Wild-type U2AF1 antagonizes the splicing program characteristic of U2AF1-mutant tumors and is required for cell survival

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Dennis Liang Fei, Hayley Motowski, Rakesh Chatrikhi, Sameer Prasad, Jovian Yu, Shaojian Gao, Clara Kielkopf, Robert K. Bradley, Harold Varmus

doi: https://doi.org/10.1101/048553

Dennis Liang Fei

1Cancer Biology Section, Cancer Genetics Branch, National Human Genome Research Institute, Bethesda, MD 20892, United States

2Department of Medicine, Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, United States

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For correspondence: dlf2002@med.cornell.edu clara_kielkopf@urmc.rochester.edu rbradley@fredhutch.org varmus@med.cornell.edu

Hayley Motowski

1Cancer Biology Section, Cancer Genetics Branch, National Human Genome Research Institute, Bethesda, MD 20892, United States

Rakesh Chatrikhi

3Department of Biochemistry and Biophysics, Center for RNA Biology, University of Rochester Medical Center, Rochester, NY 14642, United States

Sameer Prasad

1Cancer Biology Section, Cancer Genetics Branch, National Human Genome Research Institute, Bethesda, MD 20892, United States

Jovian Yu

1Cancer Biology Section, Cancer Genetics Branch, National Human Genome Research Institute, Bethesda, MD 20892, United States

Shaojian Gao

4Genetics Branch, National Cancer Institute, Bethesda, Maryland, 20892, United States

Clara Kielkopf

3Department of Biochemistry and Biophysics, Center for RNA Biology, University of Rochester Medical Center, Rochester, NY 14642, United States

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For correspondence: dlf2002@med.cornell.edu clara_kielkopf@urmc.rochester.edu rbradley@fredhutch.org varmus@med.cornell.edu

Robert K. Bradley

5Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, United States

6Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, United States

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For correspondence: dlf2002@med.cornell.edu clara_kielkopf@urmc.rochester.edu rbradley@fredhutch.org varmus@med.cornell.edu

Harold Varmus

1Cancer Biology Section, Cancer Genetics Branch, National Human Genome Research Institute, Bethesda, MD 20892, United States

2Department of Medicine, Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, United States

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For correspondence: dlf2002@med.cornell.edu clara_kielkopf@urmc.rochester.edu rbradley@fredhutch.org varmus@med.cornell.edu