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Principles of ipsilateral and contralateral cortico-cortical connectivity in the mouse

Alexandros Goulas, Harry BM Uylings, Claus C Hilgetag
doi: https://doi.org/10.1101/033878
Alexandros Goulas
1Department of Computational Neuroscience, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany
2Max Planck Research Group Neuroanatomy and Connectivity, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstraße 1A, 04103 Leipzig, Germany
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  • For correspondence: alexandros.goulas@yahoo.com
Harry BM Uylings
3Department of Anatomy and Neuroscience, VU University Medical Center, Graduate School Neurosciences Amsterdam, 1007 MB, Amsterdam, The Netherlands
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Claus C Hilgetag
1Department of Computational Neuroscience, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany
4Department of Health Sciences, Boston University, 635 Commonwealth Ave., Boston, MA 02215, USA
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Abstract

Structural connectivity among cortical areas provides the substrate for information exchange in the brain and is characterized by the presence or absence of connections between specific areas. What principles govern this cortical wiring diagram? Here, we investigate the relation of physical distance and cytoarchitecture with the connectional architecture of the mouse cortex. Moreover, we examine the relation between patterns of ipsilateral and contralateral connections. Our analysis reveals a mirrored and attenuated organization of contralateral connections when compared to ipsilateral connections. Both spatial proximity and cytoarchitectonic similarity of cortical areas are related to the presence or absence of connections. Notably, our analysis demonstrated that these factors conjointly relate better to cortico-cortical connectivity than each factor in isolation, and that the two factors contribute differently to ipsilateral and contralateral connectivity. Distance is more tightly related to the presence or absence of ipsilateral connections, but its contribution greatly diminishes for contralateral connections, while the contribution of cytoarchitectonic similarity remains stable. Our results, conjointly with similar findings in the cat and macaque cortex, suggest that a common set of principles underlies the macroscale wiring of mammalian brains.

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Posted December 07, 2015.
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Principles of ipsilateral and contralateral cortico-cortical connectivity in the mouse
Alexandros Goulas, Harry BM Uylings, Claus C Hilgetag
bioRxiv 033878; doi: https://doi.org/10.1101/033878
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Principles of ipsilateral and contralateral cortico-cortical connectivity in the mouse
Alexandros Goulas, Harry BM Uylings, Claus C Hilgetag
bioRxiv 033878; doi: https://doi.org/10.1101/033878

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