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Accounting for tumor heterogeneity using a sample-specific error model improves sensitivity and specificity in mutation calling for sequencing data

Yu Fan, Xi Liu, Hughes Daniel S. T., Jianjua Zhang, Jianhua Zhang, P. Andrew Futreal, David A. Wheeler, Wang Wenyi
doi: https://doi.org/10.1101/055467
Yu Fan
1Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, U.S.A.
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Xi Liu
2Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Alkek N1419, Houston, TX 77030-3411, U.S.A.
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Hughes Daniel S. T.
2Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Alkek N1419, Houston, TX 77030-3411, U.S.A.
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Jianjua Zhang
3Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, U.S.A.
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Jianhua Zhang
3Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, U.S.A.
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P. Andrew Futreal
3Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, U.S.A.
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David A. Wheeler
2Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Alkek N1419, Houston, TX 77030-3411, U.S.A.
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Wang Wenyi
1Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, U.S.A.
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  • For correspondence: wwang7@mdanderson.org
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Posted May 25, 2016.
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Accounting for tumor heterogeneity using a sample-specific error model improves sensitivity and specificity in mutation calling for sequencing data
Yu Fan, Xi Liu, Hughes Daniel S. T., Jianjua Zhang, Jianhua Zhang, P. Andrew Futreal, David A. Wheeler, Wang Wenyi
bioRxiv 055467; doi: https://doi.org/10.1101/055467
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Accounting for tumor heterogeneity using a sample-specific error model improves sensitivity and specificity in mutation calling for sequencing data
Yu Fan, Xi Liu, Hughes Daniel S. T., Jianjua Zhang, Jianhua Zhang, P. Andrew Futreal, David A. Wheeler, Wang Wenyi
bioRxiv 055467; doi: https://doi.org/10.1101/055467

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