New Results
Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism
View ORCID ProfileAysu Okbay, View ORCID ProfileBart M.L. Baselmans, View ORCID ProfileJan-Emmanuel De Neve, View ORCID ProfilePatrick Turley, View ORCID ProfileMichel G. Nivard, View ORCID ProfileMark A. Fontana, View ORCID ProfileS. Fleur W. Meddens, View ORCID ProfileRichard Karlsson Linnér, View ORCID ProfileCornelius A. Rietveld, View ORCID ProfileJaime Derringer, View ORCID ProfileJacob Gratten, View ORCID ProfileJames J. Lee, View ORCID ProfileJimmy Z. Liu, View ORCID ProfileRonald de Vlaming, Tarunveer S. Ahluwalia, Jadwiga Buchwald, Alana Cavadino, Alexis C. Frazier-Wood, Nicholas A. Furlotte, Victoria Garfield, Marie Henrike Geisel, Juan R. Gonzalez, Saskia Haitjema, Robert Karlsson, Sander W. van der Laan, Karl-Heinz Ladwig, Jari Lahti, Sven J. van der Lee, Penelope A. Lind, Tian Liu, Lindsay Matteson, Evelin Mihailov, Michael B. Miller, Camelia C. Minica, Ilja M. Nolte, Dennis Mook-Kanamori, Peter J. van der Most, Christopher Oldmeadow, Yong Qian, Olli Raitakari, Rajesh Rawal, Anu Realo, Rico Rueedi, Börge Schmidt, View ORCID ProfileAlbert V. Smith, Evie Stergiakouli, Toshiko Tanaka, Kent Taylor, Juho Wedenoja, Juergen Wellmann, Harm-Jan Westra, Sara M. Willems, Wei Zhao, Behrooz Z. Alizadeh, View ORCID ProfileNajaf Amin, Andrew Bakshi, Patricia A. Boyle, Simon Cox, Gail Davies, Oliver S.P. Davis, Jun Ding, Nese Direk, Peter Eibich, Rebecca T. Emeny, Ghazaleh Fatemifar, Jessica D. Faul, Luigi Ferrucci, Andreas J. Forstner, Christian Gieger, Tamara B. Harris, Juliette M. Harris, Elizabeth G. Holliday, Jouke-Jan Hottenga, Philip L. De Jager, Marika A. Kaakinen, Eero Kajantie, Ville Karhunen, Ivana Kolcic, Meena Kumari, Lenore J. Launer, LifeLines Cohort Study, Ruifang Li-Gao, Marisa Loitfelder, Anu Loukola, Pedro Marques-Vidal, Grant W. Montgomery, Lavinia Paternoster, Alison Pattie, Katja E. Petrovic, Laura Pulkki-Råback, Lydia Quaye, Katri Räikkönen, Igor Rudan, Rodney J. Scott, Jennifer A. Smith, Angelina R. Sutin, Maciej Trzaskowski, Anna E. Vinkhuyzen, Lei Yu, Delilah Zabaneh, John R. Attia, David A. Bennett, Klaus Berger, Lars Bertram, Dorret I. Boomsma, Ute Bultmann, Shun-Chiao Chang, Francesco Cucca, Ian J. Deary, Cornelia M. van Duijn, Johan G. Eriksson, Lude Franke, Eco J.C. de Geus, Patrick J.F. Groenen, Vilmundur Gudnason, Torben Hansen, Catharine A. Hartman, Claire M.A. Haworth, Caroline Hayward, Andrew C. Heath, David A. Hinds, Elina Hyppönen, William G. Iacono, Marjo-Riitta Järvelin, Karl-Heinz Jöckel, Jaakko Kaprio, Sharon L.R. Kardia, Liisa Keltikangas-Järvinen, Peter Kraft, Laura Kubzansky, Terho Lehtimäki, Patrik K.E. Magnusson, Nicholas G. Martin, Matt McGue, Andres Metspalu, Melinda Mills, Renée de Mutsert, Albertine J. Oldehinkel, Gerard Pasterkamp, Nancy L. Pedersen, Robert Plomin, Ozren Polasek, Christine Power, Stephen S. Rich, Frits R. Rosendaal, Hester M. den Ruijter, David Schlessinger, Helena Schmidt, Rauli Svento, Reinhold Schmidt, Harold Snieder, Thorkild I.A. Sørensen, Tim D. Spector, Andrew Steptoe, Antonio Terracciano, A. Roy Thurik, Nicholas J. Timpson, Henning Tiemeier, André G. Uitterlinden, Peter Vollenweider, Gert Wagner, David R. Weir, Jian Yang, View ORCID ProfileDalton C. Conley, George Davey Smith, View ORCID ProfileAlbert Hofman, View ORCID ProfileMagnus Johannesson, View ORCID ProfileDavid I. Laibson, View ORCID ProfileSarah E. Medland, View ORCID ProfileMichelle N. Meyer, View ORCID ProfileJoseph K. Pickrell, View ORCID ProfileTõnu Esko, View ORCID ProfileRobert F. Krueger, View ORCID ProfileJonathan P. Beauchamp, View ORCID ProfilePhilipp D. Koellinger, Daniel J. Benjamin, View ORCID ProfileMeike Bartels, View ORCID ProfileDavid Cesarini
doi: https://doi.org/10.1101/032789
Aysu Okbay
Department of Applied Economics, Erasmus School of Economics, Erasmus University Rotterdam, 3062 PA, Rotterdam, The Netherlands
Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, 3062 PA, The Netherlands
Bart M.L. Baselmans
Department of Biological Psychology, Vrije Universiteit, Amsterdam, 1081 BT, The Netherlands
EMGO+ Institute for Health and Care Research, Amsterdam, 1081 BT, The Netherlands
Jan-Emmanuel De Neve
Saïd Business School, University of Oxford, Oxford, OX1 1HP, UK
Patrick Turley
Department of Economics, Harvard University, Cambridge, MA 02138, USA
Michel G. Nivard
Department of Biological Psychology, Vrije Universiteit, Amsterdam, 1081 BT, The Netherlands
Mark A. Fontana
Department of Economics, University of Michigan, Ann Arbor, MI 48109–1220, USA
S. Fleur W. Meddens
Department of Complex Trait Genetics, VU University, Center for Neurogenomics and Cognitive Research, Amsterdam, 1081 HV, The Netherlands
Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, 3062 PA, The Netherlands
Amsterdam Business School, University of Amsterdam, Amsterdam, 1018 TV, The Netherlands
Richard Karlsson Linnér
Department of Complex Trait Genetics, VU University, Center for Neurogenomics and Cognitive Research, Amsterdam, 1081 HV, The Netherlands
Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, 3062 PA, The Netherlands
Amsterdam Business School, University of Amsterdam, Amsterdam, 1018 TV, The Netherlands
Cornelius A. Rietveld
Department of Applied Economics, Erasmus School of Economics, Erasmus University Rotterdam, 3062 PA, Rotterdam, The Netherlands
Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, 3062 PA, The Netherlands
Jaime Derringer
Psychology, University of Illinois, IL 61820, Champaign, USA
Jacob Gratten
Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072 Australia
James J. Lee
Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN 55455, USA
Jimmy Z. Liu
New York Genome Center, New York, NY 10013, USA
Ronald de Vlaming
Department of Applied Economics, Erasmus School of Economics, Erasmus University Rotterdam, 3062 PA, Rotterdam, The Netherlands
Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, 3062 PA, The Netherlands
Tarunveer S. Ahluwalia
COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, 2820 Denmark
The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, 2100 Denmark
Steno Diabetes Center, Gentofte, 2820 Denmark
Jadwiga Buchwald
Department of Public Health, University of Helsinki, Helsinki, FI-00014 Finland
Alana Cavadino
Centre for Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London EC1M 6BQ, UK
Population, Policy and Practice, UCL Institute of Child Health, London, WC1N 1EH, UK
Alexis C. Frazier-Wood
USDA/ARS Children’s Nutrition Research Center, Baylor College of Medicine, Houston, TX 77030, USA
Nicholas A. Furlotte
23andMe, Inc., Mountain View, CA 94041, USA
Victoria Garfield
Department of Epidemiology & Public Health, University College London, London WC1E 7HB, UK
Marie Henrike Geisel
Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Essen, 45147 Germany
Juan R. Gonzalez
Centre for Research in Environmental Epidemiology, Institute for Global Health, Barcelona Spain
Universitat Pompeu Fabra, Barcelona Spain
CIBER Epidemiología y Salud Pública, Barcelona Spain
Saskia Haitjema
Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands
Robert Karlsson
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, 171 77 Sweden
Sander W. van der Laan
Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands
Karl-Heinz Ladwig
Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764 Germany
Jari Lahti
IBS, Unit of Personality, Work and Health, Institute of Behavioural Sciences, P.O. Box 9, 00014 University of Helsinki Finland
Folkhälsan Research Centre, Helsingfors, FI-00014 Finland
Helsinki Collegium for Advanced Studies, University of Helsinki, Helsinki 00014 Finland
Sven J. van der Lee
Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
Penelope A. Lind
Quantitative Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029 Australia
Tian Liu
Lifespan Psychology, Max Planck Institute for Human Development, Berlin, 14195 Germany
Max Planck Institute for Molecular Genetics, Department of Vertebrate Genomics, Berlin, 14195 Germany
Lindsay Matteson
Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN 55455, USA
Evelin Mihailov
Estonian Genome Center, University of Tartu, Tartu, 51010 Estonia
Michael B. Miller
Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN 55455, USA
Camelia C. Minica
Department of Biological Psychology, Vrije Universiteit, Amsterdam, 1081 BT, The Netherlands
Ilja M. Nolte
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands
Dennis Mook-Kanamori
Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands
Public Health and Primary Care, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands
BESC, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia
Peter J. van der Most
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands
Christopher Oldmeadow
Public Health Stream, Hunter Medical Research Institute, New Lambton, NSW 2305 Australia
Faculty of Health and Medicine, University of Newcastle, Newcastle, NSW 2300 Australia
Yong Qian
Laboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA
Olli Raitakari
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, 20521 Finland
Department of Clinical Physiology, Turku University Hospital, Turku 20520 Finland
Rajesh Rawal
Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764 Germany
Anu Realo
Department of Psychology, University of Tartu, Tartu 50409 Estonia
Rico Rueedi
Department of Medical Genetics, University of Lausanne, Lausanne, 1005 Switzerland
Swiss Institute of Bioinformatics, Lausanne, 1015 Switzerland
Börge Schmidt
Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Essen, 45147 Germany
Albert V. Smith
Icelandic Heart Association, Kopavogur, 201 Iceland
Faculty of Medicine, University of Iceland, Reykjavik, 101 Iceland
Evie Stergiakouli
MRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK
Toshiko Tanaka
National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Kent Taylor
Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA, Torrence, 90505 CA, USA
Juho Wedenoja
Department of Public Health, University of Helsinki, Helsinki, FI-00014 Finland
Juergen Wellmann
Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, 48149 Germany
Harm-Jan Westra
Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
Sara M. Willems
Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
Wei Zhao
Department of Epidemiology, University of Michigan, Ann Arbor, MI 48104, USA
Behrooz Z. Alizadeh
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands
Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, The Netherlands
Najaf Amin
Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
Andrew Bakshi
Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072 Australia
Patricia A. Boyle
Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Simon Cox
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK
Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK
Gail Davies
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK
Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK
Oliver S.P. Davis
MRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK
Jun Ding
Laboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA
Nese Direk
Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
Peter Eibich
German Socio-Economic Panel Study, DIW Berlin, Berlin, 10117 Germany
Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK
Rebecca T. Emeny
Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764 Germany
Ghazaleh Fatemifar
The Farr Institute of Health Informatics, University College London, London NW1 2DA, UK
Jessica D. Faul
Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI 48104, USA
Luigi Ferrucci
National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Andreas J. Forstner
Institute of Human Genetics, University of Bonn, Bonn, 53127 Germany
Department of Genomics, Life and Brain Center, University of Bonn, Bonn, 53127 Germany
Christian Gieger
Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764 Germany
Tamara B. Harris
Laboratory of Epidemiology, Demography, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892–9205, United States
Juliette M. Harris
Department of Twin Research and Genetic Epidemiology, King’s College London, London, SE1 7EH, UK
Elizabeth G. Holliday
Public Health Stream, Hunter Medical Research Institute, New Lambton, NSW 2305 Australia
Faculty of Health and Medicine, University of Newcastle, Newcastle, NSW 2300 Australia
Jouke-Jan Hottenga
Department of Biological Psychology, Vrije Universiteit, Amsterdam, 1081 BT, The Netherlands
EMGO+ Institute for Health and Care Research, Amsterdam, 1081 BT, The Netherlands
Philip L. De Jager
Program in Translational NeuroPsychiatric Genomics, Departments of Neurology & Psychiatry, Brigham and Women’s Hospital, Boston, MA 02115, USA
Harvard Medical School, Boston, MA 02115, USA
Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, 02142, USA
Marika A. Kaakinen
Department of Genomics of Common Disease, Imperial College London, London, W12 0NN, UK
Center for Life Course Health Research, University of Oulu; Oulu University Hospital, Oulu Finland
Eero Kajantie
Department of Pediatrics, University of Helsinki, Helsinki Finland
National Institute for Health and Welfare, Helsinki Finland
Ville Karhunen
Center for Life Course Health Research, University of Oulu; Oulu University Hospital, Oulu Finland
Ivana Kolcic
Department of Public Health, Faculty of Medicine, University of Split, Croatia, Split 21000 Croatia
Meena Kumari
Institute for Social & Economic Research, University of Essex, Wivenhoe Park CO4 3SQ, UK
Lenore J. Launer
Neuroepidemiology Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892-9205, USA
LifeLines Cohort Study
LifeLines Cohort Study, University of Groningen, University Medical Center Groningen, Groningen, 9713 BZ, The Netherlands
Ruifang Li-Gao
Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands
Marisa Loitfelder
Department of Neurology, General Hospital and Medical University Graz, Graz, 8036 Austria
Anu Loukola
Department of Public Health, University of Helsinki, Helsinki, FI-00014 Finland
Pedro Marques-Vidal
Department of Internal Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, 1011 Switzerland
Grant W. Montgomery
Molecular Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029 Australia
Lavinia Paternoster
MRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK
Alison Pattie
Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK
Katja E. Petrovic
Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK
Laura Pulkki-Råback
IBS, Unit of Personality, Work and Health, Institute of Behavioural Sciences, P.O. Box 9, 00014 University of Helsinki Finland
Helsinki Collegium for Advanced Studies, University of Helsinki, Helsinki 00014 Finland
Lydia Quaye
Department of Twin Research and Genetic Epidemiology, King’s College London, London, SE1 7EH, UK
Katri Räikkönen
IBS, Unit of Personality, Work and Health, Institute of Behavioural Sciences, P.O. Box 9, 00014 University of Helsinki Finland
Igor Rudan
Centre for Global Health Research, The Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK
Rodney J. Scott
Information Based Medicine Stream, Hunter Medical Research Institute, New Lambton, NSW 2305 Australia
Faculty of Health and Medicine, University of Newcastle, Newcastle, NSW 2300 Australia
Jennifer A. Smith
Department of Epidemiology, University of Michigan, Ann Arbor, MI 48104, USA
Angelina R. Sutin
Department of Geriatrics, Florida State University College of Medicine, Tallahassee, FL 32306, USA
National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Maciej Trzaskowski
Social, Genetic and Developmental Psychiatry Centre, King’s College London, De Crespigny Park SE5 8AF, UK
Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072 Australia
Anna E. Vinkhuyzen
Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072 Australia
Lei Yu
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Delilah Zabaneh
Social, Genetic and Developmental Psychiatry Centre, King’s College London, De Crespigny Park SE5 8AF, UK
John R. Attia
Public Health Stream, Hunter Medical Research Institute, New Lambton, NSW 2305 Australia
Faculty of Health and Medicine, University of Newcastle, Newcastle, NSW 2300 Australia
David A. Bennett
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Klaus Berger
Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, 48149 Germany
Lars Bertram
Lübeck Interdisciplinary platform for Genome Analytics (LIGA), Institutes of Neurogenetics and Integrative & Experimental Genomics, University of Lübeck, Lübeck, 23562 Germany
Neuroepidemiology and Ageing Research Unit, School of Public Health, Faculty of Medicine, Imperial College, London SW7 2AZ, UK
Dorret I. Boomsma
Department of Biological Psychology, Vrije Universiteit, Amsterdam, 1081 BT, The Netherlands
EMGO+ Institute for Health and Care Research, Amsterdam, 1081 BT, The Netherlands
Neuroscience Campus Amsterdam, Amsterdam, The Netherlands
Ute Bultmann
Department of Health Sciences, Community & Occupational Medicine, University of Groningen, University Medical Center Groningen, Groningen, 9713 AV, The Netherlands
Shun-Chiao Chang
Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA
Francesco Cucca
Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari, 9042 Italy
Ian J. Deary
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK
Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK
Cornelia M. van Duijn
Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
Johan G. Eriksson
Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, 00014 Finland
Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki Finland
Unit of General Practice, University Central Hospital, Helsinki Finland
Lude Franke
Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen. 9700 RB, The Netherlands
Eco J.C. de Geus
Department of Biological Psychology, Vrije Universiteit, Amsterdam, 1081 BT, The Netherlands
EMGO+ Institute for Health and Care Research, Amsterdam, 1081 BT, The Netherlands
Neuroscience Campus Amsterdam, Amsterdam, The Netherlands
Patrick J.F. Groenen
Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, 3062 PA, The Netherlands
Econometric Institute, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, 3062 PA, The Netherlands
Vilmundur Gudnason
Icelandic Heart Association, Kopavogur, 201 Iceland
Faculty of Medicine, University of Iceland, Reykjavik, 101 Iceland
Torben Hansen
The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, 2100 Denmark
Catharine A. Hartman
Department of Psychiatry, University of Groningen, University Medical Center Groningen, 9700 RB, Groningen, The Netherlands
Claire M.A. Haworth
MRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK
Caroline Hayward
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK
Generation Scotland, Centre for Genomics and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK
Andrew C. Heath
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA
David A. Hinds
23andMe, Inc., Mountain View, CA 94041, USA
Elina Hyppönen
Centre for Population Health Research, School of Health Sciences and Sansom Institute, University of South Australia, SA5000, Adelaide Australia
South Australian Health and Medical Research Institute, Adelaide, SA5000 Australia
Population, Policy and Practice, UCL Institute of Child Health, London, WC1N 1EH, UK
William G. Iacono
Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN 55455, USA
Marjo-Riitta Järvelin
Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPE) Centre for Environment and Health, School of Public Health, Imperial College London, UK
Biocenter Oulu, University of Oulu, Oulu Finland
Center for Life Course Health Research, University of Oulu; Oulu University Hospital, Oulu Finland
Unit of Primary Care, Oulu University Hospital, Oulu Finland
Karl-Heinz Jöckel
Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Essen, 45147 Germany
Jaakko Kaprio
Department of Public Health, University of Helsinki, Helsinki, FI-00014 Finland
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, 00014 Finland
Department for Health, THL-National Institute for Health and Welfare, Helsinki, FI-00271 Finland
Sharon L.R. Kardia
Department of Epidemiology, University of Michigan, Ann Arbor, MI 48104, USA
Liisa Keltikangas-Järvinen
IBS, Unit of Personality, Work and Health, Institute of Behavioural Sciences, P.O. Box 9, 00014 University of Helsinki Finland
Peter Kraft
Department of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA
Laura Kubzansky
Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA
Terho Lehtimäki
Fimlab Laboratories, Tampere, 33520 Finland
Department of Clinical Chemistry, University of Tampere, School of Medicine, Tampere, 33014 Finland
Patrik K.E. Magnusson
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, 171 77 Sweden
Nicholas G. Martin
Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029 Australia
Matt McGue
Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN 55455, USA
Andres Metspalu
Estonian Genome Center, University of Tartu, Tartu, 51010 Estonia
Institute of Molecular and Cell Biology, University of Tartu, Tartu, 51010 Estonia
Melinda Mills
Department of Sociology, University of Oxford, Oxford OX1 3UQ, UK
Renée de Mutsert
Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands
Albertine J. Oldehinkel
Department of Psychiatry, University of Groningen, University Medical Center Groningen, 9700 RB, Groningen, The Netherlands
Gerard Pasterkamp
Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands
Laboratory of Clinical Chemistry and Hematology, Division Laboratories and Pharmacy, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands
Nancy L. Pedersen
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, 171 77 Sweden
Robert Plomin
Social, Genetic and Developmental Psychiatry Centre, King’s College London, De Crespigny Park SE5 8AF, UK
Ozren Polasek
Department of Public Health, Faculty of Medicine, University of Split, Croatia, Split 21000 Croatia
Christine Power
Population, Policy and Practice, UCL Institute of Child Health, London, WC1N 1EH, UK
Stephen S. Rich
Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22904, USA
Frits R. Rosendaal
Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands
Hester M. den Ruijter
Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands
David Schlessinger
Laboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA
Helena Schmidt
Research Unit for Genetic Epidemiology, Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, General Hospital and Medical University, Graz, Graz, 8010 Austria
Department of Neurology, General Hospital and Medical University Graz, Graz, 8036 Austria
Rauli Svento
Department of Economics, Oulu Business School, Oulu Finland
Reinhold Schmidt
Department of Neurology, General Hospital and Medical University Graz, Graz, 8036 Austria
Harold Snieder
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands
Thorkild I.A. Sørensen
The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, 2100 Denmark
MRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK
Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, The Capital Region, Frederiksberg, 2000 Denmark
Tim D. Spector
Department of Twin Research and Genetic Epidemiology, King’s College London, London, SE1 7EH, UK
Andrew Steptoe
Department of Epidemiology & Public Health, University College London, London WC1E 7HB, UK
Antonio Terracciano
Department of Geriatrics, Florida State University College of Medicine, Tallahassee, FL 32306, USA
National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
A. Roy Thurik
Department of Applied Economics, Erasmus School of Economics, Erasmus University Rotterdam, 3062 PA, Rotterdam, The Netherlands
Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, 3062 PA, The Netherlands
Montpellier Business School, Montpellier, 34080 France
Panteia, Zoetermeer, 2715 CA, The Netherlands
Nicholas J. Timpson
MRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK
Henning Tiemeier
Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
Department of Psychiatry, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
Department of Child and Adolescent Psychiatry, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
André G. Uitterlinden
Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, 3062 PA, The Netherlands
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
Peter Vollenweider
Department of Internal Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, 1011 Switzerland
Gert Wagner
German Socio-Economic Panel Study, DIW Berlin, Berlin, 10117 Germany
David R. Weir
Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI 48104, USA
Jian Yang
Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072 Australia
The University of Queensland Diamantina Institute, The Translation Research Institute, Brisbane, QLD 4102 Australia
Dalton C. Conley
Department of Sociology, New York University, New York, NY 10012, USA
School of Medicine, New York University, NY 10016, New York, USA
George Davey Smith
MRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK
Albert Hofman
Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
Magnus Johannesson
Department of Economics, Stockholm School of Economics, Stockholm, 113 83 Sweden
David I. Laibson
Department of Economics, Harvard University, Cambridge, MA 02138, USA
Sarah E. Medland
Quantitative Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029 Australia
Michelle N. Meyer
Bioethics Program, Union Graduate College - Icahn School of Medicine at Mount Sinai, Schenectady, NY 12308, USA
Joseph K. Pickrell
New York Genome Center, New York, NY 10013, USA
Department of Biological Sciences, Columbia University, 600 Fairchild Center, New York, NY 10027, USA
Tõnu Esko
Estonian Genome Center, University of Tartu, Tartu, 51010 Estonia
Robert F. Krueger
Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN 55455, USA
Jonathan P. Beauchamp
Department of Economics, Harvard University, Cambridge, MA 02138, USA
Philipp D. Koellinger
Department of Complex Trait Genetics, VU University, Center for Neurogenomics and Cognitive Research, Amsterdam, 1081 HV, The Netherlands
Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, 3062 PA, The Netherlands
Amsterdam Business School, University of Amsterdam, Amsterdam, 1018 TV, The Netherlands
Daniel J. Benjamin
Center for Economic and Social Research, University of Southern California, Los Angeles, CA 90089-3332, USA
Meike Bartels
Department of Biological Psychology, Vrije Universiteit, Amsterdam, 1081 BT, The Netherlands
EMGO+ Institute for Health and Care Research, Amsterdam, 1081 BT, The Netherlands
Neuroscience Campus Amsterdam, Amsterdam, The Netherlands
David Cesarini
Department of Economics, New York University, New York, NY 10012, USA
Research Institute for Industrial Economics, Stockholm, 10215 Sweden
Summary
We conducted a genome-wide association study of subjective well-being (SWB) in 298,420 individuals. We also performed auxiliary analyses of depressive symptoms (“DS”; N = 161,460) and neuroticism (N = 170,910), both of which have a substantial genetic correlation with SWB 
. We identify three SNPs associated with SWB at genome-wide significance. Two of them are significantly associated with DS in an independent sample. In our auxiliary analyses, we identify 13 additional genome-wide-significant associations: two with DS and eleven with neuroticism, including two inversion polymorphisms. Across our phenotypes, loci regulating expression in central nervous system and adrenal/pancreas tissues are enriched. The discovery of genetic loci associated with the three phenotypes we study has proven elusive; our findings illustrate the payoffs from studying them jointly.
One Sentence Summary: Using both genome-wide association studies and proxy-phenotype studies, we identify genetic variants associated with subjective well-being, depressive symptoms, and neuroticism.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Posted November 24, 2015.
Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism
Aysu Okbay, Bart M.L. Baselmans, Jan-Emmanuel De Neve, Patrick Turley, Michel G. Nivard, Mark A. Fontana, S. Fleur W. Meddens, Richard Karlsson Linnér, Cornelius A. Rietveld, Jaime Derringer, Jacob Gratten, James J. Lee, Jimmy Z. Liu, Ronald de Vlaming, Tarunveer S. Ahluwalia, Jadwiga Buchwald, Alana Cavadino, Alexis C. Frazier-Wood, Nicholas A. Furlotte, Victoria Garfield, Marie Henrike Geisel, Juan R. Gonzalez, Saskia Haitjema, Robert Karlsson, Sander W. van der Laan, Karl-Heinz Ladwig, Jari Lahti, Sven J. van der Lee, Penelope A. Lind, Tian Liu, Lindsay Matteson, Evelin Mihailov, Michael B. Miller, Camelia C. Minica, Ilja M. Nolte, Dennis Mook-Kanamori, Peter J. van der Most, Christopher Oldmeadow, Yong Qian, Olli Raitakari, Rajesh Rawal, Anu Realo, Rico Rueedi, Börge Schmidt, Albert V. Smith, Evie Stergiakouli, Toshiko Tanaka, Kent Taylor, Juho Wedenoja, Juergen Wellmann, Harm-Jan Westra, Sara M. Willems, Wei Zhao, Behrooz Z. Alizadeh, Najaf Amin, Andrew Bakshi, Patricia A. Boyle, Simon Cox, Gail Davies, Oliver S.P. Davis, Jun Ding, Nese Direk, Peter Eibich, Rebecca T. Emeny, Ghazaleh Fatemifar, Jessica D. Faul, Luigi Ferrucci, Andreas J. Forstner, Christian Gieger, Tamara B. Harris, Juliette M. Harris, Elizabeth G. Holliday, Jouke-Jan Hottenga, Philip L. De Jager, Marika A. Kaakinen, Eero Kajantie, Ville Karhunen, Ivana Kolcic, Meena Kumari, Lenore J. Launer, LifeLines Cohort Study, Ruifang Li-Gao, Marisa Loitfelder, Anu Loukola, Pedro Marques-Vidal, Grant W. Montgomery, Lavinia Paternoster, Alison Pattie, Katja E. Petrovic, Laura Pulkki-Råback, Lydia Quaye, Katri Räikkönen, Igor Rudan, Rodney J. Scott, Jennifer A. Smith, Angelina R. Sutin, Maciej Trzaskowski, Anna E. Vinkhuyzen, Lei Yu, Delilah Zabaneh, John R. Attia, David A. Bennett, Klaus Berger, Lars Bertram, Dorret I. Boomsma, Ute Bultmann, Shun-Chiao Chang, Francesco Cucca, Ian J. Deary, Cornelia M. van Duijn, Johan G. Eriksson, Lude Franke, Eco J.C. de Geus, Patrick J.F. Groenen, Vilmundur Gudnason, Torben Hansen, Catharine A. Hartman, Claire M.A. Haworth, Caroline Hayward, Andrew C. Heath, David A. Hinds, Elina Hyppönen, William G. Iacono, Marjo-Riitta Järvelin, Karl-Heinz Jöckel, Jaakko Kaprio, Sharon L.R. Kardia, Liisa Keltikangas-Järvinen, Peter Kraft, Laura Kubzansky, Terho Lehtimäki, Patrik K.E. Magnusson, Nicholas G. Martin, Matt McGue, Andres Metspalu, Melinda Mills, Renée de Mutsert, Albertine J. Oldehinkel, Gerard Pasterkamp, Nancy L. Pedersen, Robert Plomin, Ozren Polasek, Christine Power, Stephen S. Rich, Frits R. Rosendaal, Hester M. den Ruijter, David Schlessinger, Helena Schmidt, Rauli Svento, Reinhold Schmidt, Harold Snieder, Thorkild I.A. Sørensen, Tim D. Spector, Andrew Steptoe, Antonio Terracciano, A. Roy Thurik, Nicholas J. Timpson, Henning Tiemeier, André G. Uitterlinden, Peter Vollenweider, Gert Wagner, David R. Weir, Jian Yang, Dalton C. Conley, George Davey Smith, Albert Hofman, Magnus Johannesson, David I. Laibson, Sarah E. Medland, Michelle N. Meyer, Joseph K. Pickrell, Tõnu Esko, Robert F. Krueger, Jonathan P. Beauchamp, Philipp D. Koellinger, Daniel J. Benjamin, Meike Bartels, David Cesarini
bioRxiv 032789; doi: https://doi.org/10.1101/032789
Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism
Aysu Okbay, Bart M.L. Baselmans, Jan-Emmanuel De Neve, Patrick Turley, Michel G. Nivard, Mark A. Fontana, S. Fleur W. Meddens, Richard Karlsson Linnér, Cornelius A. Rietveld, Jaime Derringer, Jacob Gratten, James J. Lee, Jimmy Z. Liu, Ronald de Vlaming, Tarunveer S. Ahluwalia, Jadwiga Buchwald, Alana Cavadino, Alexis C. Frazier-Wood, Nicholas A. Furlotte, Victoria Garfield, Marie Henrike Geisel, Juan R. Gonzalez, Saskia Haitjema, Robert Karlsson, Sander W. van der Laan, Karl-Heinz Ladwig, Jari Lahti, Sven J. van der Lee, Penelope A. Lind, Tian Liu, Lindsay Matteson, Evelin Mihailov, Michael B. Miller, Camelia C. Minica, Ilja M. Nolte, Dennis Mook-Kanamori, Peter J. van der Most, Christopher Oldmeadow, Yong Qian, Olli Raitakari, Rajesh Rawal, Anu Realo, Rico Rueedi, Börge Schmidt, Albert V. Smith, Evie Stergiakouli, Toshiko Tanaka, Kent Taylor, Juho Wedenoja, Juergen Wellmann, Harm-Jan Westra, Sara M. Willems, Wei Zhao, Behrooz Z. Alizadeh, Najaf Amin, Andrew Bakshi, Patricia A. Boyle, Simon Cox, Gail Davies, Oliver S.P. Davis, Jun Ding, Nese Direk, Peter Eibich, Rebecca T. Emeny, Ghazaleh Fatemifar, Jessica D. Faul, Luigi Ferrucci, Andreas J. Forstner, Christian Gieger, Tamara B. Harris, Juliette M. Harris, Elizabeth G. Holliday, Jouke-Jan Hottenga, Philip L. De Jager, Marika A. Kaakinen, Eero Kajantie, Ville Karhunen, Ivana Kolcic, Meena Kumari, Lenore J. Launer, LifeLines Cohort Study, Ruifang Li-Gao, Marisa Loitfelder, Anu Loukola, Pedro Marques-Vidal, Grant W. Montgomery, Lavinia Paternoster, Alison Pattie, Katja E. Petrovic, Laura Pulkki-Råback, Lydia Quaye, Katri Räikkönen, Igor Rudan, Rodney J. Scott, Jennifer A. Smith, Angelina R. Sutin, Maciej Trzaskowski, Anna E. Vinkhuyzen, Lei Yu, Delilah Zabaneh, John R. Attia, David A. Bennett, Klaus Berger, Lars Bertram, Dorret I. Boomsma, Ute Bultmann, Shun-Chiao Chang, Francesco Cucca, Ian J. Deary, Cornelia M. van Duijn, Johan G. Eriksson, Lude Franke, Eco J.C. de Geus, Patrick J.F. Groenen, Vilmundur Gudnason, Torben Hansen, Catharine A. Hartman, Claire M.A. Haworth, Caroline Hayward, Andrew C. Heath, David A. Hinds, Elina Hyppönen, William G. Iacono, Marjo-Riitta Järvelin, Karl-Heinz Jöckel, Jaakko Kaprio, Sharon L.R. Kardia, Liisa Keltikangas-Järvinen, Peter Kraft, Laura Kubzansky, Terho Lehtimäki, Patrik K.E. Magnusson, Nicholas G. Martin, Matt McGue, Andres Metspalu, Melinda Mills, Renée de Mutsert, Albertine J. Oldehinkel, Gerard Pasterkamp, Nancy L. Pedersen, Robert Plomin, Ozren Polasek, Christine Power, Stephen S. Rich, Frits R. Rosendaal, Hester M. den Ruijter, David Schlessinger, Helena Schmidt, Rauli Svento, Reinhold Schmidt, Harold Snieder, Thorkild I.A. Sørensen, Tim D. Spector, Andrew Steptoe, Antonio Terracciano, A. Roy Thurik, Nicholas J. Timpson, Henning Tiemeier, André G. Uitterlinden, Peter Vollenweider, Gert Wagner, David R. Weir, Jian Yang, Dalton C. Conley, George Davey Smith, Albert Hofman, Magnus Johannesson, David I. Laibson, Sarah E. Medland, Michelle N. Meyer, Joseph K. Pickrell, Tõnu Esko, Robert F. Krueger, Jonathan P. Beauchamp, Philipp D. Koellinger, Daniel J. Benjamin, Meike Bartels, David Cesarini
bioRxiv 032789; doi: https://doi.org/10.1101/032789
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