Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Virtual cortical resection reveals push-pull network control preceding seizure evolution

View ORCID ProfileAnkit N. Khambhati, View ORCID ProfileKathryn A. Davis, Timothy H. Lucas, Brian Litt, Danielle S. Bassett
doi: https://doi.org/10.1101/055566
Ankit N. Khambhati
1Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA
2Penn Center for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Ankit N. Khambhati
Kathryn A. Davis
2Penn Center for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
3Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Kathryn A. Davis
Timothy H. Lucas
2Penn Center for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
4Department of Neurosurgery, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Brian Litt
1Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA
2Penn Center for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
3Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Danielle S. Bassett
1Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA
2Penn Center for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
5Department of Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Abstract

For ≈ 20 million people with drug-resistant epilepsy, recurring, spontaneous seizures have a devastating impact on daily life. The efficacy of surgical treatment for controlling seizures is hindered by a poor understanding of how some seizures spread to and synchronize surrounding tissue while others remain focal. To pinpoint network regions that regulate seizure evolution, we present a novel method to assess changes in synchronizability in response to virtually lesioning cortical areas in a validated computational network model. In human patients implanted with electrocorticographic sensors, we apply our virtual cortical resection technique to time-varying functional networks and identify control regions that synchronize or desynchronize cortical areas using an antagonistic push-pull control scheme to raise or lower synchronizability. Our results suggest that synchronizability before seizures predicts seizure evolution: in focal seizures, the strongest controllers are located outside seizure-generating areas. These methods,while applied here to epilepsy, are generalizable to other brain networks, and have wide applicability in isolating and mapping functional drivers of brain dynamics in health and disease.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted May 26, 2016.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Virtual cortical resection reveals push-pull network control preceding seizure evolution
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Virtual cortical resection reveals push-pull network control preceding seizure evolution
Ankit N. Khambhati, Kathryn A. Davis, Timothy H. Lucas, Brian Litt, Danielle S. Bassett
bioRxiv 055566; doi: https://doi.org/10.1101/055566
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
Virtual cortical resection reveals push-pull network control preceding seizure evolution
Ankit N. Khambhati, Kathryn A. Davis, Timothy H. Lucas, Brian Litt, Danielle S. Bassett
bioRxiv 055566; doi: https://doi.org/10.1101/055566

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (3514)
  • Biochemistry (7371)
  • Bioengineering (5347)
  • Bioinformatics (20328)
  • Biophysics (10048)
  • Cancer Biology (7781)
  • Cell Biology (11353)
  • Clinical Trials (138)
  • Developmental Biology (6454)
  • Ecology (9984)
  • Epidemiology (2065)
  • Evolutionary Biology (13359)
  • Genetics (9375)
  • Genomics (12614)
  • Immunology (7729)
  • Microbiology (19118)
  • Molecular Biology (7478)
  • Neuroscience (41163)
  • Paleontology (301)
  • Pathology (1235)
  • Pharmacology and Toxicology (2142)
  • Physiology (3183)
  • Plant Biology (6882)
  • Scientific Communication and Education (1276)
  • Synthetic Biology (1900)
  • Systems Biology (5328)
  • Zoology (1091)