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Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

View ORCID ProfileAysu Okbay, View ORCID ProfileBart M.L. Baselmans, View ORCID ProfileJan-Emmanuel De Neve, View ORCID ProfilePatrick Turley, View ORCID ProfileMichel G. Nivard, View ORCID ProfileMark A. Fontana, View ORCID ProfileS. Fleur W. Meddens, View ORCID ProfileRichard Karlsson Linnér, View ORCID ProfileCornelius A. Rietveld, View ORCID ProfileJaime Derringer, View ORCID ProfileJacob Gratten, View ORCID ProfileJames J. Lee, View ORCID ProfileJimmy Z. Liu, View ORCID ProfileRonald de Vlaming, Tarunveer S. Ahluwalia, Jadwiga Buchwald, Alana Cavadino, Alexis C. Frazier-Wood, Nicholas A. Furlotte, Victoria Garfield, Marie Henrike Geisel, Juan R. Gonzalez, Saskia Haitjema, Robert Karlsson, Sander W. van der Laan, Karl-Heinz Ladwig, Jari Lahti, Sven J. van der Lee, Penelope A. Lind, Tian Liu, Lindsay Matteson, Evelin Mihailov, Michael B. Miller, Camelia C. Minica, Ilja M. Nolte, Dennis Mook-Kanamori, Peter J. van der Most, Christopher Oldmeadow, Yong Qian, Olli Raitakari, Rajesh Rawal, Anu Realo, Rico Rueedi, Börge Schmidt, View ORCID ProfileAlbert V. Smith, Evie Stergiakouli, Toshiko Tanaka, Kent Taylor, Juho Wedenoja, Juergen Wellmann, Harm-Jan Westra, Sara M. Willems, Wei Zhao, Behrooz Z. Alizadeh, View ORCID ProfileNajaf Amin, Andrew Bakshi, Patricia A. Boyle, Simon Cox, Gail Davies, Oliver S.P. Davis, Jun Ding, Nese Direk, Peter Eibich, Rebecca T. Emeny, Ghazaleh Fatemifar, Jessica D. Faul, Luigi Ferrucci, Andreas J. Forstner, Christian Gieger, Tamara B. Harris, Juliette M. Harris, Elizabeth G. Holliday, Jouke-Jan Hottenga, Philip L. De Jager, Marika A. Kaakinen, Eero Kajantie, Ville Karhunen, Ivana Kolcic, Meena Kumari, Lenore J. Launer, LifeLines Cohort Study, Ruifang Li-Gao, Marisa Loitfelder, Anu Loukola, Pedro Marques-Vidal, Grant W. Montgomery, Lavinia Paternoster, Alison Pattie, Katja E. Petrovic, Laura Pulkki-Råback, Lydia Quaye, Katri Räikkönen, Igor Rudan, Rodney J. Scott, Jennifer A. Smith, Angelina R. Sutin, Maciej Trzaskowski, Anna E. Vinkhuyzen, Lei Yu, Delilah Zabaneh, John R. Attia, David A. Bennett, Klaus Berger, Lars Bertram, Dorret I. Boomsma, Ute Bultmann, Shun-Chiao Chang, Francesco Cucca, Ian J. Deary, Cornelia M. van Duijn, Johan G. Eriksson, Lude Franke, Eco J.C. de Geus, Patrick J.F. Groenen, Vilmundur Gudnason, Torben Hansen, Catharine A. Hartman, Claire M.A. Haworth, Caroline Hayward, Andrew C. Heath, David A. Hinds, Elina Hyppönen, William G. Iacono, Marjo-Riitta Järvelin, Karl-Heinz Jöckel, Jaakko Kaprio, Sharon L.R. Kardia, Liisa Keltikangas-Järvinen, Peter Kraft, Laura Kubzansky, Terho Lehtimäki, Patrik K.E. Magnusson, Nicholas G. Martin, Matt McGue, Andres Metspalu, Melinda Mills, Renée de Mutsert, Albertine J. Oldehinkel, Gerard Pasterkamp, Nancy L. Pedersen, Robert Plomin, Ozren Polasek, Christine Power, Stephen S. Rich, Frits R. Rosendaal, Hester M. den Ruijter, David Schlessinger, Helena Schmidt, Rauli Svento, Reinhold Schmidt, Harold Snieder, Thorkild I.A. Sørensen, Tim D. Spector, Andrew Steptoe, Antonio Terracciano, A. Roy Thurik, Nicholas J. Timpson, Henning Tiemeier, André G. Uitterlinden, Peter Vollenweider, Gert Wagner, David R. Weir, Jian Yang, View ORCID ProfileDalton C. Conley, George Davey Smith, View ORCID ProfileAlbert Hofman, View ORCID ProfileMagnus Johannesson, View ORCID ProfileDavid I. Laibson, View ORCID ProfileSarah E. Medland, View ORCID ProfileMichelle N. Meyer, View ORCID ProfileJoseph K. Pickrell, View ORCID ProfileTõnu Esko, View ORCID ProfileRobert F. Krueger, View ORCID ProfileJonathan P. Beauchamp, View ORCID ProfilePhilipp D. Koellinger, Daniel J. Benjamin, View ORCID ProfileMeike Bartels, View ORCID ProfileDavid Cesarini
doi: https://doi.org/10.1101/032789
Aysu Okbay
1Department of Applied Economics, Erasmus School of Economics, Erasmus University Rotterdam, 3062 PA, Rotterdam, The Netherlands
2Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
3Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, 3062 PA, The Netherlands
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  • ORCID record for Aysu Okbay
  • For correspondence: djbenjam@usc.edu m.bartels@vu.nl p.d.koellinger@vu.nl
Bart M.L. Baselmans
4Department of Biological Psychology, Vrije Universiteit, Amsterdam, 1081 BT, The Netherlands
5EMGO+ Institute for Health and Care Research, Amsterdam, 1081 BT, The Netherlands
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  • For correspondence: djbenjam@usc.edu m.bartels@vu.nl p.d.koellinger@vu.nl
Jan-Emmanuel De Neve
6Saïd Business School, University of Oxford, Oxford, OX1 1HP, UK
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  • For correspondence: djbenjam@usc.edu m.bartels@vu.nl p.d.koellinger@vu.nl
Patrick Turley
7Department of Economics, Harvard University, Cambridge, MA 02138, USA
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  • For correspondence: djbenjam@usc.edu m.bartels@vu.nl p.d.koellinger@vu.nl
Michel G. Nivard
4Department of Biological Psychology, Vrije Universiteit, Amsterdam, 1081 BT, The Netherlands
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  • For correspondence: djbenjam@usc.edu m.bartels@vu.nl p.d.koellinger@vu.nl
Mark A. Fontana
8Department of Economics, University of Michigan, Ann Arbor, MI 48109–1220, USA
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  • For correspondence: djbenjam@usc.edu m.bartels@vu.nl p.d.koellinger@vu.nl
S. Fleur W. Meddens
9Department of Complex Trait Genetics, VU University, Center for Neurogenomics and Cognitive Research, Amsterdam, 1081 HV, The Netherlands
3Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, 3062 PA, The Netherlands
10Amsterdam Business School, University of Amsterdam, Amsterdam, 1018 TV, The Netherlands
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  • For correspondence: djbenjam@usc.edu m.bartels@vu.nl p.d.koellinger@vu.nl
Richard Karlsson Linnér
9Department of Complex Trait Genetics, VU University, Center for Neurogenomics and Cognitive Research, Amsterdam, 1081 HV, The Netherlands
3Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, 3062 PA, The Netherlands
10Amsterdam Business School, University of Amsterdam, Amsterdam, 1018 TV, The Netherlands
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  • For correspondence: djbenjam@usc.edu m.bartels@vu.nl p.d.koellinger@vu.nl
Cornelius A. Rietveld
1Department of Applied Economics, Erasmus School of Economics, Erasmus University Rotterdam, 3062 PA, Rotterdam, The Netherlands
2Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
3Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, 3062 PA, The Netherlands
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  • For correspondence: djbenjam@usc.edu m.bartels@vu.nl p.d.koellinger@vu.nl
Jaime Derringer
11Psychology, University of Illinois, IL 61820, Champaign, USA
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Jacob Gratten
127Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072 Australia
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James J. Lee
12Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN 55455, USA
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Jimmy Z. Liu
133New York Genome Center, New York, NY 10013, USA
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Ronald de Vlaming
1Department of Applied Economics, Erasmus School of Economics, Erasmus University Rotterdam, 3062 PA, Rotterdam, The Netherlands
2Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
3Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, 3062 PA, The Netherlands
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Tarunveer S. Ahluwalia
13COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, 2820 Denmark
14The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, 2100 Denmark
15Steno Diabetes Center, Gentofte, 2820 Denmark
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Jadwiga Buchwald
16Department of Public Health, University of Helsinki, Helsinki, FI-00014 Finland
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Alana Cavadino
17Centre for Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London EC1M 6BQ, UK
97Population, Policy and Practice, UCL Institute of Child Health, London, WC1N 1EH, UK
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Alexis C. Frazier-Wood
18USDA/ARS Children’s Nutrition Research Center, Baylor College of Medicine, Houston, TX 77030, USA
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Nicholas A. Furlotte
1923andMe, Inc., Mountain View, CA 94041, USA
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Victoria Garfield
120Department of Epidemiology & Public Health, University College London, London WC1E 7HB, UK
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Marie Henrike Geisel
44Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Essen, 45147 Germany
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Juan R. Gonzalez
20Centre for Research in Environmental Epidemiology, Institute for Global Health, Barcelona Spain
21Universitat Pompeu Fabra, Barcelona Spain
22CIBER Epidemiología y Salud Pública, Barcelona Spain
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Saskia Haitjema
111Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands
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Robert Karlsson
23Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, 171 77 Sweden
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Sander W. van der Laan
111Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands
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Karl-Heinz Ladwig
24Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764 Germany
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Jari Lahti
25IBS, Unit of Personality, Work and Health, Institute of Behavioural Sciences, P.O. Box 9, 00014 University of Helsinki Finland
26Folkhälsan Research Centre, Helsingfors, FI-00014 Finland
77Helsinki Collegium for Advanced Studies, University of Helsinki, Helsinki 00014 Finland
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Sven J. van der Lee
2Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
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Penelope A. Lind
27Quantitative Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029 Australia
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Tian Liu
28Lifespan Psychology, Max Planck Institute for Human Development, Berlin, 14195 Germany
29Max Planck Institute for Molecular Genetics, Department of Vertebrate Genomics, Berlin, 14195 Germany
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Lindsay Matteson
12Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN 55455, USA
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Evelin Mihailov
30Estonian Genome Center, University of Tartu, Tartu, 51010 Estonia
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Michael B. Miller
12Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN 55455, USA
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Camelia C. Minica
4Department of Biological Psychology, Vrije Universiteit, Amsterdam, 1081 BT, The Netherlands
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Ilja M. Nolte
34Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands
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Dennis Mook-Kanamori
31Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands
32Public Health and Primary Care, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands
33BESC, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia
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Peter J. van der Most
34Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands
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Christopher Oldmeadow
35Public Health Stream, Hunter Medical Research Institute, New Lambton, NSW 2305 Australia
36Faculty of Health and Medicine, University of Newcastle, Newcastle, NSW 2300 Australia
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Yong Qian
37Laboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA
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Olli Raitakari
38Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, 20521 Finland
39Department of Clinical Physiology, Turku University Hospital, Turku 20520 Finland
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Rajesh Rawal
40Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764 Germany
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Anu Realo
41Department of Psychology, University of Tartu, Tartu 50409 Estonia
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Rico Rueedi
42Department of Medical Genetics, University of Lausanne, Lausanne, 1005 Switzerland
43Swiss Institute of Bioinformatics, Lausanne, 1015 Switzerland
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Börge Schmidt
44Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Essen, 45147 Germany
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Albert V. Smith
45Icelandic Heart Association, Kopavogur, 201 Iceland
46Faculty of Medicine, University of Iceland, Reykjavik, 101 Iceland
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Evie Stergiakouli
47MRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK
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Toshiko Tanaka
60National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
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Kent Taylor
48Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA, Torrence, 90505 CA, USA
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Juho Wedenoja
16Department of Public Health, University of Helsinki, Helsinki, FI-00014 Finland
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Juergen Wellmann
49Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, 48149 Germany
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Harm-Jan Westra
50Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
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Sara M. Willems
2Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
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Wei Zhao
51Department of Epidemiology, University of Michigan, Ann Arbor, MI 48104, USA
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Behrooz Z. Alizadeh
34Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands
52Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, The Netherlands
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Najaf Amin
2Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
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Andrew Bakshi
127Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072 Australia
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Patricia A. Boyle
53Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL 60612, USA
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Simon Cox
54Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK
55Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK
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Gail Davies
54Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK
55Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK
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Oliver S.P. Davis
47MRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK
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Jun Ding
37Laboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA
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Nese Direk
2Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
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Peter Eibich
56German Socio-Economic Panel Study, DIW Berlin, Berlin, 10117 Germany
57Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK
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Rebecca T. Emeny
24Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764 Germany
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Ghazaleh Fatemifar
58The Farr Institute of Health Informatics, University College London, London NW1 2DA, UK
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Jessica D. Faul
59Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI 48104, USA
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Luigi Ferrucci
60National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
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Andreas J. Forstner
61Institute of Human Genetics, University of Bonn, Bonn, 53127 Germany
62Department of Genomics, Life and Brain Center, University of Bonn, Bonn, 53127 Germany
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Christian Gieger
40Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764 Germany
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Tamara B. Harris
63Laboratory of Epidemiology, Demography, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892–9205, United States
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Juliette M. Harris
78Department of Twin Research and Genetic Epidemiology, King’s College London, London, SE1 7EH, UK
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Elizabeth G. Holliday
35Public Health Stream, Hunter Medical Research Institute, New Lambton, NSW 2305 Australia
36Faculty of Health and Medicine, University of Newcastle, Newcastle, NSW 2300 Australia
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Jouke-Jan Hottenga
4Department of Biological Psychology, Vrije Universiteit, Amsterdam, 1081 BT, The Netherlands
5EMGO+ Institute for Health and Care Research, Amsterdam, 1081 BT, The Netherlands
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Philip L. De Jager
64Program in Translational NeuroPsychiatric Genomics, Departments of Neurology & Psychiatry, Brigham and Women’s Hospital, Boston, MA 02115, USA
65Harvard Medical School, Boston, MA 02115, USA
66Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, 02142, USA
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Marika A. Kaakinen
67Department of Genomics of Common Disease, Imperial College London, London, W12 0NN, UK
70Center for Life Course Health Research, University of Oulu; Oulu University Hospital, Oulu Finland
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Eero Kajantie
68Department of Pediatrics, University of Helsinki, Helsinki Finland
69National Institute for Health and Welfare, Helsinki Finland
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Ville Karhunen
70Center for Life Course Health Research, University of Oulu; Oulu University Hospital, Oulu Finland
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Ivana Kolcic
114Department of Public Health, Faculty of Medicine, University of Split, Croatia, Split 21000 Croatia
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Meena Kumari
71Institute for Social & Economic Research, University of Essex, Wivenhoe Park CO4 3SQ, UK
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Lenore J. Launer
72Neuroepidemiology Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892-9205, USA
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LifeLines Cohort Study
73LifeLines Cohort Study, University of Groningen, University Medical Center Groningen, Groningen, 9713 BZ, The Netherlands
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Ruifang Li-Gao
31Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands
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Marisa Loitfelder
117Department of Neurology, General Hospital and Medical University Graz, Graz, 8036 Austria
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Anu Loukola
16Department of Public Health, University of Helsinki, Helsinki, FI-00014 Finland
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Pedro Marques-Vidal
74Department of Internal Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, 1011 Switzerland
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Grant W. Montgomery
75Molecular Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029 Australia
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Lavinia Paternoster
47MRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK
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Alison Pattie
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25IBS, Unit of Personality, Work and Health, Institute of Behavioural Sciences, P.O. Box 9, 00014 University of Helsinki Finland
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25IBS, Unit of Personality, Work and Health, Institute of Behavioural Sciences, P.O. Box 9, 00014 University of Helsinki Finland
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80Information Based Medicine Stream, Hunter Medical Research Institute, New Lambton, NSW 2305 Australia
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51Department of Epidemiology, University of Michigan, Ann Arbor, MI 48104, USA
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121Department of Geriatrics, Florida State University College of Medicine, Tallahassee, FL 32306, USA
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127Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072 Australia
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116Research Unit for Genetic Epidemiology, Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, General Hospital and Medical University, Graz, Graz, 8010 Austria
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56German Socio-Economic Panel Study, DIW Berlin, Berlin, 10117 Germany
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59Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI 48104, USA
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127Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072 Australia
128The University of Queensland Diamantina Institute, The Translation Research Institute, Brisbane, QLD 4102 Australia
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129Department of Sociology, New York University, New York, NY 10012, USA
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133New York Genome Center, New York, NY 10013, USA
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Philipp D. Koellinger
9Department of Complex Trait Genetics, VU University, Center for Neurogenomics and Cognitive Research, Amsterdam, 1081 HV, The Netherlands
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Summary

We conducted a genome-wide association study of subjective well-being (SWB) in 298,420 individuals. We also performed auxiliary analyses of depressive symptoms (“DS”; N = 161,460) and neuroticism (N = 170,910), both of which have a substantial genetic correlation with SWB Embedded Image. We identify three SNPs associated with SWB at genome-wide significance. Two of them are significantly associated with DS in an independent sample. In our auxiliary analyses, we identify 13 additional genome-wide-significant associations: two with DS and eleven with neuroticism, including two inversion polymorphisms. Across our phenotypes, loci regulating expression in central nervous system and adrenal/pancreas tissues are enriched. The discovery of genetic loci associated with the three phenotypes we study has proven elusive; our findings illustrate the payoffs from studying them jointly.

One Sentence Summary: Using both genome-wide association studies and proxy-phenotype studies, we identify genetic variants associated with subjective well-being, depressive symptoms, and neuroticism.

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Posted November 24, 2015.
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Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism
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Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism
Aysu Okbay, Bart M.L. Baselmans, Jan-Emmanuel De Neve, Patrick Turley, Michel G. Nivard, Mark A. Fontana, S. Fleur W. Meddens, Richard Karlsson Linnér, Cornelius A. Rietveld, Jaime Derringer, Jacob Gratten, James J. Lee, Jimmy Z. Liu, Ronald de Vlaming, Tarunveer S. Ahluwalia, Jadwiga Buchwald, Alana Cavadino, Alexis C. Frazier-Wood, Nicholas A. Furlotte, Victoria Garfield, Marie Henrike Geisel, Juan R. Gonzalez, Saskia Haitjema, Robert Karlsson, Sander W. van der Laan, Karl-Heinz Ladwig, Jari Lahti, Sven J. van der Lee, Penelope A. Lind, Tian Liu, Lindsay Matteson, Evelin Mihailov, Michael B. Miller, Camelia C. Minica, Ilja M. Nolte, Dennis Mook-Kanamori, Peter J. van der Most, Christopher Oldmeadow, Yong Qian, Olli Raitakari, Rajesh Rawal, Anu Realo, Rico Rueedi, Börge Schmidt, Albert V. Smith, Evie Stergiakouli, Toshiko Tanaka, Kent Taylor, Juho Wedenoja, Juergen Wellmann, Harm-Jan Westra, Sara M. Willems, Wei Zhao, Behrooz Z. Alizadeh, Najaf Amin, Andrew Bakshi, Patricia A. Boyle, Simon Cox, Gail Davies, Oliver S.P. Davis, Jun Ding, Nese Direk, Peter Eibich, Rebecca T. Emeny, Ghazaleh Fatemifar, Jessica D. Faul, Luigi Ferrucci, Andreas J. Forstner, Christian Gieger, Tamara B. Harris, Juliette M. Harris, Elizabeth G. Holliday, Jouke-Jan Hottenga, Philip L. De Jager, Marika A. Kaakinen, Eero Kajantie, Ville Karhunen, Ivana Kolcic, Meena Kumari, Lenore J. Launer, LifeLines Cohort Study, Ruifang Li-Gao, Marisa Loitfelder, Anu Loukola, Pedro Marques-Vidal, Grant W. Montgomery, Lavinia Paternoster, Alison Pattie, Katja E. Petrovic, Laura Pulkki-Råback, Lydia Quaye, Katri Räikkönen, Igor Rudan, Rodney J. Scott, Jennifer A. Smith, Angelina R. Sutin, Maciej Trzaskowski, Anna E. Vinkhuyzen, Lei Yu, Delilah Zabaneh, John R. Attia, David A. Bennett, Klaus Berger, Lars Bertram, Dorret I. Boomsma, Ute Bultmann, Shun-Chiao Chang, Francesco Cucca, Ian J. Deary, Cornelia M. van Duijn, Johan G. Eriksson, Lude Franke, Eco J.C. de Geus, Patrick J.F. Groenen, Vilmundur Gudnason, Torben Hansen, Catharine A. Hartman, Claire M.A. Haworth, Caroline Hayward, Andrew C. Heath, David A. Hinds, Elina Hyppönen, William G. Iacono, Marjo-Riitta Järvelin, Karl-Heinz Jöckel, Jaakko Kaprio, Sharon L.R. Kardia, Liisa Keltikangas-Järvinen, Peter Kraft, Laura Kubzansky, Terho Lehtimäki, Patrik K.E. Magnusson, Nicholas G. Martin, Matt McGue, Andres Metspalu, Melinda Mills, Renée de Mutsert, Albertine J. Oldehinkel, Gerard Pasterkamp, Nancy L. Pedersen, Robert Plomin, Ozren Polasek, Christine Power, Stephen S. Rich, Frits R. Rosendaal, Hester M. den Ruijter, David Schlessinger, Helena Schmidt, Rauli Svento, Reinhold Schmidt, Harold Snieder, Thorkild I.A. Sørensen, Tim D. Spector, Andrew Steptoe, Antonio Terracciano, A. Roy Thurik, Nicholas J. Timpson, Henning Tiemeier, André G. Uitterlinden, Peter Vollenweider, Gert Wagner, David R. Weir, Jian Yang, Dalton C. Conley, George Davey Smith, Albert Hofman, Magnus Johannesson, David I. Laibson, Sarah E. Medland, Michelle N. Meyer, Joseph K. Pickrell, Tõnu Esko, Robert F. Krueger, Jonathan P. Beauchamp, Philipp D. Koellinger, Daniel J. Benjamin, Meike Bartels, David Cesarini
bioRxiv 032789; doi: https://doi.org/10.1101/032789
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Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism
Aysu Okbay, Bart M.L. Baselmans, Jan-Emmanuel De Neve, Patrick Turley, Michel G. Nivard, Mark A. Fontana, S. Fleur W. Meddens, Richard Karlsson Linnér, Cornelius A. Rietveld, Jaime Derringer, Jacob Gratten, James J. Lee, Jimmy Z. Liu, Ronald de Vlaming, Tarunveer S. Ahluwalia, Jadwiga Buchwald, Alana Cavadino, Alexis C. Frazier-Wood, Nicholas A. Furlotte, Victoria Garfield, Marie Henrike Geisel, Juan R. Gonzalez, Saskia Haitjema, Robert Karlsson, Sander W. van der Laan, Karl-Heinz Ladwig, Jari Lahti, Sven J. van der Lee, Penelope A. Lind, Tian Liu, Lindsay Matteson, Evelin Mihailov, Michael B. Miller, Camelia C. Minica, Ilja M. Nolte, Dennis Mook-Kanamori, Peter J. van der Most, Christopher Oldmeadow, Yong Qian, Olli Raitakari, Rajesh Rawal, Anu Realo, Rico Rueedi, Börge Schmidt, Albert V. Smith, Evie Stergiakouli, Toshiko Tanaka, Kent Taylor, Juho Wedenoja, Juergen Wellmann, Harm-Jan Westra, Sara M. Willems, Wei Zhao, Behrooz Z. Alizadeh, Najaf Amin, Andrew Bakshi, Patricia A. Boyle, Simon Cox, Gail Davies, Oliver S.P. Davis, Jun Ding, Nese Direk, Peter Eibich, Rebecca T. Emeny, Ghazaleh Fatemifar, Jessica D. Faul, Luigi Ferrucci, Andreas J. Forstner, Christian Gieger, Tamara B. Harris, Juliette M. Harris, Elizabeth G. Holliday, Jouke-Jan Hottenga, Philip L. De Jager, Marika A. Kaakinen, Eero Kajantie, Ville Karhunen, Ivana Kolcic, Meena Kumari, Lenore J. Launer, LifeLines Cohort Study, Ruifang Li-Gao, Marisa Loitfelder, Anu Loukola, Pedro Marques-Vidal, Grant W. Montgomery, Lavinia Paternoster, Alison Pattie, Katja E. Petrovic, Laura Pulkki-Råback, Lydia Quaye, Katri Räikkönen, Igor Rudan, Rodney J. Scott, Jennifer A. Smith, Angelina R. Sutin, Maciej Trzaskowski, Anna E. Vinkhuyzen, Lei Yu, Delilah Zabaneh, John R. Attia, David A. Bennett, Klaus Berger, Lars Bertram, Dorret I. Boomsma, Ute Bultmann, Shun-Chiao Chang, Francesco Cucca, Ian J. Deary, Cornelia M. van Duijn, Johan G. Eriksson, Lude Franke, Eco J.C. de Geus, Patrick J.F. Groenen, Vilmundur Gudnason, Torben Hansen, Catharine A. Hartman, Claire M.A. Haworth, Caroline Hayward, Andrew C. Heath, David A. Hinds, Elina Hyppönen, William G. Iacono, Marjo-Riitta Järvelin, Karl-Heinz Jöckel, Jaakko Kaprio, Sharon L.R. Kardia, Liisa Keltikangas-Järvinen, Peter Kraft, Laura Kubzansky, Terho Lehtimäki, Patrik K.E. Magnusson, Nicholas G. Martin, Matt McGue, Andres Metspalu, Melinda Mills, Renée de Mutsert, Albertine J. Oldehinkel, Gerard Pasterkamp, Nancy L. Pedersen, Robert Plomin, Ozren Polasek, Christine Power, Stephen S. Rich, Frits R. Rosendaal, Hester M. den Ruijter, David Schlessinger, Helena Schmidt, Rauli Svento, Reinhold Schmidt, Harold Snieder, Thorkild I.A. Sørensen, Tim D. Spector, Andrew Steptoe, Antonio Terracciano, A. Roy Thurik, Nicholas J. Timpson, Henning Tiemeier, André G. Uitterlinden, Peter Vollenweider, Gert Wagner, David R. Weir, Jian Yang, Dalton C. Conley, George Davey Smith, Albert Hofman, Magnus Johannesson, David I. Laibson, Sarah E. Medland, Michelle N. Meyer, Joseph K. Pickrell, Tõnu Esko, Robert F. Krueger, Jonathan P. Beauchamp, Philipp D. Koellinger, Daniel J. Benjamin, Meike Bartels, David Cesarini
bioRxiv 032789; doi: https://doi.org/10.1101/032789

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