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The Effects of Personal Pharmacogenetic Testing on the Effects of Pharmacy Student Perceptions of Knowledge and Attitudes Towards Precision Medicine

Dalga Surofchy, Sam S. Oh, Joshua Galanter, Pin Xiang, Megan Li, Su Guo, Tejal Desai, Joseph B. Guglielmo, Kathy Giacomini, Janel Long-Boyle, Alan HB Wu, Esteban G Burchard
doi: https://doi.org/10.1101/052043
Dalga Surofchy
aSchool of Pharmacy, University of California, San Francisco
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Sam S. Oh
bDepartment of Medicine, University of California, San Francisco
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Joshua Galanter
bDepartment of Medicine, University of California, San Francisco
cDepartment of Bioengineering & Therapeutic Sciences, University of California, San Francisco
dDepartment of Epidemiology and Biostatistics, University of California, San Francisco
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Pin Xiang
aSchool of Pharmacy, University of California, San Francisco
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Megan Li
cDepartment of Bioengineering & Therapeutic Sciences, University of California, San Francisco
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Su Guo
aSchool of Pharmacy, University of California, San Francisco
cDepartment of Bioengineering & Therapeutic Sciences, University of California, San Francisco
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Tejal Desai
aSchool of Pharmacy, University of California, San Francisco
cDepartment of Bioengineering & Therapeutic Sciences, University of California, San Francisco
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Joseph B. Guglielmo
aSchool of Pharmacy, University of California, San Francisco
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Kathy Giacomini
aSchool of Pharmacy, University of California, San Francisco
cDepartment of Bioengineering & Therapeutic Sciences, University of California, San Francisco
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Janel Long-Boyle
eDepartment of Clinical Pharmacy, University of California, San Francisco
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Alan HB Wu
fDepartment of Laboratory Medicine, University of California, San Francisco
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Esteban G Burchard
aSchool of Pharmacy, University of California, San Francisco
cDepartment of Bioengineering & Therapeutic Sciences, University of California, San Francisco
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ABSTRACT

Objective To evaluate if pharmacy students’ participation in personal pharmacogenetic (Pgx) testing enhances their knowledge and attitude towards precision medicine (PM).

Methods First-year pharmacy students were offered personalized pharmacogenetic testing as a supplement to a required curricular pharmacogenomics course. Ninety-eight of 122 (80%) students completed pre- and post-course surveys assessing knowledge and attitudes regarding PM; 73 students also volunteered for personal pharmacogenetic testing of the following drug metabolizing enzymes (CYP2C19, CYP2D6, UGT1A1) and pharmacodynamics-relevant proteins (interleukin (IL)-28B & human lymphocyte antigen HLAB*5701).

Results Among the 122 students, we found that incorporating pharmacogenetic testing improved mean knowledge and attitude by 1.0 and 0.3 Likert points, respectively. We observed statistically significant improvements in 100% of knowledge and 70% of attitude-related statements for students who decided to undergo personal pharmacogenetic testing. Students who were enrolled in the course but did not partake in personalized pharmacogenetic testing had similar gains in knowledge and attitude.

Conclusion This study demonstrates the feasibility and importance of educating future pharmacists by incorporating pharmacogenetic testing into professional school curricula. Students who opt not to participate in genotyping may still benefit by learning vicariously through the shared learning environment created by genotyped students.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted December 22, 2016.
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The Effects of Personal Pharmacogenetic Testing on the Effects of Pharmacy Student Perceptions of Knowledge and Attitudes Towards Precision Medicine
Dalga Surofchy, Sam S. Oh, Joshua Galanter, Pin Xiang, Megan Li, Su Guo, Tejal Desai, Joseph B. Guglielmo, Kathy Giacomini, Janel Long-Boyle, Alan HB Wu, Esteban G Burchard
bioRxiv 052043; doi: https://doi.org/10.1101/052043
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The Effects of Personal Pharmacogenetic Testing on the Effects of Pharmacy Student Perceptions of Knowledge and Attitudes Towards Precision Medicine
Dalga Surofchy, Sam S. Oh, Joshua Galanter, Pin Xiang, Megan Li, Su Guo, Tejal Desai, Joseph B. Guglielmo, Kathy Giacomini, Janel Long-Boyle, Alan HB Wu, Esteban G Burchard
bioRxiv 052043; doi: https://doi.org/10.1101/052043

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