Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle

Ruzbeh Mosadeghi; Kurt M. Reichermeier; Martin Winkler; Anne Schreiber; Justin M. Reitsma; Yaru Zhang; Florian Stengel; Junyue Cao; Minsoo Kim; Michael J. Sweredoski; Sonja Hess; Alexander Leitner; Ruedi Aebersold; Matthias Peter; Raymond J. Deshaies; Radoslav I. Enchev

doi:10.1101/046367

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Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle

Ruzbeh Mosadeghi, Kurt M. Reichermeier, Martin Winkler, Anne Schreiber, Justin M. Reitsma, Yaru Zhang, Florian Stengel, Junyue Cao, Minsoo Kim, Michael J. Sweredoski, Sonja Hess, Alexander Leitner, Ruedi Aebersold, Matthias Peter, Raymond J. Deshaies, Radoslav I. Enchev

doi: https://doi.org/10.1101/046367

Ruzbeh Mosadeghi

1Keck School of Medicine of the University of Southern California/California Institute of Technology Combined MD/PhD Program

2Division of Biology and Biological Engineering, California Institute of Technology, Pasadena CA, USA, 911250

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Kurt M. Reichermeier

2Division of Biology and Biological Engineering, California Institute of Technology, Pasadena CA, USA, 911250

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Martin Winkler

3Department of Biology, Institute of Biochemistry, Swiss Federal Institute of Technology, Otto-Stern Weg 3, 8093 Zürich, Switzerland

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Anne Schreiber

3Department of Biology, Institute of Biochemistry, Swiss Federal Institute of Technology, Otto-Stern Weg 3, 8093 Zürich, Switzerland

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Justin M. Reitsma

2Division of Biology and Biological Engineering, California Institute of Technology, Pasadena CA, USA, 911250

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Yaru Zhang

2Division of Biology and Biological Engineering, California Institute of Technology, Pasadena CA, USA, 911250

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Florian Stengel

4Department of Biology, Institute of Molecular Systems Biology, Swiss Federal Institute of Technology, HPT E 78, August-Piccard-Hof 1, 8093 Zürich, Switzerland

8Current Address - Department of Biology, University of Konstanz, 78457 Konstanz, Germany

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Junyue Cao

2Division of Biology and Biological Engineering, California Institute of Technology, Pasadena CA, USA, 911250

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Minsoo Kim

2Division of Biology and Biological Engineering, California Institute of Technology, Pasadena CA, USA, 911250

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Michael J. Sweredoski

5Proteome Exploration Lab, Beckman Institute, California Institute of Technology, Pasadena CA, USA, 91125

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Sonja Hess

5Proteome Exploration Lab, Beckman Institute, California Institute of Technology, Pasadena CA, USA, 91125

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Alexander Leitner

4Department of Biology, Institute of Molecular Systems Biology, Swiss Federal Institute of Technology, HPT E 78, August-Piccard-Hof 1, 8093 Zürich, Switzerland

8Current Address - Department of Biology, University of Konstanz, 78457 Konstanz, Germany

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Ruedi Aebersold

4Department of Biology, Institute of Molecular Systems Biology, Swiss Federal Institute of Technology, HPT E 78, August-Piccard-Hof 1, 8093 Zürich, Switzerland

6Faculty of Science, University of Zurich, Zurich, Switzerland

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Matthias Peter

3Department of Biology, Institute of Biochemistry, Swiss Federal Institute of Technology, Otto-Stern Weg 3, 8093 Zürich, Switzerland

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Raymond J. Deshaies

2Division of Biology and Biological Engineering, California Institute of Technology, Pasadena CA, USA, 911250

7Howard Hughes Medical Institute

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Radoslav I. Enchev

3Department of Biology, Institute of Biochemistry, Swiss Federal Institute of Technology, Otto-Stern Weg 3, 8093 Zürich, Switzerland

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