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Distinct combinations of variant ionotropic glutamate 1 receptors mediate thermosensation and hygrosensation in Drosophila

Zachary A. Knecht, Ana F. Silbering, Lina Ni, Mason Klein, Gonzalo Budelli, Rati Bell, Liliane Abuin, Anggie J. Ferrer, Aravinthan D.T. Samuel, View ORCID ProfileRichard Benton, View ORCID ProfilePaul A. Garrity
doi: https://doi.org/10.1101/056267
Zachary A. Knecht
1National Center for Behavioral Genomics and Volen Center for Complex Systems Department of Biology, Brandeis University, Waltham, MA 02458, USA;
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Ana F. Silbering
2Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne CH-1015, Switzerland.
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Lina Ni
1National Center for Behavioral Genomics and Volen Center for Complex Systems Department of Biology, Brandeis University, Waltham, MA 02458, USA;
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Mason Klein
3Department of Physics and Center for Brain Science, Harvard University, Cambridge, MA 02138;
4Department of Physics, University of Miami, Coral Gables, FL33146, USA
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Gonzalo Budelli
1National Center for Behavioral Genomics and Volen Center for Complex Systems Department of Biology, Brandeis University, Waltham, MA 02458, USA;
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Rati Bell
2Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne CH-1015, Switzerland.
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Liliane Abuin
2Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne CH-1015, Switzerland.
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Anggie J. Ferrer
4Department of Physics, University of Miami, Coral Gables, FL33146, USA
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Aravinthan D.T. Samuel
3Department of Physics and Center for Brain Science, Harvard University, Cambridge, MA 02138;
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  • For correspondence: samuel@physics.harvard.edu Richard.Benton@unil.ch pgarrity@brandeis.edu
Richard Benton
2Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne CH-1015, Switzerland.
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  • ORCID record for Richard Benton
  • For correspondence: samuel@physics.harvard.edu Richard.Benton@unil.ch pgarrity@brandeis.edu
Paul A. Garrity
1National Center for Behavioral Genomics and Volen Center for Complex Systems Department of Biology, Brandeis University, Waltham, MA 02458, USA;
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  • ORCID record for Paul A. Garrity
  • For correspondence: samuel@physics.harvard.edu Richard.Benton@unil.ch pgarrity@brandeis.edu
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Abstract

Ionotropic Receptors (IRs) are a large subfamily of variant ionotropic glutamate receptors present across Protostomia. While these receptors are most extensively studied for their roles in chemosensory detection in insects, recent work has implicated two family members, IR21a and IR25a, in thermosensation in Drosophila. Here we characterize one of the most deeply conserved receptors, IR93a, and show that it is co-expressed and functions with IR21a and IR25a to mediate physiological and behavioral responses to cool temperatures. IR93a is also co-expressed with IR25a and a distinct receptor, IR40a, in a discrete population of sensory neurons in the sacculus, a multi-chambered pocket within the antenna. We demonstrate that this combination of receptors is important for neuronal responses to dry air and behavioral discrimination of humidity differences. Our results identify IR93a as a common component of molecularly and cellularly distinct IR pathways underlying thermosensation and hygrosensation in insects.

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Posted May 31, 2016.
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Distinct combinations of variant ionotropic glutamate 1 receptors mediate thermosensation and hygrosensation in Drosophila
Zachary A. Knecht, Ana F. Silbering, Lina Ni, Mason Klein, Gonzalo Budelli, Rati Bell, Liliane Abuin, Anggie J. Ferrer, Aravinthan D.T. Samuel, Richard Benton, Paul A. Garrity
bioRxiv 056267; doi: https://doi.org/10.1101/056267
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Distinct combinations of variant ionotropic glutamate 1 receptors mediate thermosensation and hygrosensation in Drosophila
Zachary A. Knecht, Ana F. Silbering, Lina Ni, Mason Klein, Gonzalo Budelli, Rati Bell, Liliane Abuin, Anggie J. Ferrer, Aravinthan D.T. Samuel, Richard Benton, Paul A. Garrity
bioRxiv 056267; doi: https://doi.org/10.1101/056267

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