New Results
Ultra-rare disruptive and damaging mutations influence educational attainment in the general population
Andrea Ganna, Giulio Genovese, Daniel P. Howrigan, Andrea Byrnes, Mitja Kurki, Seyedeh M. Zekavat, Christopher W. Whelan, Mart Kals, Michel G. Nivard, Alex Bloemendal, Jonathan M. Bloom, Jacqueline I. Goldstein, Timothy Poterba, Cotton Seed, Robert E. Handsaker, Pradeep Natarajan, Reedik Mägi, Diane Gage, Elise B. Robinson, Andres Metspalu, Veikko Salomaa, Jaana Suvisaari, Shaun M. Purcell, Pamela Sklar, Sekar Kathiresan, Mark J. Daly, Steven A. McCarroll, Patrick F. Sullivan, Aarno Palotie, Tõnu Esko, Christina Hultman, Benjamin M. Neale
doi: https://doi.org/10.1101/050195
Andrea Ganna
1Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston02114, MA, USA
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
3Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
4Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 171 77, Sweden
Giulio Genovese
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
3Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
5Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Daniel P. Howrigan
1Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston02114, MA, USA
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
3Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Andrea Byrnes
1Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston02114, MA, USA
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
3Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Mitja Kurki
1Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston02114, MA, USA
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
3Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
6Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki FI-00014, Finland
Seyedeh M. Zekavat
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
7Center for Human Genetic Research and Cardiovascular Research Center,Massachusetts General Hospital, Boston, MA, 02114, USA
8Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA
Christopher W. Whelan
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
3Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
5Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Mart Kals
9Estonian Genome Center, University of Tartu, Tartu 51010, Estonia
10Institute of Mathematics and Statistics, University of Tartu, Tartu 50409, Estonia
Michel G. Nivard
11Department of Biological Psychology, VU University Amsterdam, Amsterdam 1081 HV, The Netherlands
Alex Bloemendal
1Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston02114, MA, USA
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
3Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Jonathan M. Bloom
1Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston02114, MA, USA
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
3Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
12Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA02139, USA
Jacqueline I. Goldstein
1Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston02114, MA, USA
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
3Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Timothy Poterba
1Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston02114, MA, USA
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
3Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Cotton Seed
1Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston02114, MA, USA
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
3Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Robert E. Handsaker
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
3Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
5Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Pradeep Natarajan
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
7Center for Human Genetic Research and Cardiovascular Research Center,Massachusetts General Hospital, Boston, MA, 02114, USA
Reedik Mägi
9Estonian Genome Center, University of Tartu, Tartu 51010, Estonia
Diane Gage
3Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Elise B. Robinson
1Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston02114, MA, USA
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
3Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Andres Metspalu
9Estonian Genome Center, University of Tartu, Tartu 51010, Estonia
Veikko Salomaa
13Department of Health, THL-National Institute for Health and Welfare, Helsinki FI-00271, Finland
Jaana Suvisaari
13Department of Health, THL-National Institute for Health and Welfare, Helsinki FI-00271, Finland
Shaun M. Purcell
14Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA
15Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA
Pamela Sklar
14Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA
15Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA
Sekar Kathiresan
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
7Center for Human Genetic Research and Cardiovascular Research Center,Massachusetts General Hospital, Boston, MA, 02114, USA
Mark J. Daly
1Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston02114, MA, USA
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
3Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Steven A. McCarroll
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
3Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
5Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Patrick F. Sullivan
4Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 171 77, Sweden
16Departments of Genetics and Psychiatry, University of North Carolina, Chapel Hill,North Carolina 27599-7264USA
Aarno Palotie
1Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston02114, MA, USA
3Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
6Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki FI-00014, Finland
Tõnu Esko
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
9Estonian Genome Center, University of Tartu, Tartu 51010, Estonia
Christina Hultman
4Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 171 77, Sweden
Benjamin M. Neale
1Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston02114, MA, USA
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
3Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Posted June 07, 2016.
Ultra-rare disruptive and damaging mutations influence educational attainment in the general population
Andrea Ganna, Giulio Genovese, Daniel P. Howrigan, Andrea Byrnes, Mitja Kurki, Seyedeh M. Zekavat, Christopher W. Whelan, Mart Kals, Michel G. Nivard, Alex Bloemendal, Jonathan M. Bloom, Jacqueline I. Goldstein, Timothy Poterba, Cotton Seed, Robert E. Handsaker, Pradeep Natarajan, Reedik Mägi, Diane Gage, Elise B. Robinson, Andres Metspalu, Veikko Salomaa, Jaana Suvisaari, Shaun M. Purcell, Pamela Sklar, Sekar Kathiresan, Mark J. Daly, Steven A. McCarroll, Patrick F. Sullivan, Aarno Palotie, Tõnu Esko, Christina Hultman, Benjamin M. Neale
bioRxiv 050195; doi: https://doi.org/10.1101/050195
Ultra-rare disruptive and damaging mutations influence educational attainment in the general population
Andrea Ganna, Giulio Genovese, Daniel P. Howrigan, Andrea Byrnes, Mitja Kurki, Seyedeh M. Zekavat, Christopher W. Whelan, Mart Kals, Michel G. Nivard, Alex Bloemendal, Jonathan M. Bloom, Jacqueline I. Goldstein, Timothy Poterba, Cotton Seed, Robert E. Handsaker, Pradeep Natarajan, Reedik Mägi, Diane Gage, Elise B. Robinson, Andres Metspalu, Veikko Salomaa, Jaana Suvisaari, Shaun M. Purcell, Pamela Sklar, Sekar Kathiresan, Mark J. Daly, Steven A. McCarroll, Patrick F. Sullivan, Aarno Palotie, Tõnu Esko, Christina Hultman, Benjamin M. Neale
bioRxiv 050195; doi: https://doi.org/10.1101/050195
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