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Transcriptional activity of TRF2 is telomere length dependent

Ananda Kishore Mukherjee, Shalu Sharma, Parashar Dhapola, Dhurjhoti Saha, Tabish Hussain, Sumitabho Deb Roy, Gunjan Purohit, Anirban Kar, Ankita Singh, Suman Sengupta, Vivek Srivastava, Manish Kumar, Sagar Sengupta, Shantanu Chowdhury
doi: https://doi.org/10.1101/056481
Ananda Kishore Mukherjee
1Proteomics and Structural Biology Unit, CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, 110025, India
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Shalu Sharma
1Proteomics and Structural Biology Unit, CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, 110025, India
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Parashar Dhapola
2G.N.R. Knowledge Centre for Genome Informatics, CSIR-Institute of Genomics and Integrative Biology Mathura Road, New Delhi, 110025, India
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Dhurjhoti Saha
1Proteomics and Structural Biology Unit, CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, 110025, India
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Tabish Hussain
1Proteomics and Structural Biology Unit, CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, 110025, India
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Sumitabho Deb Roy
1Proteomics and Structural Biology Unit, CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, 110025, India
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Gunjan Purohit
1Proteomics and Structural Biology Unit, CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, 110025, India
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Anirban Kar
1Proteomics and Structural Biology Unit, CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, 110025, India
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Ankita Singh
1Proteomics and Structural Biology Unit, CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, 110025, India
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Suman Sengupta
1Proteomics and Structural Biology Unit, CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, 110025, India
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Vivek Srivastava
1Proteomics and Structural Biology Unit, CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, 110025, India
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Manish Kumar
3Imaging facility, CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, 110025, India
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Sagar Sengupta
4National Institute of Immunology, ArunaAsaf Ali Marg, New Delhi, 110067, India
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Shantanu Chowdhury
1Proteomics and Structural Biology Unit, CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, 110025, India
2G.N.R. Knowledge Centre for Genome Informatics, CSIR-Institute of Genomics and Integrative Biology Mathura Road, New Delhi, 110025, India
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  • For correspondence: shantanuc@igib.res.in
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Abstract

TRF2 is a telomere repeat binding factor crucial for telomere maintenance and genome stability. An emerging non-conventional role of TRF2 is as a transcriptional regulator through extra-telomeric bindings. Herein we report that increase in telomere length leads to sequestration of TRF2 at the telomeres leading to reduced extra-telomeric TRF2 occupancy genome wide. Decrease in TRF2 occupancy was found on multiple gene promoters in cells with elongated telomeres, including the cell cycle regulator kinase-p21. We found that TRF2 is a transcriptional repressor of p21, and, interestingly, TRF2-mediated regulatory control of p21 is telomere length dependent.

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Posted June 03, 2016.
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Transcriptional activity of TRF2 is telomere length dependent
Ananda Kishore Mukherjee, Shalu Sharma, Parashar Dhapola, Dhurjhoti Saha, Tabish Hussain, Sumitabho Deb Roy, Gunjan Purohit, Anirban Kar, Ankita Singh, Suman Sengupta, Vivek Srivastava, Manish Kumar, Sagar Sengupta, Shantanu Chowdhury
bioRxiv 056481; doi: https://doi.org/10.1101/056481
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Transcriptional activity of TRF2 is telomere length dependent
Ananda Kishore Mukherjee, Shalu Sharma, Parashar Dhapola, Dhurjhoti Saha, Tabish Hussain, Sumitabho Deb Roy, Gunjan Purohit, Anirban Kar, Ankita Singh, Suman Sengupta, Vivek Srivastava, Manish Kumar, Sagar Sengupta, Shantanu Chowdhury
bioRxiv 056481; doi: https://doi.org/10.1101/056481

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