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Evolutionary dynamics of cytoplasmic segregation and fusion: mitochondrial mixing facilitated the evolution of sex at the origin of eukaryotes

Arunas L. Radzvilavicius
doi: https://doi.org/10.1101/034116
Arunas L. Radzvilavicius
Department of Genetics, Evolution and Environment & CoMPLEX, University College London, Gower street, WC1E 6BT London, United Kingdom
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Abstract

Sexual reproduction is a trait shared by all complex life, but the complete account of its origin is missing. Virtually all theoretical work on the evolution of sex has been centered around the benefits of reciprocal recombination among nuclear genes, paying little attention to the evolutionary dynamics of multi-copy mitochondrial genomes. Here I develop a mathematical model to study the evolution of nuclear alleles inducing cell fusion in an ancestral population of clonal proto-eukaryotes. Segregational drift maintains high mitochondrial variance between clonally reproducing hosts, but the effect of segregation is opposed by cytoplasmic mixing which tends to reduce variation between cells in favor of higher heterogeneity within the cell. Despite the reduced long-term population fitness, alleles responsible for sexual cell fusion can spread to fixation. The evolution of sex requires negative epistatic interactions between mitochondrial mutations under strong purifying selection, low mutation load and weak mitochondrial-nuclear associations. I argue that similar conditions could have been maintained during the late stages of eukaryogenesis, facilitating the evolution of sexual cell fusion and meiotic recombination without compromising the stability of the emerging complex cell.

Highlights

  • Meiotic sex evolved in a cell that already possessed mitochondria

  • Cytoplasmic fusion and mitochondrial mixing evolve under negative epistasis

  • Mitochondrial mixing could have driven the early evolution of sexual life cycles

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted April 07, 2016.
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Evolutionary dynamics of cytoplasmic segregation and fusion: mitochondrial mixing facilitated the evolution of sex at the origin of eukaryotes
Arunas L. Radzvilavicius
bioRxiv 034116; doi: https://doi.org/10.1101/034116
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Evolutionary dynamics of cytoplasmic segregation and fusion: mitochondrial mixing facilitated the evolution of sex at the origin of eukaryotes
Arunas L. Radzvilavicius
bioRxiv 034116; doi: https://doi.org/10.1101/034116

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