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The role of contact inhibition in intratumoral heterogeneity: An off-lattice individual based model

Jill Gallaher Jr, View ORCID ProfileAlexander R.A. Anderson
doi: https://doi.org/10.1101/036467
Jill Gallaher Jr
1Integrated Mathematical Oncology (IMO) Department, Moffitt Cancer Center, Tampa, FL 33605 USA.
Roles: ICBP Member
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Alexander R.A. Anderson
2IMO Department, Moffitt Cancer Center, Tampa, FL 33605 USA.
Roles: ICBP Member, PSOC Member
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  • ORCID record for Alexander R.A. Anderson
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Abstract

We present a model that shows how intratumoral heterogeneity, in terms of tumor cell phenotypic traits, can evolve in a tumor mass as a result of selection when space is a limited resource. This model specifically looks at the traits of proliferation rate and migration speed. The competition for space amongst individuals in the tumor mass creates a selection pressure for the cells with the fittest traits. To allow for organic movement and capture the invasive behavior, we use an off-lattice individual-based model.

Footnotes

  • e-mail: alexander.anderson{at}mofffitt.org.

  • Research supported by ICBP U54 CA113007 and PSOC U54CA143970.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted January 11, 2016.
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The role of contact inhibition in intratumoral heterogeneity: An off-lattice individual based model
Jill Gallaher Jr, Alexander R.A. Anderson
bioRxiv 036467; doi: https://doi.org/10.1101/036467
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The role of contact inhibition in intratumoral heterogeneity: An off-lattice individual based model
Jill Gallaher Jr, Alexander R.A. Anderson
bioRxiv 036467; doi: https://doi.org/10.1101/036467

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