power, Stephen S. Rich, Frits R. Rosendaal, Hester M. den Ruijter, David Schlessinger, Helena Schmidt, Rauli Svento, Reinhold Schmidt, Harold Snieder, Thorkild I.A. Sørensen, Tim D. Spector, Andrew Steptoe, Antonio Terracciano, A. Roy Thurik, Nicholas J. Timpson, Henning Tiemeier, André G. Uitterlinden, Peter Vollenweider, Gert Wagner, David R. Weir, Jian Yang, Dalton C. Conley, George Davey Smith, Albert Hofman, Magnus Johannesson, David I. Laibson, Sarah E. Medland, Michelle N. Meyer, Joseph K. Pickrell, Tõnu Esko, Robert F. Krueger, Jonathan P. Beauchamp, Philipp D. Koellinger, Daniel J. Benjamin, Meike Bartels, David Cesarini
bioRxiv 032789; doi: https://doi.org/10.1101/032789
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