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A tradeoff between the ecological and evolutionary stabilities of public goods genes in microbial populations

Joseph Rauch, Jane Kondev, Alvaro Sanchez
doi: https://doi.org/10.1101/039784
Joseph Rauch
1Department of Physics and Howard Hughes Medical Institute, Brandeis University, 405 South Street, Waltham, MA 02542
2The Rowland Institute, Harvard University, 100 Edwin Land Blvd, Cambridge MA 02142
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  • For correspondence: jwrauch@brandeis.edu sanchez@rowland.harvard.edu
Jane Kondev
1Department of Physics and Howard Hughes Medical Institute, Brandeis University, 405 South Street, Waltham, MA 02542
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Alvaro Sanchez
2The Rowland Institute, Harvard University, 100 Edwin Land Blvd, Cambridge MA 02142
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  • For correspondence: jwrauch@brandeis.edu sanchez@rowland.harvard.edu
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Abstract

Microbial populations often rely on the cooperative production of extracellular “public goods” molecules. The cooperative nature of public good production may lead to minimum viable population sizes, below which populations collapse. In addition, “cooperator” public goods producing cells face evolutionary competition from non-producing mutants, or “freeloaders”. Thus, public goods cooperators have to be stable not only to the invasion of freeloaders, but also to ecological perturbations that may push their numbers too small to be sustainable. Through a combination of experiments with microbial populations and mathematical analysis of the Ecological Public Goods Game, we show that game parameters and experimental conditions that improve the evolutionary stability of cooperators also lead to a low ecological stability of the cooperator population. Complex regulatory strategies mimicking those used by microbes in nature may allow cooperators to beat this eco-evolutionary stability tradeoff and become resistant to freeloaders while at the same time maximizing their ecological stability. Our results thus identify the coupled eco-evolutionary stability as being key for the long-term viability of microbial public goods cooperators.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted February 15, 2016.
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A tradeoff between the ecological and evolutionary stabilities of public goods genes in microbial populations
Joseph Rauch, Jane Kondev, Alvaro Sanchez
bioRxiv 039784; doi: https://doi.org/10.1101/039784
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A tradeoff between the ecological and evolutionary stabilities of public goods genes in microbial populations
Joseph Rauch, Jane Kondev, Alvaro Sanchez
bioRxiv 039784; doi: https://doi.org/10.1101/039784

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