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Enabling the democratization of the genomics revolution with a fully integrated web-based bioinformatics platform

Po-E Li, Chien-Chi Lo, Joseph J. Anderson, Karen W. Davenport, Kimberly A. Bishop-Lilly, Yan Xu, Sanaa Ahmed, Shihai Feng, Vishwesh P. Mokashi, Patrick S. G. Chain
doi: https://doi.org/10.1101/040477
Po-E Li
1Biome Sciences, Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87545
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Chien-Chi Lo
1Biome Sciences, Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87545
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Joseph J. Anderson
2Defense Threat Reduction Agency, Fort Belvoir, VA
3Naval Medical Research Center – Frederick, Fort Detrick, MD 21702
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Karen W. Davenport
1Biome Sciences, Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87545
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Kimberly A. Bishop-Lilly
3Naval Medical Research Center – Frederick, Fort Detrick, MD 21702
4Henry M. Jackson Foundation, Bethesda, MD 20817
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Yan Xu
1Biome Sciences, Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87545
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Sanaa Ahmed
1Biome Sciences, Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87545
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Shihai Feng
1Biome Sciences, Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87545
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Vishwesh P. Mokashi
3Naval Medical Research Center – Frederick, Fort Detrick, MD 21702
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Patrick S. G. Chain
1Biome Sciences, Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87545
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ABSTRACT

Continued advancements in sequencing technologies have fueled the development of new sequencing applications and promise to flood current databases with raw data. A number of factors prevent the seamless and easy use of these data, including the breadth of project goals, the wide array of tools that individually perform fractions of any given analysis, the large number of associated software/hardware dependencies, and the detailed expertise required to perform these analyses. To address these issues, we have developed an intuitive web-based environment with a wide assortment of integrated and cutting-edge bioinformatics tools. These preconfigured workflows provide even novice next-generation sequencing users with the ability to perform many complex analyses with only a few mouse clicks, and, within the context of the same environment, to visualize and further interrogate their results. This bioinformatics platform is an initial attempt at Empowering the Development of Genomics Expertise (EDGE) in a wide range of applications.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted February 21, 2016.
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Enabling the democratization of the genomics revolution with a fully integrated web-based bioinformatics platform
Po-E Li, Chien-Chi Lo, Joseph J. Anderson, Karen W. Davenport, Kimberly A. Bishop-Lilly, Yan Xu, Sanaa Ahmed, Shihai Feng, Vishwesh P. Mokashi, Patrick S. G. Chain
bioRxiv 040477; doi: https://doi.org/10.1101/040477
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Enabling the democratization of the genomics revolution with a fully integrated web-based bioinformatics platform
Po-E Li, Chien-Chi Lo, Joseph J. Anderson, Karen W. Davenport, Kimberly A. Bishop-Lilly, Yan Xu, Sanaa Ahmed, Shihai Feng, Vishwesh P. Mokashi, Patrick S. G. Chain
bioRxiv 040477; doi: https://doi.org/10.1101/040477

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