Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Hippocampal circuit abnormalities in MeCP2+/− mouse model of Rett syndrome

View ORCID ProfileJulia Chartove, View ORCID ProfileWenlin Liao, View ORCID ProfileAniqa Hassan, View ORCID ProfileMary McMullen, View ORCID ProfileRachel White, View ORCID ProfileSangwon Kim, View ORCID ProfileGregory C. Carlson
doi: https://doi.org/10.1101/034835
Julia Chartove
1Department of Psychiatry, University of Pennsylvania, Philadelphia PA 19312
2Swarthmore College, Swarthmore, PA 19081
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Julia Chartove
  • For correspondence: chartove@bu.edu
Wenlin Liao
1Department of Psychiatry, University of Pennsylvania, Philadelphia PA 19312
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Wenlin Liao
Aniqa Hassan
1Department of Psychiatry, University of Pennsylvania, Philadelphia PA 19312
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Aniqa Hassan
Mary McMullen
1Department of Psychiatry, University of Pennsylvania, Philadelphia PA 19312
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Mary McMullen
Rachel White
1Department of Psychiatry, University of Pennsylvania, Philadelphia PA 19312
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Rachel White
Sangwon Kim
1Department of Psychiatry, University of Pennsylvania, Philadelphia PA 19312
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Sangwon Kim
Gregory C. Carlson
1Department of Psychiatry, University of Pennsylvania, Philadelphia PA 19312
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Gregory C. Carlson
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

Rett syndrome (RTT) has a complex developmental course over childhood and adolescence. Patients with RTT often have a pre-symptomatic period with no or little outward signs of the disorder, followed by developmental arrest and regression. Following regression, the individual’s condition is not static, as they often progress into defined stages with unique neurological symptoms. Similarly, the progression of RTT-like symptoms in female mice heterozygous for a null-mutation has a prodromal and symptomatic period. Change in functional local circuit connectivity was studied using hippocampal slices, assaying Schaffer evoked activity in area CA1 using fast voltage sensitive dye imaging. With this technique the local functional interactions between the excitatory and inhibitory components of the circuit can be characterized. The prodromal period was associated with a shift in extent of excitation into the stratum oriens of the hippocampus and reduced sensitivity to changes in divalent cation concentration. These data suggest that hyperexcitability of the hippocampus at the circuit level may contribute to the prodromal reduction in cognitive performance and the onset of developmental regression.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted December 18, 2015.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Hippocampal circuit abnormalities in MeCP2+/− mouse model of Rett syndrome
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Hippocampal circuit abnormalities in MeCP2+/− mouse model of Rett syndrome
Julia Chartove, Wenlin Liao, Aniqa Hassan, Mary McMullen, Rachel White, Sangwon Kim, Gregory C. Carlson
bioRxiv 034835; doi: https://doi.org/10.1101/034835
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
Hippocampal circuit abnormalities in MeCP2+/− mouse model of Rett syndrome
Julia Chartove, Wenlin Liao, Aniqa Hassan, Mary McMullen, Rachel White, Sangwon Kim, Gregory C. Carlson
bioRxiv 034835; doi: https://doi.org/10.1101/034835

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (4087)
  • Biochemistry (8762)
  • Bioengineering (6479)
  • Bioinformatics (23341)
  • Biophysics (11750)
  • Cancer Biology (9149)
  • Cell Biology (13248)
  • Clinical Trials (138)
  • Developmental Biology (7417)
  • Ecology (11369)
  • Epidemiology (2066)
  • Evolutionary Biology (15087)
  • Genetics (10399)
  • Genomics (14009)
  • Immunology (9121)
  • Microbiology (22040)
  • Molecular Biology (8779)
  • Neuroscience (47368)
  • Paleontology (350)
  • Pathology (1420)
  • Pharmacology and Toxicology (2482)
  • Physiology (3704)
  • Plant Biology (8050)
  • Scientific Communication and Education (1431)
  • Synthetic Biology (2208)
  • Systems Biology (6016)
  • Zoology (1249)