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Cell Assembly Dynamics of Sparsely-connected Inhibitory Networks: a Simple Model for the Collective Activity of Striatal Projection Neurons

David Angulo-Garcia, Joshua D. Berke, Alessandro Torcini
doi: https://doi.org/10.1101/036608
David Angulo-Garcia
1Aix-Marseille Université, Inserm, INMED UMR 901 and Institut de Neurosciences des Systèemes UMR 1106, 13000 Marseille, France
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Joshua D. Berke
2Department of Psychology and Biomedical Engineering, University of Michigan, Ann Arbor, 530 Church St., Ann Arbor, MI 48104, USA
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Alessandro Torcini
1Aix-Marseille Université, Inserm, INMED UMR 901 and Institut de Neurosciences des Systèemes UMR 1106, 13000 Marseille, France
3CNR - Consiglio Nazionale delle Ricerche - Istituto dei Sistemi Complessi, via Madonna del Piano 10, I-50019 Sesto Fiorentino, Italy
4Aix-Marseille Université, Université de Toulon, CNRS, CPT, UMR 7332, 13288 Marseille, France
5INFN Sez. Firenze, via Sansone, 1 - I-50019 Sesto Fiorentino, Italy
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Abstract

Striatal projection neurons form a sparsely-connected inhibitory network, and this arrangement may be essential for the appropriate temporal organization of behavior. Here we show that a simplified, sparse inhibitory network of Leaky-Integrate-and-Fire neurons can reproduce some key features of striatal population activity, as observed in brain slices. In particular we develop a new metric to determine the conditions under which sparse inhibitory networks form anti-correlated cell assemblies with time-varying activity of individual cells. We find that under these conditions the network displays an input-specific sequence of cell assembly switching, that effectively discriminates similar inputs. Our results support the proposal that GABAergic connections between striatal projection neurons allow stimulus-selective, temporally-extended sequential activation of cell assemblies. Furthermore, we help to show how altered intrastriatal GABAergic signaling may produce aberrant network-level information processing in disorders such as Parkinson’s and Huntington’s diseases.

Author Summary Neuronal networks that are loosely coupled by inhibitory connections can exhibit potentially useful properties. These include the ability to produce slowly-changing activity patterns, that could be important for organizing actions and thoughts over time. The striatum is a major brain structure that is critical for appropriately timing behavior to receive rewards. Striatal projection neurons have loose inhibitory interconnections, and here we show that even a highly simplified model of this striatal network is capable of producing slowly-changing activity sequences. We examine some key parameters important for producing these dynamics, and help explain how changes in striatal connectivity may contribute to serious human disorders including Parkinson’s and Huntington’s diseases.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted January 13, 2016.
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Cell Assembly Dynamics of Sparsely-connected Inhibitory Networks: a Simple Model for the Collective Activity of Striatal Projection Neurons
David Angulo-Garcia, Joshua D. Berke, Alessandro Torcini
bioRxiv 036608; doi: https://doi.org/10.1101/036608
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Cell Assembly Dynamics of Sparsely-connected Inhibitory Networks: a Simple Model for the Collective Activity of Striatal Projection Neurons
David Angulo-Garcia, Joshua D. Berke, Alessandro Torcini
bioRxiv 036608; doi: https://doi.org/10.1101/036608

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