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Tempo and mode of genome evolution in a 50,000-generation experiment

Olivier Tenaillon, Jeffrey E. Barrick, Noah Ribeck, Daniel E. Deatherage, Jeffrey L. Blanchard, Aurko Dasgupta, Gabriel C. Wu, Sébastien Wielgoss, Stéphane Cruveiller, Claudine Médigue, Dominique Schneider, View ORCID ProfileRichard E. Lenski
doi: https://doi.org/10.1101/036806
Olivier Tenaillon
1Université Paris Diderot, IAME, UMR 1137, Sorbonne Paris Cité, F-75018 Paris, France.
2INSERM, IAME, UMR 1137, F-75018 Paris, France.
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Jeffrey E. Barrick
3Department of Molecular Biosciences, Institute for Cellular and Molecular Biology, Center for Systems and Synthetic Biology, Center for Computational Biology and Bioinformatics, The University of Texas at Austin, Austin, TX 78712, USA.
4BEACON Center for the Study of Evolution in Action, Michigan State University, East Lansing, MI 48824, USA.
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Noah Ribeck
4BEACON Center for the Study of Evolution in Action, Michigan State University, East Lansing, MI 48824, USA.
5Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA.
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Daniel E. Deatherage
3Department of Molecular Biosciences, Institute for Cellular and Molecular Biology, Center for Systems and Synthetic Biology, Center for Computational Biology and Bioinformatics, The University of Texas at Austin, Austin, TX 78712, USA.
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Jeffrey L. Blanchard
6Department of Biology, University of Massachusetts, Amherst, MA 01003, USA.
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Aurko Dasgupta
3Department of Molecular Biosciences, Institute for Cellular and Molecular Biology, Center for Systems and Synthetic Biology, Center for Computational Biology and Bioinformatics, The University of Texas at Austin, Austin, TX 78712, USA.
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Gabriel C. Wu
3Department of Molecular Biosciences, Institute for Cellular and Molecular Biology, Center for Systems and Synthetic Biology, Center for Computational Biology and Bioinformatics, The University of Texas at Austin, Austin, TX 78712, USA.
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Sébastien Wielgoss
7Institute of Integrative Biology, ETH Zürich, Universitätstrasse 16, Zürich 8092, Switzerland.
8Université Grenoble Alpes, Laboratoire Technologies de l’Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications (TIMC-IMAG), F-38000 Grenoble, France.
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Stéphane Cruveiller
9Direction des Sciences du Vivant, CEA, Institut de Génomique, Genoscope & CNRS-UMR8030, Évry, France.
10Laboratoire d’Analyses Bioinformatiques en Génomique et Métabolisme, Évry, France.
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Claudine Médigue
9Direction des Sciences du Vivant, CEA, Institut de Génomique, Genoscope & CNRS-UMR8030, Évry, France.
10Laboratoire d’Analyses Bioinformatiques en Génomique et Métabolisme, Évry, France.
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Dominique Schneider
8Université Grenoble Alpes, Laboratoire Technologies de l’Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications (TIMC-IMAG), F-38000 Grenoble, France.
11Centre National de la Recherche Scientifique, TIMC-IMAG, F-38000 Grenoble, France
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Richard E. Lenski
4BEACON Center for the Study of Evolution in Action, Michigan State University, East Lansing, MI 48824, USA.
5Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA.
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  • ORCID record for Richard E. Lenski
  • For correspondence: lenski@msu.edu
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Article Information

doi 
https://doi.org/10.1101/036806
History 
  • January 15, 2016.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Olivier Tenaillon1,2*,
  2. Jeffrey E. Barrick3,4*,
  3. Noah Ribeck4,5,
  4. Daniel E. Deatherage3,
  5. Jeffrey L. Blanchard6,
  6. Aurko Dasgupta3+,
  7. Gabriel C. Wu3,
  8. Sébastien Wielgoss7,8,
  9. Stéphane Cruveiller9,10,
  10. Claudine Médigue9,10,
  11. Dominique Schneider8,11 and
  12. Richard E. Lenski4,5*†
  1. 1Université Paris Diderot, IAME, UMR 1137, Sorbonne Paris Cité, F-75018 Paris, France.
  2. 2INSERM, IAME, UMR 1137, F-75018 Paris, France.
  3. 3Department of Molecular Biosciences, Institute for Cellular and Molecular Biology, Center for Systems and Synthetic Biology, Center for Computational Biology and Bioinformatics, The University of Texas at Austin, Austin, TX 78712, USA.
  4. 4BEACON Center for the Study of Evolution in Action, Michigan State University, East Lansing, MI 48824, USA.
  5. 5Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA.
  6. 6Department of Biology, University of Massachusetts, Amherst, MA 01003, USA.
  7. 7Institute of Integrative Biology, ETH Zürich, Universitätstrasse 16, Zürich 8092, Switzerland.
  8. 8Université Grenoble Alpes, Laboratoire Technologies de l’Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications (TIMC-IMAG), F-38000 Grenoble, France.
  9. 9Direction des Sciences du Vivant, CEA, Institut de Génomique, Genoscope & CNRS-UMR8030, Évry, France.
  10. 10Laboratoire d’Analyses Bioinformatiques en Génomique et Métabolisme, Évry, France.
  11. 11Centre National de la Recherche Scientifique, TIMC-IMAG, F-38000 Grenoble, France
  1. ↵†Corresponding author. E-mail: lenski{at}msu.edu
  1. ↵* These authors contributed equally to this work.

  • ↵+ Present address: Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

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Tempo and mode of genome evolution in a 50,000-generation experiment
Olivier Tenaillon, Jeffrey E. Barrick, Noah Ribeck, Daniel E. Deatherage, Jeffrey L. Blanchard, Aurko Dasgupta, Gabriel C. Wu, Sébastien Wielgoss, Stéphane Cruveiller, Claudine Médigue, Dominique Schneider, Richard E. Lenski
bioRxiv 036806; doi: https://doi.org/10.1101/036806
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Tempo and mode of genome evolution in a 50,000-generation experiment
Olivier Tenaillon, Jeffrey E. Barrick, Noah Ribeck, Daniel E. Deatherage, Jeffrey L. Blanchard, Aurko Dasgupta, Gabriel C. Wu, Sébastien Wielgoss, Stéphane Cruveiller, Claudine Médigue, Dominique Schneider, Richard E. Lenski
bioRxiv 036806; doi: https://doi.org/10.1101/036806

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