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Genome-wide patterns of regulatory divergence revealed by introgression lines

View ORCID ProfileRafael F. Guerrero, View ORCID ProfileAmanda L. Posto, View ORCID ProfileLeonie C. Moyle, View ORCID ProfileMatthew W. Hahn
doi: https://doi.org/10.1101/037333
Rafael F. Guerrero
1Department of Biology, Indiana University, Bloomington IN 47405, USA
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Amanda L. Posto
1Department of Biology, Indiana University, Bloomington IN 47405, USA
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Leonie C. Moyle
1Department of Biology, Indiana University, Bloomington IN 47405, USA
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Matthew W. Hahn
1Department of Biology, Indiana University, Bloomington IN 47405, USA
2School of Informatics and Computing, Indiana University, Bloomington IN 47405, USA
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Abstract

Understanding the genetic basis for changes in transcriptional regulation is an important aspect of understanding phenotypic evolution. Using interspecific introgression lines, we infer the mechanisms of divergence in genome-wide patterns of gene expression between the nightshades Solanum pennellii and S. lycopersicum (domesticated tomato). We find that cis- and frans-regulatory changes have had qualitatively similar contributions to divergence in this clade, unlike results from other systems. Additionally, expression data from four tissues (shoot apex, ripe fruit, pollen, and seed) suggest that introgressed regions in these hybrid lines tend to be down-regulated, while background (non-introgressed) genes tend to be up-regulated. Finally, we find no evidence for an association between the magnitude of differential expression in NILs and previously determined sterility phenotypes. Our results contradict previous predictions of the predominant role of cis- over frans-regulatory divergence between species, and do not support a major role for gross genome-wide misregulation in reproductive isolation between these species.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted January 19, 2016.
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Genome-wide patterns of regulatory divergence revealed by introgression lines
Rafael F. Guerrero, Amanda L. Posto, Leonie C. Moyle, Matthew W. Hahn
bioRxiv 037333; doi: https://doi.org/10.1101/037333
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Genome-wide patterns of regulatory divergence revealed by introgression lines
Rafael F. Guerrero, Amanda L. Posto, Leonie C. Moyle, Matthew W. Hahn
bioRxiv 037333; doi: https://doi.org/10.1101/037333

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