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Excess of Deleterious Mutations around HLA Genes Reveals Evolutionary Cost of Balancing Selection

Tobias L. Lenz, Victor Spirin, Daniel M. Jordan, Shamil R. Sunyaev
doi: https://doi.org/10.1101/053793
Tobias L. Lenz
1Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
2Evolutionary Immunogenomics, Department of Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, 24306 Plön, Germany
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  • For correspondence: lenz@post.harvard.edu ssunyaev@rics.bwh.harvard.edu
Victor Spirin
1Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
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Daniel M. Jordan
1Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
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Shamil R. Sunyaev
1Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
3DProgram in Medical and Population Genetics, The Broad Institute, Cambridge, MA 02142, USA
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  • For correspondence: lenz@post.harvard.edu ssunyaev@rics.bwh.harvard.edu
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Posted June 15, 2016.
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Excess of Deleterious Mutations around HLA Genes Reveals Evolutionary Cost of Balancing Selection
Tobias L. Lenz, Victor Spirin, Daniel M. Jordan, Shamil R. Sunyaev
bioRxiv 053793; doi: https://doi.org/10.1101/053793
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Excess of Deleterious Mutations around HLA Genes Reveals Evolutionary Cost of Balancing Selection
Tobias L. Lenz, Victor Spirin, Daniel M. Jordan, Shamil R. Sunyaev
bioRxiv 053793; doi: https://doi.org/10.1101/053793

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