Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Balanced excitation and inhibition decorrelates visual feature representation in the mammalian inner retina

Katrin Franke, Philipp Berens, Timm Schubert, Matthias Bethge, Thomas Euler, View ORCID ProfileTom Baden
doi: https://doi.org/10.1101/040642
Katrin Franke
1Centre for Integrative Neuroscience, University of Tübingen, Germany.
4Graduate School of Neural & Behavioural Sciences ∣ International Max Planck Research School, University of Tübingen, Germany.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Philipp Berens
1Centre for Integrative Neuroscience, University of Tübingen, Germany.
3Institute for Ophthalmic Research, Tübingen, Germany.
5Institute for Theoretical Physics, University of Tübingen, Germany.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Timm Schubert
1Centre for Integrative Neuroscience, University of Tübingen, Germany.
3Institute for Ophthalmic Research, Tübingen, Germany.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Matthias Bethge
1Centre for Integrative Neuroscience, University of Tübingen, Germany.
2Bernstein Centre for Computational Neuroscience, Tübingen, Germany.
5Institute for Theoretical Physics, University of Tübingen, Germany.
6Max Planck Institute of Biological Cybernetics, Tübingen, Germany.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thomas Euler
1Centre for Integrative Neuroscience, University of Tübingen, Germany.
3Institute for Ophthalmic Research, Tübingen, Germany.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: thomas.euler@cin.uni-tuebingen.de tom@badenlab.org
Tom Baden
1Centre for Integrative Neuroscience, University of Tübingen, Germany.
3Institute for Ophthalmic Research, Tübingen, Germany.
7School of Life Sciences, University of Sussex, Brighton, UK.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Tom Baden
  • For correspondence: thomas.euler@cin.uni-tuebingen.de tom@badenlab.org
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

SUMMARY

The retina extracts visual features for transmission to the brain. Different types of bipolar cell split the photoreceptor input into parallel channels and provide the excitatory drive for downstream visual circuits. Anatomically, mouse bipolar cell types have been described down to the ultrastructural level, but a similarly deep understanding of their functional diversity is lacking. By imaging light-driven glutamate release from more than 11,000 bipolar cell axon terminals in the intact retina, we here show that bipolar cell functional diversity is generated by the balanced interplay of dendritic excitatory inputs and axonal inhibitory inputs. The resultant centre and surround components of bipolar cell receptive fields interact to decorrelate bipolar cell output in the spatial and temporal domain. Our findings highlight the importance of inhibitory circuits in generating functionally diverse excitatory pathways and suggest that decorrelation of parallel visual pathways begins already at the second synapse of the mouse visual system.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted March 22, 2016.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Balanced excitation and inhibition decorrelates visual feature representation in the mammalian inner retina
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Balanced excitation and inhibition decorrelates visual feature representation in the mammalian inner retina
Katrin Franke, Philipp Berens, Timm Schubert, Matthias Bethge, Thomas Euler, Tom Baden
bioRxiv 040642; doi: https://doi.org/10.1101/040642
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
Balanced excitation and inhibition decorrelates visual feature representation in the mammalian inner retina
Katrin Franke, Philipp Berens, Timm Schubert, Matthias Bethge, Thomas Euler, Tom Baden
bioRxiv 040642; doi: https://doi.org/10.1101/040642

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (4113)
  • Biochemistry (8815)
  • Bioengineering (6518)
  • Bioinformatics (23460)
  • Biophysics (11789)
  • Cancer Biology (9207)
  • Cell Biology (13322)
  • Clinical Trials (138)
  • Developmental Biology (7436)
  • Ecology (11409)
  • Epidemiology (2066)
  • Evolutionary Biology (15150)
  • Genetics (10436)
  • Genomics (14043)
  • Immunology (9171)
  • Microbiology (22153)
  • Molecular Biology (8812)
  • Neuroscience (47567)
  • Paleontology (350)
  • Pathology (1428)
  • Pharmacology and Toxicology (2491)
  • Physiology (3730)
  • Plant Biology (8079)
  • Scientific Communication and Education (1437)
  • Synthetic Biology (2221)
  • Systems Biology (6037)
  • Zoology (1253)