Abstract
Nitric oxide performs a wide variety of versatile functions in the immune system. The precise role of nitric oxide in pathogenesis of acute inflammation and sepsis is still controversial. A direct physical interaction between inducible nitric oxide synthase (iNOS) and Nitric oxide synthase interacting protein (NOSIP) was observed that regulates Nitric Oxide production by human monocytes. A novel mutation in nitric oxide synthase interacting protein (NOSIP) determines NO levels and influence adverse prognosis and mortality in human sepsis. Differences in production of Nitric oxide by murine and human macrophages could be attributed to differential expression of NOSIP by the two species. The study reveals NOSIP as an important regulator of inflammation by virtue of its ability to influence nitric oxide production which inhibits IL-lβ levels in both mice and in humans and opens up novel avenues for therapeutic strategies against acute inflammation.