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C19ORF66 is an Interferon-Stimulated Gene (ISG) which Inhibits Human Immunodeficiency Virus-1

Weidong Xiong, Deisy Contreras, Joseph Ignatius Irudayam, Ayub Ali, Otto O. Yang, View ORCID ProfileVaithilingaraja Arumugaswami
doi: https://doi.org/10.1101/050310
Weidong Xiong
1Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048,
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Deisy Contreras
1Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048,
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Joseph Ignatius Irudayam
1Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048,
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Ayub Ali
2Departments of Medicine and Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles CA 90095.
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Otto O. Yang
2Departments of Medicine and Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles CA 90095.
3AIDS Healthcare Foundation, Los Angeles, CA 90028
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Vaithilingaraja Arumugaswami
1Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048,
4Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048,
5Department of Surgery, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles CA 90095.
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  • ORCID record for Vaithilingaraja Arumugaswami
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ABSTRACT

Innate immunity is the first line of defense against invading microbes1. The type I interferon (IFN) pathway plays a key role in controlling Human Immunodeficiency Virus type 1 (HIV-1) replication2,3. We identified an IFN-α stimulated gene C19ORF66 that we term Suppressor of Viral Activity (SVA). Full length SVA-1 protein inhibits HIV-1 by blocking virion production. SVA splice variants truncated at the C-terminus and/or disrupted at the nuclear export signal (NES) lose antiviral activity and localize to nucleus, while full length SVA-1 co-localizes with HIV-1 p24 protein in the cytoplasmic compartment of infected cells. SVA-1 is structurally and functionally conserved across species, including mouse and chimpanzee. We provide the first description of the effector function of the gene SVA/C190RF66 as an innate immune factor with anti-HIV-1 activity.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted April 26, 2016.
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C19ORF66 is an Interferon-Stimulated Gene (ISG) which Inhibits Human Immunodeficiency Virus-1
Weidong Xiong, Deisy Contreras, Joseph Ignatius Irudayam, Ayub Ali, Otto O. Yang, Vaithilingaraja Arumugaswami
bioRxiv 050310; doi: https://doi.org/10.1101/050310
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C19ORF66 is an Interferon-Stimulated Gene (ISG) which Inhibits Human Immunodeficiency Virus-1
Weidong Xiong, Deisy Contreras, Joseph Ignatius Irudayam, Ayub Ali, Otto O. Yang, Vaithilingaraja Arumugaswami
bioRxiv 050310; doi: https://doi.org/10.1101/050310

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