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Heat*seq: an interactive web tool for high-throughput sequencing experiment comparison with public data

View ORCID ProfileGuillaume Devailly, View ORCID ProfileAnna Mantsoki, Anagha Joshi
doi: https://doi.org/10.1101/049254
Guillaume Devailly
1Department of Developmental Biology, The Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian EH25 9RG, United Kingdom.
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Anna Mantsoki
1Department of Developmental Biology, The Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian EH25 9RG, United Kingdom.
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Anagha Joshi
1Department of Developmental Biology, The Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian EH25 9RG, United Kingdom.
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Abstract

Summary Better protocols and decreasing costs have made high-throughput sequencing experiments now accessible even to small experimental laboratories. However, comparing one or few experiments generated by an individual lab to the vast amount of relevant data freely available in the public domain might be limited due to lack of bioinformatics expertise. Though several tools, including genome browsers, allow such comparison at a single gene level, they do not provide a genome-wide view. We developed Heat*seq, a web-tool that allows genome scale comparison of high throughput experiments (ChIP-seq, RNA-seq and CAGE) provided by a user, to the data in the public domain. Heat*seq currently contains over 12,000 experiments across diverse tissue and cell types in human, mouse and drosophila. Heat*seq displays interactive correlation heatmaps, with an ability to dynamically subset datasets to contextualise user experiments. High quality figures and tables are produced and can be downloaded in multiple formats.

Availability Web application: http://www.heatstarseq.roslin.ed.ac.uk/. Source code: https://github.com/gdevailly.

Contact Guillaume.Devailly{at}roslin.ed.ac.uk; Anagha.Joshi{at}roslin.ed.ac.uk

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted April 18, 2016.
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Heat*seq: an interactive web tool for high-throughput sequencing experiment comparison with public data
Guillaume Devailly, Anna Mantsoki, Anagha Joshi
bioRxiv 049254; doi: https://doi.org/10.1101/049254
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Heat*seq: an interactive web tool for high-throughput sequencing experiment comparison with public data
Guillaume Devailly, Anna Mantsoki, Anagha Joshi
bioRxiv 049254; doi: https://doi.org/10.1101/049254

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