Excess of Deleterious Mutations around HLA Genes Reveals Evolutionary Cost of Balancing Selection

Tobias L. Lenz; Victor Spirin; Daniel M. Jordan; Shamil R. Sunyaev

doi:10.1101/053793

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https://doi.org/10.1101/053793

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June 15, 2016.

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Tobias L. Lenz1,2,*,
Victor Spirin1 †,
Daniel M. Jordan1 ‡ and
Shamil R. Sunyaev1,3,*

¹Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
²Evolutionary Immunogenomics, Department of Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, 24306 Plön, Germany
³DProgram in Medical and Population Genetics, The Broad Institute, Cambridge, MA 02142, USA

↵*Corresponding authors: Tobias L. Lenz, Email: lenz{at}post.harvard.edu, Shamil R. Sunyaev, Email: ssunyaev{at}rics.bwh.harvard.edu

↵† Present address: Merck Research Laboratories, 470 Atlantic Avenue, Boston, MA 02210, USA
↵‡ Present address: Icahn Institute for Genomics and Multiscale Biology, Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA