Shared effect modeling reveals that a fraction of autoimmune disease associations are consistent with eQTLs in three immune cell types

Sung Chun; Alexandra Casparino; Nikolaos A Patsopoulos; Damien Croteau-Chonka; Benjamin A Raby; Philip L De Jager; Shamil R Sunyaev; Chris Cotsapas

doi:10.1101/053165

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Shared effect modeling reveals that a fraction of autoimmune disease associations are consistent with eQTLs in three immune cell types

Sung Chun, Alexandra Casparino, View ORCID ProfileNikolaos A Patsopoulos, View ORCID ProfileDamien Croteau-Chonka, View ORCID ProfileBenjamin A Raby, View ORCID ProfilePhilip L De Jager, Shamil R Sunyaev, Chris Cotsapas

doi: https://doi.org/10.1101/053165

Sung Chun

1 Division of Genetics, Brigham and Women’s Hospital, Boston MA, USA

2 Department of Medicine, Harvard School of Medicine, Boston MA, USA

3 Broad Institute of Harvard and MIT, Cambridge MA, USA

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Alexandra Casparino

4 Department of Neurology, Yale School of Medicine, New Haven CT, USA

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Nikolaos A Patsopoulos

3 Broad Institute of Harvard and MIT, Cambridge MA, USA

5 Department of Neurology, Brigham and Women’s Hospital, Boston MA, USA

6 Ann Romney Center for Neurological Diseases, Brigham and Women’s Hospital, Boston MA, USA

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ORCID record for Nikolaos A Patsopoulos

Damien Croteau-Chonka

2 Department of Medicine, Harvard School of Medicine, Boston MA, USA

7 Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston MA, USA

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ORCID record for Damien Croteau-Chonka

Benjamin A Raby

2 Department of Medicine, Harvard School of Medicine, Boston MA, USA

7 Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston MA, USA

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ORCID record for Benjamin A Raby

Philip L De Jager

2 Department of Medicine, Harvard School of Medicine, Boston MA, USA

3 Broad Institute of Harvard and MIT, Cambridge MA, USA

5 Department of Neurology, Brigham and Women’s Hospital, Boston MA, USA

6 Ann Romney Center for Neurological Diseases, Brigham and Women’s Hospital, Boston MA, USA

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ORCID record for Philip L De Jager

Shamil R Sunyaev

1 Division of Genetics, Brigham and Women’s Hospital, Boston MA, USA

2 Department of Medicine, Harvard School of Medicine, Boston MA, USA

3 Broad Institute of Harvard and MIT, Cambridge MA, USA

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For correspondence: ssunyaev@rics.bwh.harvard.edu

Chris Cotsapas

3 Broad Institute of Harvard and MIT, Cambridge MA, USA

4 Department of Neurology, Yale School of Medicine, New Haven CT, USA

8 Department of Genetics, Yale School of Medicine, New Haven CT, USA

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For correspondence: ssunyaev@rics.bwh.harvard.edu

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