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Carriers of human mitochondrial DNA macrohaplogroup M colonized India from southeastern Asia

Patricia Marrero, Khaled K. Abu-Amero, Jose M Larruga, Vicente M Cabrera
doi: https://doi.org/10.1101/047456
Patricia Marrero
aSchool of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, Norfolk, England;
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Khaled K. Abu-Amero
bGlaucoma Research Chair, Department of Ophthalmology, College of Medicine, King Saud University; Riyadh, Saudi Arabia.
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Jose M Larruga
cDepartamento de Genetica, Universidad de La Laguna, La Laguna, Tenerife, Spain
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Vicente M Cabrera
cDepartamento de Genetica, Universidad de La Laguna, La Laguna, Tenerife, Spain
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  • For correspondence: vicente.vca811@gmail.com
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ABSTRACT

Objetives We suggest that the phylogeny and phylogeography of mtDNA macrohaplogroup M in Eurasia and Australasia is better explained supposing an out of Africa of modern humans following a northern route across the Levant than the most prevalent southern coastal route across Arabia and India proposed by others.

Methods A total 206 Saudi samples belonging to macrohaplogroup M have been analyzed. In addition, 4107 published complete or nearly complete Eurasian and Australasian mtDNA genomes ascribed to the same macrohaplogroup have been included in a global phylogeographic analysis.

Results Macrohaplogroup M has only historical implantation in West Eurasia including the Arabian Peninsula. Founder ages of M lineages in India are significantly younger than those in East Asia, Southeast Asia and Near Oceania. These results point to a colonization of the Indian subcontinent by modern humans carrying M lineages from the east instead the west side.

Conclusions The existence of a northern route previously advanced by the phylogeography of mtDNA macrohaplogroup N is confirmed here by that of macrohaplogroup M. Taking this genetic evidence and those reported by other disciplines we have constructed a new and more conciliatory model to explain the history of modern humans out of Africa.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted April 06, 2016.
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Carriers of human mitochondrial DNA macrohaplogroup M colonized India from southeastern Asia
Patricia Marrero, Khaled K. Abu-Amero, Jose M Larruga, Vicente M Cabrera
bioRxiv 047456; doi: https://doi.org/10.1101/047456
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Carriers of human mitochondrial DNA macrohaplogroup M colonized India from southeastern Asia
Patricia Marrero, Khaled K. Abu-Amero, Jose M Larruga, Vicente M Cabrera
bioRxiv 047456; doi: https://doi.org/10.1101/047456

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