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IRNdb: The database of immunologically relevant non-coding RNAs

Elena Denisenko, Daniel Ho, Ousman Tamgue, Mumin Ozturk, Harukazu Suzuki, Frank Brombacher, Reto Guler, View ORCID ProfileSebastian Schmeier
doi: https://doi.org/10.1101/037911
Elena Denisenko
1Massey University, Institute of Natural and Mathematical Sciences, 0632 Albany, Auckland, New Zealand
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Daniel Ho
1Massey University, Institute of Natural and Mathematical Sciences, 0632 Albany, Auckland, New Zealand
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Ousman Tamgue
2International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component, Cape Town, South Africa
3University of Cape Town, Health Science Faculty, Institute of Infectious Diseases and Molecular Medicine (IDM), Division of Immunology, Cape Town, South Africa
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Mumin Ozturk
2International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component, Cape Town, South Africa
3University of Cape Town, Health Science Faculty, Institute of Infectious Diseases and Molecular Medicine (IDM), Division of Immunology, Cape Town, South Africa
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Harukazu Suzuki
4Division of Genomic Technologies, RIKEN Center for Life Science Technologies, 1-7-22 Suehirocho, Tsurumi-ku, Yokohama 230-0045, Japan
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Frank Brombacher
2International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component, Cape Town, South Africa
3University of Cape Town, Health Science Faculty, Institute of Infectious Diseases and Molecular Medicine (IDM), Division of Immunology, Cape Town, South Africa
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Reto Guler
2International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component, Cape Town, South Africa
3University of Cape Town, Health Science Faculty, Institute of Infectious Diseases and Molecular Medicine (IDM), Division of Immunology, Cape Town, South Africa
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Sebastian Schmeier
1Massey University, Institute of Natural and Mathematical Sciences, 0632 Albany, Auckland, New Zealand
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  • ORCID record for Sebastian Schmeier
  • For correspondence: s.schmeier@massey.ac.nz
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Abstract

MicroRNAs (miRNAs), long non-coding RNAs (lncRNAs) and other functional non-coding RNAs (ncRNAs) have emerged as pivotal regulators involved in multiple biological processes. Recently, ncRNA control of gene expression has been identified as a critical regulatory mechanism in the immune system. Despite the great efforts made to discover and characterize ncRNAs, the functional role for most remains unknown. To facilitate discoveries in ncRNA regulation of immune system-related processes we developed the database of immunologically relevant ncRNAs and target genes (IRNdb). We integrated mouse data on predicted and experimentally supported ncRNA-target interactions, ncRNA and gene annotations, biological pathways and processes, and experimental data in a uniform format with a user-friendly web interface. The current version of IRNdb documents 12,930 experimentally supported miRNA-target interactions between 724 miRNAs and 2,427 immune-related murine targets. In addition, we recorded 22,453 lncRNA-immune target and 377 PIWI-interacting RNA-immune target interactions. IRNdb is a comprehensive searchable data repository which will be of help in studying the role of ncRNAs in the immune system.

Database URL: http://irndb.org

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Posted September 25, 2016.
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IRNdb: The database of immunologically relevant non-coding RNAs
Elena Denisenko, Daniel Ho, Ousman Tamgue, Mumin Ozturk, Harukazu Suzuki, Frank Brombacher, Reto Guler, Sebastian Schmeier
bioRxiv 037911; doi: https://doi.org/10.1101/037911
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IRNdb: The database of immunologically relevant non-coding RNAs
Elena Denisenko, Daniel Ho, Ousman Tamgue, Mumin Ozturk, Harukazu Suzuki, Frank Brombacher, Reto Guler, Sebastian Schmeier
bioRxiv 037911; doi: https://doi.org/10.1101/037911

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